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Epicardial adipose tissue thickness in type 1 diabetic patients

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Abstract

Insulin resistance is getting important in the course of type 1 diabetes mellitus. Visceral fat depot is associated with insulin resistance and assessment of epicardial fat thickness is a way of measuring visceral fat. The aim of the study was to measure epicardial adipose tissue (EAT) thickness and to determine its relationship with waist-hip-ratio (WHR) and estimated glucose disposal rate (eGDR) in adult type 1 diabetic patients. Thirty-six type 1 diabetic patients (aged 31 ± 8 years; Female/Male: 22/14) and 43 age, gender and BMI matched healthy controls were included. Fasting blood glucose (FBG), hemoglobin A1c, and lipid profiles were measured. Waist-hip-ratio (WHR) was calculated. Daily insulin dose/kg of patients were recorded and eGDR of all subjects was calculated. Epicardial adipose tissue (EAT) thickness was evaluated by echocardiography. EAT thickness of the type 1 diabetic patients was significantly higher than controls (3.30 ± 1.06 vs. 2.30 ± 0.34 mm, P < 0.0001). EAT thickness was correlated with age (P = 0.05; r = 0.35), WHR (P = 0.003; r = 0.67), daily insulin dose/kg (r = 0.45, P = 0.005), and eGDR (r = −0.55, P = 0.0004). Multivariate analysis revealed WHR and eGDR to be related to EAT among age, WHR, daily insulin dose/kg, eGDR, FBG, and hemoglobin A1c (r2 of the model = 0.64). Epicardial adipose tissue thickness is increased in type 1 diabetic patients compared to controls and is related to WHR and eGDR in this group of patients. This measurement may point to the presence of insulin resistance in type 1 diabetic patients.

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Authors and Affiliations

  1. Section of Endocrinology and Metabolism, Marmara University Medical School, Istanbul, Turkey

    Dilek Yazıcı, Dilek Yavuz, Oğuzhan Deyneli, Hasan Aydın, Özlem Tarcin & Sema Akalın

  2. Department of Cardiology, Marmara University Medical School, Istanbul, Turkey

    Beste Özben

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  1. Dilek Yazıcı
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Yazıcı, D., Özben, B., Yavuz, D. et al. Epicardial adipose tissue thickness in type 1 diabetic patients. Endocrine 40, 250–255 (2011). https://doi.org/10.1007/s12020-011-9478-x

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