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Role of biological targeted therapies in gastroenteropancreatic neuroendocrine tumours

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Abstract

Approximately two-thirds of neuroendocrine tumours (NET) occur in the gastrointestinal tract and over 60% present with metastases. With greater insight into molecular pathways involved in tumour progression, opportunities are presented for the use of targeted therapies in NET. Although a wide array of targeted agents has been investigated, only a handful has emerged as forerunners from recent clinical trials. This literature review focuses on the use of anti-angiogenic monoclonal antibody bevacizumab, as well as small molecule inhibitors sunitinib and everolimus.

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Acknowledgement

NHS funding to the NIHR Biomedical Research Centre is acknowledged.

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The author has no conflict of interest to declare.

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Authors and Affiliations

  1. Gastrointestinal Cancer and Lymphoma Research Unit, The Royal Marsden NHS Foundation Trust, London, Surrey, SM2 5PT, UK

    Kein-Leong Yim

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Yim, KL. Role of biological targeted therapies in gastroenteropancreatic neuroendocrine tumours. Endocrine 40, 181–186 (2011). https://doi.org/10.1007/s12020-011-9513-y

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  • DOI: https://doi.org/10.1007/s12020-011-9513-y

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