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Comparison of stress response following microwave ablation and surgical resection of benign thyroid nodules

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Abstract

Purpose

To compare the effects and safety of using microwave ablation (MWA) and surgical resection for the treatment of benign thyroid nodules (BTNs) under ultrasonic guidance and investigate the effects of this treatment on stress response.

Methods

Patients with BTNs were divided into the MWA and operation groups (72 cases each). Interleukin (IL)-6, IL-8, serum tumor necrosis factor (TNF-α), and hydrostatic visual analog scale (VAS) prior to the operation, at 6 h, 24 h, and 72 h post-operation were compared between the two groups. Operation times, hospitalization times, hospitalization expenses, and postoperative complications in the two groups were also compared. All patients underwent routine ultrasound and thyroid function testing at 3 and 6 months post-operation for assessment of nodule changes and thyroid hormone levels.

Results

Compared to the MWA group, the operation group had longer average operation times, longer hospital stays, a higher rate of neck pain after surgery, and a higher rate of fever (P < 0.05). Body temperature, as well as VAS, IL-6, IL-8, and TNF-α levels in the operation group were higher than those in the MWA group at 6 h, 24 h, and 72 h post-operation (P < 0.05). The levels of free thyroxine and free triiodothyronine in the operation group were lower than those in the MWA group (P < 0.05).

Conclusion

MWA is a safe and effective treatment for patients with BTNs. The effects of MWA are more tolerable than those of surgical resection and the physiological function of the thyroid is preserved, which has high clinical value.

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Funding

This work was supported by the Jiaozuo City Medical Research Project under grant number 2017KY040.

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Author notes

  1. These authors contributed equally: Shu-yan Liu, Wei-hong Guo

Authors and Affiliations

  1. Department of Endocrinology, The First Affiliated Hospital of Henan Polytechnic University (Jiaozuo Second People’s Hospital), 454000, Jiaozuo, China

    Shu-yan Liu, Yong-feng Li, Xiao-qing Wang, Jie Chen & Xue-hong Zhou

  2. Department of Ultrasound Medicine, The First Affiliated Hospital of Henan Polytechnic University (Jiaozuo Second People’s Hospital), 454000, Jiaozuo, China

    Wei-hong Guo, Xiao-yun Huang & Dan Xue

  3. Department of Neurology, The First Affiliated Hospital of Henan Polytechnic University (Jiaozuo Second People’s Hospital), 454000, Jiaozuo, China

    Bo Yang

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  1. Shu-yan Liu
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Correspondence to Xue-hong Zhou.

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The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the local ethics committee (No. 2016018).

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Written informed consent was obtained from all individual participants included in the study.

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Cite this article

Liu, Sy., Guo, Wh., Yang, B. et al. Comparison of stress response following microwave ablation and surgical resection of benign thyroid nodules. Endocrine 65, 138–143 (2019). https://doi.org/10.1007/s12020-019-01900-5

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  • DOI: https://doi.org/10.1007/s12020-019-01900-5

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