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MicroRNA Expression Profiles in Thyroid Tumors

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Abstract

MicroRNAs (miRNAs) constitute a recently identified class of small endogenous noncoding RNAs that act as negative regulators of the protein-coding gene expression and may impact cell differentiation, proliferation and survival, i.e., all fundamental cellular processes implicated in carcinogenesis. miRNA expression is deregulated in many types of human cancers, including thyroid cancer. The purpose of this review is to summarize the existing findings of miRNA deregulation in thyroid tumors and its potential role in thyroid cancer biology and molecular diagnostics.

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Authors and Affiliations

  1. Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Marina N. Nikiforova, Simon I. Chiosea & Yuri E. Nikiforov

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  1. Marina N. Nikiforova
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  2. Simon I. Chiosea
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  3. Yuri E. Nikiforov
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Correspondence to Marina N. Nikiforova.

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Nikiforova, M.N., Chiosea, S.I. & Nikiforov, Y.E. MicroRNA Expression Profiles in Thyroid Tumors. Endocr Pathol 20, 85–91 (2009). https://doi.org/10.1007/s12022-009-9069-z

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