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Functional Oncocytic Adrenocortical Carcinoma

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Abstract

We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically the tumor showed several features of malignancy and electron microscopy confirmed oncocytic differentiation. This case is reported as the first case of an aldosterone and cortisol-producing malignancy with an oncocytic phenotype.

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Authors and Affiliations

  1. Department of Pathology, Sunnybrook Health Science Centre, 2075 Bayview Avenue, Room E-432, Toronto, ON, M4N 3M5, Canada

    Abdullah Essa Ali & Simon J. Raphael

  2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Simon J. Raphael

Authors
  1. Abdullah Essa Ali
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  2. Simon J. Raphael
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Correspondence to Simon J. Raphael.

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Ali, A.E., Raphael, S.J. Functional Oncocytic Adrenocortical Carcinoma. Endocr Pathol 18, 187–189 (2007). https://doi.org/10.1007/s12022-007-9000-4

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  • DOI: https://doi.org/10.1007/s12022-007-9000-4

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