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Assessment of trabecular bone score (TBS) in overweight/obese men: effect of metabolic and anthropometric factors

  • Endocrine Methods and Techniques
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Abstract

The “trabecular bone score” (TBS) indirectly explores bone quality, independently of bone mineral density (BMD). We investigated the effects of anthropometric and metabolic parameters on TBS in 87 overweight/obese men. We assessed BMD and TBS by DXA, and some parameters of glucose metabolism, sex-and calciotropic hormone levels. Regression models were adjusted for either age and BMI, or age and waist circumference, or age and waist/hip ratio, also considering BMI >35 (y/n) and metabolic syndrome (MS) (y/n). Correlations between TBS and parameters studied were higher when correcting for waist circumference, although not significant in subjects with BMI >35. The analysis of covariance showed that the same model always had a higher adjusted r-square index. BMD at lumbar spine and total hip, fasting glucose, bioavailable testosterone, and sex hormone-binding globulin are the only covariates having a significant effect (p < 0.05) on the variations of TBS. The presence of MS negatively affected only the association between TBS and BMD at total hip. We did not find any significant effect of BMI >35 on TBS values or significant interaction terms between each covariate and either BMI >35 or the presence of MS. Obesity negatively affected TBS, despite unchanged BMD. Alterations of glucose homeostasis and sex hormone levels seem to influence this relationship, while calciotropic hormones have no role. The effect of waist circumference on TBS is more pronounced than that of BMI.

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Author notes

    Authors and Affiliations

    1. Department of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, “Sapienza” University of Rome, Rome, Italy

      Elisabetta Romagnoli, Carla Lubrano, Daniela Costantini, Susanna Morano, Lucio Gnessi & Andrea Lenzi

    2. Unit of Internal Medicine, ‘‘Casa Sollievo della Sofferenza’’ Hospital I.R.C.C.S., San Giovanni Rotondo, FG, Italy

      Vincenzo Carnevale

    3. Faculty of Economics, UNINT University, Rome, Italy

      Luciano Nieddu

    4. Endocrinology Unit, Department of Movement, Human and Health Sciences, University of “Foro Italico”, Rome, Italy

      Silvia Migliaccio

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    1. Elisabetta Romagnoli
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    Correspondence to Elisabetta Romagnoli.

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    Elisabetta Romagnoli, Carla Lubrano, Vincenzo Carnevale, Daniela Costantini, Luciano Nieddu, Susanna Morano, Silvia Migliaccio, Lucio Gnessi, and Andrea Lenzi declare that they have no conflict of interest.

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    All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional and/or National Research Committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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    E. Romagnoli and C. Lubrano have contributed equally to this work.

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    Romagnoli, E., Lubrano, C., Carnevale, V. et al. Assessment of trabecular bone score (TBS) in overweight/obese men: effect of metabolic and anthropometric factors. Endocrine 54, 342–347 (2016). https://doi.org/10.1007/s12020-016-0857-1

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    • DOI: https://doi.org/10.1007/s12020-016-0857-1

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