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Estrogen suppresses expression of the matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs (RECK) within the mouse uterus

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Abstract

RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the steroidal regulation of uterine RECK is lacking. To address this gap in our knowledge, we examined steroidal regulation and cellular expression of Reck mRNA and protein within the mouse uterus in vivo. Uterine Reck mRNA and protein were decreased by estrogen, while progesterone alone had no effect. The estrogen-induced down regulation could be partially blocked by progesterone. RECK was localized primarily to luminal and glandular epithelial cells and the level of expression was regulated in a similar fashion as in whole tissue by the steroids. Knock-down of endogenous RECK in human endometrial epithelial and stromal cells resulted in a significant increase in active MMP9 expression but not that of pro-MMP9 or MMP2. These studies demonstrate that RECK expression in the mouse uterus is steroidally regulated and that within endometrial epithelial and stromal cells, RECK regulates MMP9, but not MMP2 activity.

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References

  1. T.E. Curry Jr., K.G. Osteen, Endo. Rev. 24, 428–465 (2003)

    Article  CAS  Google Scholar 

  2. P.B. Cornet, C. Galant, Y. Eeckhout, P.J. Courtoy, E. Marbaix, P. Henriet, J. Clin. Endocrinol. Metab. 90, 1001–1011 (2005)

    Article  PubMed  CAS  Google Scholar 

  3. C. Galant, M. Berliere, D. Dubois, J.C. Verougstraete, A. Charles, P. Lemoine, I. Kokorine, Y. Eeckhout, P.J. Courtoy, E. Marbaix, Am. J. Pathol. 165, 83–94 (2004)

    Article  PubMed  CAS  Google Scholar 

  4. M. Hickey, J. Higham, M. Sullivan, L. Miles, I.S. Fraser, Fertil. Steril. 75, 288–296 (2001)

    Article  PubMed  CAS  Google Scholar 

  5. A.J. Vincent, N. Malakooti, J. Zhang, P.A. Rogers, B. Affandi, L.A. Salamonsen, Hum. Reprod. 14, 807–815 (1999)

    Article  PubMed  CAS  Google Scholar 

  6. H.W. Chung, J.Y. Lee, H.S. Moon, S.E. Hur, M.H. Park, Y. Wen, M.L. Polan, Fertil. Steril. 78, 787–795 (2001)

    Article  Google Scholar 

  7. T. Collette, C. Bellehumeur, R. Kats, R. Maheux, J. Mailloux, M. Villeneuve, A. Akoum, Hum. Reprod. 19, 1257–1264 (2004)

    Article  PubMed  CAS  Google Scholar 

  8. T. Collette, R. Maheux, J. Mailloux, A. Akoum, Hum. Reprod. 21, 3059–3067 (2006)

    Article  PubMed  CAS  Google Scholar 

  9. J. Szamatowicz, P. Laudanski, I. Tomaszewska, Hum. Reprod. 17, 284–288 (2002)

    Article  PubMed  CAS  Google Scholar 

  10. N. Inagaki, C. Stern, J. McBain, A. Lopata, L. Kornman, D. Wilkinson, Hum. Reprod. 18, 608–615 (2003)

    Article  PubMed  CAS  Google Scholar 

  11. N. Inagaki, L. Ung, T. Otani, D. Wilkinson, A. Lopata, Eur. J. Obstet. Gynecol. Reprod. 111, 197–203 (2003)

    Article  CAS  Google Scholar 

  12. K. Aglund, M. Rauvala, U. Puistola, T. Angstrom, T. Turpeenniemi-Hujanen, B. Zackrission, U. Stendahl, Gynecol. Oncol. 94, 699–704 (2004)

    Article  PubMed  CAS  Google Scholar 

  13. L.A. DiNezza, A. Misajon, J. Zhang, T. Jobling, M.A. Quinn, A.G. Ostor, G. Nie, A. Lopata, L.A. Salamonsen, Cancer 94, 1466–1475 (2002)

    Article  CAS  Google Scholar 

  14. N. Karahan, M. Güney, S. Baspinar, B. Oral, N. Kapucuoglu, T. Mungan, Eur. J. Gynaecol. Oncol. 28, 184–188 (2007)

    PubMed  CAS  Google Scholar 

  15. A. Lopata, F. Agresta, M.A. Quinn, C. Smith, A.G. Ostor, L.A. Salamonsen, Gynecol. Oncol. 90, 318–324 (2003)

    Article  PubMed  CAS  Google Scholar 

  16. Y. Soini, E. Alarakkola, H. Autio-Harmainen, Hum. Pathol. 28, 220–226 (1997)

    Article  PubMed  CAS  Google Scholar 

  17. J.E. Fata, A.T. Ho, K.J. Leco, R.A. Moorehead, R. Khokha, Cell. Mol. Life Sci. 57, 77–95 (2000)

    Article  PubMed  CAS  Google Scholar 

  18. D.E. Gomez, D.F. Alonso, H. Yoshiji, U.P. Thorgeirsson, Eur. J. Cell Biol. 74, 111–122 (1997)

    PubMed  CAS  Google Scholar 

  19. K.J. Leco, S.S. Apte, G.T. Taniguchi, S.P. Hawkes, R. Khokha, G.A. Schultz, D.R. Edwards, FEBS Lett. 401, 213–217 (1997)

    Article  PubMed  CAS  Google Scholar 

  20. W.B. Nothnick, Biol. Reprod. 63, 905–912 (2000)

    Article  PubMed  CAS  Google Scholar 

  21. J. Zhang, L.A. Salamonsen, Mol. Hum. Reprod. 3, 735–741 (1997)

    Article  PubMed  CAS  Google Scholar 

  22. A.L. Hampton, L.A. Salamonsen, J. Endocrinol. 141, R1–R3 (1994)

    Article  PubMed  CAS  Google Scholar 

  23. T. Higuchi, H. Kanzaki, H. Nakayama, M. Fujimoto, H. Hatayama, K. Kojima, M. Iwai, T. Mori, J. Fujita, Endocrinology 136, 4973–4981 (1995)

    Article  PubMed  CAS  Google Scholar 

  24. W. Rodgers, L.M. Matrisian, L.C. Giudice, B. Dsupin, P. Cannon, C. Svitek, F. Gorstein, K.G. Osteen, J. Clin. Invest. 94, 946–953 (1994)

    Article  PubMed  CAS  Google Scholar 

  25. R.M. Brenner, L. Rudolph, L. Matrisian, O.D. Slayden, Hum. Reprod. 11, 150–164 (1996)

    Article  PubMed  CAS  Google Scholar 

  26. L.A. Rudolph-Owen, O.D. Slayden, L.M. Matrisian, R.M. Brenner, Biol. Reprod. 59, 1349–1359 (1998)

    Article  PubMed  CAS  Google Scholar 

  27. L.A. Salamonsen, A.R. Butt, F.R. Hammond, S. Garcia, J. Zhang, J. Clin. Endocrinol. Metab. 82, 1409–1415 (1997)

    Article  PubMed  CAS  Google Scholar 

  28. C. Takahashi, Z. Sheng, T.P. Horan, H. Kitayama, M. Maki, K. Hitomi, Y. Kitaura, S. Takai, R.M. Sasahara, A. Horimoto, Y. Ikawa, B.J. Ratzkin, T. Arakawa, M. Noda, Proc. Natl. Acad. Sci. USA 95, 13221–13226 (1998)

    Article  PubMed  CAS  Google Scholar 

  29. J. Oh, R. Takahashi, S. Kondo, A. Mizoguchi, E. Adachi, R.M. Sasahara, S. Nishimura, Y. Imamura, H. Kitayama, D.B. Alexander, C. Ide, T.P. Horan, T. Arakawa, H. Yoshida, S. Nishikawa, Y. Itoh, M. Seiki, S. Itohara, C. Takahashi, M. Noda, Cell 107, 789–800 (2001)

    Article  PubMed  CAS  Google Scholar 

  30. M. Noda, C. Takahashi, Cancer Sci. 98, 1659–1665 (2007)

    Article  PubMed  CAS  Google Scholar 

  31. M. Noda, J. Oh, R. Takahashi, S. Kondo, H. Kitayama, C. Takahashi, Cancer Metastasis Rev. 22, 167–175 (2003)

    Article  PubMed  CAS  Google Scholar 

  32. R.K. Nuttall, C.L. Sampieri, C.J. Pennington, S.E. Gill, G.A. Schultz, D.R. Edwards, FEBS Lett. 563, 129–134 (2004)

    Article  PubMed  CAS  Google Scholar 

  33. S.J. Hu, G. Ren, J.L. Liu, Z.A. Zhao, Y.S. Yu, R.W. Su, X.H. Ma, H. Ni, W. Lei, Z.M. Yang, J. Biol. Chem. 283, 473–484 (2008)

    Google Scholar 

  34. E.P. Chandana, Y. Maeda, A. Ueda, H. Kiyonari, N. Oshima, M. Yamamoto, S. Kondo, J. Oh, R. Takahashi, Y. Yoshida, S. Kawashima, D.B. Alexander, H. Kitayama, C. Takahashi, Y. Tabata, T. Matsuzaki, M. Noda, BMC Dev. Biol. 10, 84 (2010)

    Article  PubMed  Google Scholar 

  35. X. Zhang, E. Hoang, W.B. Nothnick, Mol. Reprod. Dev. 76, 160–172 (2009)

    Article  PubMed  CAS  Google Scholar 

  36. W.B. Nothnick, C. Healy, X. Hong, Endocrine 37, 265–273 (2010)

    Article  PubMed  CAS  Google Scholar 

  37. D.A. Kniss, P.D. Zimmeran, C.L. Garver, R.H. Fertel, Am. J. Obstet. Gynecol. 177, 559–567 (1997)

    Article  PubMed  CAS  Google Scholar 

  38. G. Krikun, G. Mor, A. Alvero, S. Guller, F. Schatz, E. Sapi, M. Rahman, R. Caze, M. Qumsiyeh, C.J. Lockwood, Endocrinology 145, 2291–2296 (2004)

    Article  PubMed  CAS  Google Scholar 

  39. H. Kumamoto, K. Ooya, J. Oral Pathol. Med. 35, 345–351 (2006)

    Article  PubMed  CAS  Google Scholar 

  40. S. Takagi, T. Kitamura, Y. Hosaka, T. Ohsaki, D. Bosnakovsi, T. Kadosawa, M. Okumura, T. Fujinaga, J. Vet. Med. Sci. 67, 385–391 (2005)

    Article  PubMed  CAS  Google Scholar 

  41. M. Echizenya, S. Kondo, R. Takahashi, J. Oh, S. Kawashima, H. Kitayama, C. Takahashi, M. Noda, Oncogene 24, 5850–5857 (2005)

    Article  PubMed  CAS  Google Scholar 

  42. B. Welm, J. Mott, Z. Werb, Curr. Biol. 12, R209–R211 (2002)

    Article  PubMed  CAS  Google Scholar 

  43. S. Kawashima, Y. Imamura, E.P. Chandana, T. Noda, R. Takahashi, E. Adachi, C. Takahashi, M. Noda, J. Neurochem. 104, 376–385 (2008)

    PubMed  CAS  Google Scholar 

  44. T. Accorsi-Mendonca, K.B. Paiva, W.F. Zambuzi, T.M. Cestari, V.S. Lara, M.C. Sogayar, R. Taga, J.M. Granjeiro, J. Mol. Histol. 39, 201–208 (2008)

    Article  PubMed  CAS  Google Scholar 

  45. S. Kondo, C. Shukunami, Y. Morioka, N. Matsumoto, R. Takahashi, J. Oh, T. Atsumi, A. Umezawa, A. Kudo, H. Kitayama, Y. Hiraki, M. Noda, J. Cell Sci. 120, 849–857 (2007)

    Article  PubMed  CAS  Google Scholar 

  46. J. Guo, L. Zou, J. Huazhong Univ. Sci. Technol. Med. Sci. 26, 738–740 (2006)

    Article  PubMed  CAS  Google Scholar 

  47. T. Muraguchi, Y. Takegami, T. Ohtsuka, S. Kitajima, E.P.S. Chandana, A. Omura, T. Miki, R. Takahashi, N. Matsumoto, A. Ludwig, M. Noda, C. Takahashi, Nat. Neurosci. 10, 838–845 (2007)

    Article  PubMed  CAS  Google Scholar 

  48. K. Furumoto, S. Arii, A. Mori, H. Furuyama, M.J. Gorrin Rivas, T. Nakao, N. Isobe, T. Murata, C. Takahashi, M. Noda, M. Imamura, Hepatology 33, 189–195 (2001)

    Article  PubMed  CAS  Google Scholar 

  49. T. Masui, R. Doi, T. Koshiba, K. Fujimoto, S. Tsuji, S. Nakajima, M. Koizumi, E. Toyoda, S. Tulachan, D. Ito, K. Kami, T. Mori, M. Wada, M. Noda, M. Imamura, Clin. Cancer Res. 9, 1779–1784 (2003)

    PubMed  CAS  Google Scholar 

  50. P.N. Span, C.G. Sweep, P. Manders, L.V. Beex, D. Leppert, R.L. Lindberg, Cancer 97, 2710–2715 (2003)

    Article  PubMed  CAS  Google Scholar 

  51. N. Takemoto, M. Tada, Y. Hida, T. Asano, S. Cheng, T. Kuramae, J. Hamada, M. Miyamoto, S. Kondo, T. Moriuchi, Lung Cancer 58, 376–383 (2007)

    Article  PubMed  Google Scholar 

  52. C.Y. Cho, J.H. Wang, H.C. Chang, C.K. Chang, W.C. Hung, J. Cell. Physiol. 213, 65–69 (2007)

    Article  PubMed  CAS  Google Scholar 

  53. T. Takeuchi, M. Hisanaga, M. Nagao, N. Ikeda, H. Fujii, F. Koyama, T. Mukogawa, H. Matsumoto, S. Kondo, C. Takahashi, M. Noda, Y. Nakajima, Clin. Cancer Res. 10, 5572–5579 (2004)

    Article  PubMed  CAS  Google Scholar 

  54. M.F. van der Jagt, F.C. Sweep, E.T. Waas, T. Hendriks, T.J. Ruers, A.H. Merry, T. Wobbes, P.N. Span, Cancer Lett. 237, 289–297 (2006)

    Article  PubMed  Google Scholar 

  55. S.L. Li, D.L. Gao, Z.H. Zhao, Z.W. Liu, Q.M. Zhao, J.X. Yu, K.S. Chen, Y.H. Zhang, World J. Gastroenterol. 13, 6076–6081 (2007)

    Article  PubMed  Google Scholar 

  56. F. Ohl, M. Jung, C. Xu, C. Stephan, A. Rabien, M. Burkhardt, A. Nitsche, G. Kristiansen, S.A. Loening, A. Radonic, K. Jung, J. Mol. Med. 83, 1014–1024 (2005)

    Article  PubMed  CAS  Google Scholar 

  57. A. Rabien, M. Burkhardt, M. Jung, F. Fritzsche, M. Ringsdorf, H. Schicktanz, S.A. Loening, G. Kristiansen, K. Jung, Eur. Urol. 51, 1259–1266 (2007)

    Article  PubMed  CAS  Google Scholar 

  58. A.C. Riddick, C.J. Shukla, C.J. Pennington, R. Bass, R.K. Nuttall, A. Hogan, K.K. Sethia, V. Ellis, A.T. Collins, N.J. Maitland, R.Y. Ball, D.R. Edwards, Br. J. Cancer 92, 2171–2180 (2005)

    Article  PubMed  CAS  Google Scholar 

  59. Y. Li, Y. Zhang, Q. Zheng, J. Huazhong Univ. Sci. Technol. Med. Sci. 25, 552–554 (2005)

    Article  PubMed  CAS  Google Scholar 

  60. S.Y. Song, H.J. Son, E. Nam, J.C. Rhee, C. Park, Eur. J. Cancer 42, 101–108 (2006)

    Article  PubMed  CAS  Google Scholar 

  61. H.G. Kang, H.S. Kim, K.J. Kim, J.H. Oh, M.R. Lee, S.M. Seol, I. Han, J. Orthop. Res. 25, 696–702 (2007)

    Article  PubMed  CAS  Google Scholar 

  62. M. Okamura, A. Unami, M. Moto, M. Muguruma, T. Ito, M. Jin, Y. Oishi, Y. Kashida, K. Mitsumori, Cancer Lett. 245, 321–330 (2007)

    Article  PubMed  CAS  Google Scholar 

  63. S. Simizu, S. Takagi, Y. Tamura, H. Osada, Cancer Res. 65, 7455–7461 (2005)

    Article  PubMed  CAS  Google Scholar 

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The authors declare that all reported experiments were performed in accord with all applicable laws of the United States.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA

    Xuan Zhang, Caitlin Healy & Warren B. Nothnick

  2. Department of Molecular and Integrative Physiology, University of Kansas School of Medicine, Kansas City, KS, USA

    Warren B. Nothnick

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  1. Xuan Zhang
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Correspondence to Warren B. Nothnick.

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Zhang, X., Healy, C. & Nothnick, W.B. Estrogen suppresses expression of the matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs (RECK) within the mouse uterus. Endocrine 42, 97–106 (2012). https://doi.org/10.1007/s12020-012-9614-2

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