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Time course of Graves’ ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a 2-year longitudinal study

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Abstract

The findings in hyperthyroid patients with Graves’ orbitopathy (GO) of antibodies against antigens shared between the thyroid and orbit, such as the TSH-receptor (TRAb) and a novel protein G2s (G2sAb), suggested a possible common therapeutic strategy. However, the gold therapeutic standard for hyperthyrodism in these patients remains still unsettled and is mainly based on personal experience. Studies on the effect of total thyroidectomy (TT) alone or followed by radioiodine ablation (RAI) of thyroid remnants showed often conflicting results. This longitudinal study was aimed at evaluating the influence of TT alone or followed by post-surgical RAI with respect to methimazole treatment on the activity and severity of GO in patients with hyperthyroidism and GO. Sixty consecutive patients with Graves’ disease and mild/moderate GO were studied and grouped as follows: group 1, including 25 patients (16F, 9M) undergoing TT alone; group 2, including 10 patients (8F, 2M) undergoing TT followed by RAI for histological evidence of differentiated thyroid cancer; group 3, including 25 patients (18F, 7M) euthyroid under methimazole therapy, studied as controls. Clinical study of ophthalmopathy and measurements of TRAb and G2sAb were performed in all patients at start of the study (time of TT for group 1 and RAI after TT for group 2 and of the first finding of euthyroidism under methimazole treatment for group 3) and after 6, 12, 24 months. Patients of both groups 1 and 2 showed an early significant decrease and a further progressive reduction of the activity and severity of GO with a disappearance of TRAb and a decrease of G2sAb levels during the follow-up, without statistically significant differences between the two groups. Patients in group 3 showed a much later and less marked improvement of GO with persistence of TRAb and G2sAb positivity, even if with reduction of TRAb levels at 12 and 24 months. Our results suggest that in Graves’ patients with large goiter or relapse of hyperthyroidism and mild/moderate GO, TT alone could be an advisable choice to treat hyperthyroidism also improving GO with reduction of cost/benefit ratio.

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Authors and Affiliations

  1. Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Via Pansini N. 5, 80131, Naples, Italy

    Annamaria De Bellis, Elena Pane, Giuseppe Bellastella, Caterina Colella, Assunta Dello Iacovo, Vanda Amoresano Paglionico, Antonio Agostino Sinisi & Antonio Bellastella

  2. Department of Clinical and Experimental Medicine and Surgery “F. Magrassi, A. Lanzara”, Second University of Naples, Naples, Italy

    Giovanni Conzo & Antonio Bizzarro

  3. Department of Ophthalmology, Federico II University, Naples, Italy

    Gilda Cennamo

  4. Department of Medicine, The University of Sydney, Nepean Clinical School, Penrith, NSW, Australia

    Jack R. Wall

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  1. Annamaria De Bellis
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  2. Giovanni Conzo
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  3. Gilda Cennamo
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  4. Elena Pane
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  5. Giuseppe Bellastella
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  7. Assunta Dello Iacovo
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  8. Vanda Amoresano Paglionico
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  9. Antonio Agostino Sinisi
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  10. Jack R. Wall
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  11. Antonio Bizzarro
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  12. Antonio Bellastella
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Correspondence to Antonio Bellastella.

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De Bellis, A., Conzo, G., Cennamo, G. et al. Time course of Graves’ ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a 2-year longitudinal study. Endocrine 41, 320–326 (2012). https://doi.org/10.1007/s12020-011-9559-x

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  • DOI: https://doi.org/10.1007/s12020-011-9559-x

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