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Comparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidism

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Abstract

This study was designed to show the effect of propylthiouracil treatment on sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels on subjects with subclinical hyperthyroidism. After checking sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels of 35 patients with subclinical hyperthyroidism, each was given 50 mg tablets of propylthiouracil three times daily. After 3 months, sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels were then compared to the levels before treatment. Although high-sensitivity C-reactive protein and sCD40L levels were normal in the subclinical hyperthyroidism patients compared to the healthy controls, fetuin-A levels were statistically significantly higher (*p = 0.022). After treatment, fetuin-A levels of subclinical hyperthyroidism patients decreased statistically significantly compared to the levels before treatment (**p = 0.026). sCD40L and high-sensitivity C-reactive protein levels did not have a statistically significant difference compared to the control group and post-propylthiouracil treatment. In subclinical hyperthyroidism patients, high fetuin-A levels before propylthiouracil treatment and decreases in these levels after treatment in cases with subclinical hyperthyroidism indicated the possibility of preventing long-term cardiac complications with propylthiouracil treatment.

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Authors and Affiliations

  1. Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35380, Izmir, Turkey

    Oktay Bilgir & Tuba Topcuoglu

  2. Department of Allergy and Immunology, Celal Bayar University Medical School, Manisa, Turkey

    Ferda Bilgir

  3. Department of Endocrinology and Metabolism, Dokuz Eylul University Medical School, Izmir, Turkey

    Mehmet Calan

  4. Department of Biochemistry, Karsıyaka State Hospital, Izmir, Turkey

    Ozlem Calan

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  1. Oktay Bilgir
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  2. Ferda Bilgir
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Correspondence to Oktay Bilgir.

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Bilgir, O., Bilgir, F., Topcuoglu, T. et al. Comparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidism. Endocrine 45, 244–248 (2014). https://doi.org/10.1007/s12020-013-9993-z

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  • DOI: https://doi.org/10.1007/s12020-013-9993-z

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