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Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus

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Abstract

Omentin-1 is an adipokine implicated in diabetes, inflammation, and cardiovascular disease. However, no prospective studies have examined the impact of circulating omentin-1 levels on arterial stiffening in patients with type 2 diabetes mellitus. For the purpose of this study, we recruited 120 patients with type 2 diabetes mellitus and measured serum omentin-1, adiponectin, and high-sensitivity C-reactive protein levels as well as other cardiovascular risk factors. Arterial stiffness was assessed by brachial ankle pulse wave velocity (baPWV). An increase in the level of circulating omentin-1 over a period of 1 year was positively correlated with changes in levels of HbA1c and serum adiponectin as well as baPWV. Subjects with higher baseline serum omentin-1 levels tended to have a reduced arterial stiffness after 1 year (P for linear trend = 0.03). In the group with increased baPWV after 1 year, the magnitude of increase of circulating omentin-1 levels was significantly higher than in the group with a lower baPWV after 1 year (134.3 [16.6, 277.1] ng/mL vs. 15.9 [−67.6, 145.7] ng/mL, P < 0.01). Multiple stepwise logistic regression analysis revealed that an increase in systolic blood pressure and an increase in serum omentin-1 level were independently correlated with arterial stiffening, even after adjusting for other cardiovascular risk factors and medication history. Baseline serum omentin-1 levels can predict arterial stiffness changes occurring within a year. Furthermore, changes in serum omentin-1 levels after a year can function as independent markers of arterial stiffening in patients with type 2 diabetes mellitus.

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Acknowledgments

Dr. S. H. Baik and Dr. K. M. Choi were supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea (A102065-1011-1070100). Dr. K. M. Choi received support from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012006363). Dr. H. J. Yoo was also supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A1A1005257) and by a Korea University grant (K0933131).

Ethical standard

All participants provided written informed consent, and the Korea University Institutional Review Board, in accordance with the principles contained in the Declaration of Helsinki of the World Medical Association, approved the study protocol.

Conflict of interest

The authors have no financial or other conflicts of interest to disclose.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea

    Hye Jin Yoo, Ho Cheol Hong, Hae Yoon Choi, Sae Jeong Yang, Kyung Mook Choi & Sei Hyun Baik

  2. Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea

    Soon Young Hwang

  3. Department of Internal Medicine, College of Medicine, Ajou University, Suwon, Korea

    Kwan Woo Lee

  4. Department of Internal Medicine, College of Medicine, Inha University, Incheon, Korea

    Moon Suk Nam

  5. Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea

    Yong Soo Park

  6. Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea

    Jeong Taek Woo & Young Seol Kim

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  1. Hye Jin Yoo
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Yoo, H.J., Hwang, S.Y., Hong, H.C. et al. Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus. Endocrine 44, 680–687 (2013). https://doi.org/10.1007/s12020-013-9930-1

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