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The association between vitamin D3 and diabetes in both hyperuricemia and non-hyperuricemia populations

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Abstract

Background

Previous studies have shown that hyperuricemia is involved in diabetes, obesity, hypertension, chronic kidney disease, and other diseases. At the same time, studies have shown that vitamin D3 levels in the body are linked to the onset of diabetes. However, there is currently no sufficient evidence to prove whether this connection is affected by the uric acid level. Therefore, we attempted to investigate the association between vitamin D3 content and the occurrence of diabetes in populations with different uric acid levels though the data of NHANES database from 2009 to 2018.

Method

Using the NHANES database, we performed a cross-sectional analysis. The participants were chosen based on stringent inclusion and exclusion requirements. This study finally included a total number of 16,735 individuals. Multivariate logistic regression analysis was used to investigate the association between vitamin D3 and diabetes mellitus in hyperuricemia and non-hyperuricemia patients after complete adjustment, and multivariate linear regression analysis was used to illustrate the association between vitamin D3 and uric acid.

Result

The results showed that the association between vitamin D3 and diabetes was weakened in hyperuricemia patients (OR 0.95 (0.92,0.98)). An independent association was discovered between vitamin D3 and uric acid (β −0.12 (−0.16, −0.07)) in all groups of population.

Conclusions

This study shows that vitamin D3 content is associated with the incidence of diabetes in people with high level of uric acid. This study offers a fresh perspective on the elements that influence the etiology of diabetes in hyperuricemia patients.

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Author contributions

R. G. and X. W. conceived the idea; R. G. and Z. X. wrote the paper; Z. X. and R. G. collected and read the literature and revised the article; X. W. read through and corrected the paper. All authors read and approved the final paper. R. G. is the first author. Z. X. is the co-first author. X. W. is the corresponding author of this paper.

Funding

This work was Supported by Grants from National Natural Science Foundation of China (81860370), CAS “Light of West China” Program (2019) and the Open Project of State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University (2017-ZZ-15).

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Authors and Affiliations

  1. Medical College of Qinghai University, Xining, Qinghai, 810016, P. R. China

    Rongpeng Gong & Xiaoxing Wei

  2. Shaanxi University of Chinese Medicine, Xi’an, Shaanxi, 712046, P. R. China

    Zixin Xu

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  1. Rongpeng Gong
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Correspondence to Xiaoxing Wei.

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All participants provided written informed consent, and the study was approved by the NCHS Research Ethics Review Board (https://wwwn.cdc.gov/nchs/nhanes/default.aspx).

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Gong, R., Xu, Z. & Wei, X. The association between vitamin D3 and diabetes in both hyperuricemia and non-hyperuricemia populations. Endocrine 74, 90–99 (2021). https://doi.org/10.1007/s12020-021-02778-y

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