Skip to main content

Advertisement

SpringerLink
Log in

Elevated serum γ-glutamyltransferase predicts the development of impaired glucose metabolism in middle-aged and elderly Chinese

  • Original Article
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

The aim of this article is to prospectively investigate the association of the liver enzyme γ-glutamyltransferase (GGT) with the development of diabetes and impaired glucose regulation (IGR) in a Chinese population. Seven hundred and sixty normoglycaemic subjects aged 40 years or older randomly selected from an urban community of Shanghai received a baseline investigation in May 2005. The participants were invited to receive a standard 75-g oral glucose tolerance test (OGTT) in November 2008. Incident diabetes and IGR were determined according to the 1999 WHO criteria. Serum GGT levels were significantly associated with incident diabetes or combined diabetes and IGR prospectively. After extensive adjustment, the diabetes risk was significantly increased with incrementing serum GGT quartiles (P value for trend = 0.0027). As compared with the lowest quartile of GGT, the highest quartile had an adjusted hazard ratio of 1.30 (95% CI 1.03–1.65) for developing combined diabetes and IGR. Furthermore, a high serum GGT level at baseline was independently associated with an increase in the index of homeostasis model assessment of insulin resistance (HOMA-IR) at follow-up. Serum GGT concentration, even within its normal range, is a risk marker for developing impaired glucose metabolism in middle-aged and elderly Chinese.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. G. Marchesini, M. Brizi, G. Bianchi, S. Tomassetti, E. Bugianesi, M. Lenzi, A.J. McCullough, S. Natale, G. Forlani, N. Melchionda, Diabetes 50, 1844–1850 (2001)

    Article  PubMed  CAS  Google Scholar 

  2. J.M. Clark, F.L. Brancati, A.M. Diehl, Am. J. Gastroenterol. 98, 960–967 (2003)

    Article  PubMed  CAS  Google Scholar 

  3. R. Teschke, A. Brand, G. Strohmeyer, Biochem. Biophys. Res. Commun. 75, 718–724 (1977)

    Article  PubMed  CAS  Google Scholar 

  4. D.J. Kim, J.H. Noh, N.H. Cho, B.W. Lee, Y.H. Choi, J.H. Jung, Y.K. Min, M.S. Lee, M.K. Lee, K.W. Kim, Diabet. Med. 22, 1134–1140 (2005)

    Article  PubMed  CAS  Google Scholar 

  5. A. Fraser, S. Ebrahim, G.D. Smith, D.A. Lawlor, Hepatology 46, 158–165 (2007)

    Article  PubMed  CAS  Google Scholar 

  6. I.J. Perry, S.G. Wannamethee, A.G. Shaper, Diabetes Care 21, 732–737 (1998)

    Article  PubMed  CAS  Google Scholar 

  7. Y. Doi, M. Kubo, K. Yonemoto, T. Ninomiya, M. Iwase, Y. Tanizaki, K. Shikata, M. Iida, Y. Kiyohara, Obesity Res. 15, 1841–1850 (2007)

    Article  CAS  Google Scholar 

  8. E.S. Ford, M.B. Schulze, M.M. Bergmann, C. Thamer, H.G. Joost, H. Boeing, Diabetes Care 31, 1138–1143 (2008)

    Article  PubMed  Google Scholar 

  9. A. Fraser, R. Harris, N. Sattar, S. Ebrahim, G. Davey Smith, D.A. Lawlor, Diabetes Care 32, 741–750 (2009)

    Article  PubMed  CAS  Google Scholar 

  10. M. Nannipieri, C. Gonzales, S. Baldi, R. Posadas, K. Williams, S.M. Haffner, M.P. Stern, E. Ferrannini, Diabetes Care 28, 1757–1762 (2005)

    Article  PubMed  CAS  Google Scholar 

  11. P. André, B. Balkau, S. Vol, M.A. Charles, E. Eschwège, DESIR Study Group, Diabetes Care 30, 2355–2361 (2007)

    Article  PubMed  Google Scholar 

  12. D.S. Lee, J.C. Evans, S.J. Robins, P.W. Wilson, I. Albano, C.S. Fox, T.J. Wang, E.J. Benjamin, R.B. D’Agostino, R.S. Vasan, Arterioscler. Thromb. Vasc. Biol. 27, 127–133 (2007)

    Article  PubMed  CAS  Google Scholar 

  13. J. Xiang, X.Y. Li, M. Xu, J. Hong, Y. Huang, J.R. Tan, X. Lu, M. Dai, B. Yu, G. Ning, J. Clin. Endocrinol. Metab. 93, 4107–4112 (2008)

    Article  PubMed  CAS  Google Scholar 

  14. M. Xu, X.Y. Li, J.G. Wang, X.J. Wang, Y. Huang, Q. Cheng, H.E. Huang, R. Li, J. Xiang, J.R. Tan, M. Dai, G. Ning, Diabetologia 52, 1511–1519 (2009)

    Article  PubMed  CAS  Google Scholar 

  15. M. Rosell, U. De Faire, M.L. Hellénius, Eur. J. Clin. Nutr. 57, 227–234 (2003)

    Article  PubMed  CAS  Google Scholar 

  16. M.A. Abdul-Ghani, R.A. DeFronzo, Curr. Diab. Rep. 9, 193–199 (2009)

    Article  PubMed  CAS  Google Scholar 

  17. T.P. Whitehead, D. Robinson, S.L. Allaway, Ann. Clin. Biochem. 33, 530–535 (1996)

    PubMed  Google Scholar 

  18. T.M. Wallace, J.C. Levy, D.R. Matthews, Diabetes Care 27, 1487–1495 (2004)

    Article  PubMed  Google Scholar 

  19. M. Emdin, C. Passino, C. Michelassi, F. Titta, A. L’abbate, L. Donato, A. Pompella, A. Paolicchi, Eur. Heart J. 22, 1802–1807 (2001)

    Article  PubMed  CAS  Google Scholar 

  20. M. Emdin, C. Passino, L. Donato, A. Paolicchi, A. Pompella, Stroke 33, 1163–1164 (2002)

    Article  PubMed  Google Scholar 

  21. E. Ruttmann, L.J. Brant, H. Concin, G. Diem, K. Rapp, H. Ulmer, Circulation 112, 2130–2137 (2005)

    Article  PubMed  CAS  Google Scholar 

  22. H.J. Forman, R.M. Liu, L. Tian, Lung Biol. Health Dis. 105, 99–121 (1997)

    CAS  Google Scholar 

  23. A. Paolicchi, M. Emdin, E. Ghliozeni, E. Ciancia, C. Passino, G. Popoff, A. Pompella, Circulation 109, 1440 (2004)

    Article  PubMed  Google Scholar 

  24. D.H. Lee, M.D. Gross, D.R. Jacobs Jr., Clin. Chem. 50, 582–588 (2004)

    Article  PubMed  CAS  Google Scholar 

  25. D.H. Lee, L.M. Steffen, D.R. Jacobs, Am. J. Clin. Nutr. 79, 600–605 (2004)

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The present study would not have been possible without the participation of the participants. This research was supported by the grants from the National Key New Drug Creation and Manufacturing Program (No. 2008ZX09312/019), the National Key Technologies Research and Development Program (No. 2008BAI52B03), and Shanghai Committee for Science and Technology (No. 09XD1403400).

Conflicts of interest

The authors have no potential conflicts of interest to be disclosed.

Author information

Authors and Affiliations

  1. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, The State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China

    Yu Xu, Min Xu, Yun Huang, Tiange Wang, Mian Li, Yaohua Wu, Aiyun Song, Xiaoying Li, Yufang Bi & Guang Ning

  2. The Division of Endocrine and Metabolic Diseases, E-Institute of Shanghai Universities, Shanghai, 200025, China

    Xiaoying Li & Guang Ning

  3. Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Rui-Jin 2nd Road, Shanghai, 200025, China

    Yufang Bi

Authors
  1. Yu Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Min Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yun Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tiange Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mian Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yaohua Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Aiyun Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Xiaoying Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yufang Bi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Guang Ning
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yufang Bi.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 12 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Xu, Y., Xu, M., Huang, Y. et al. Elevated serum γ-glutamyltransferase predicts the development of impaired glucose metabolism in middle-aged and elderly Chinese. Endocrine 40, 265–272 (2011). https://doi.org/10.1007/s12020-011-9468-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-011-9468-z

Keywords

Search

Navigation