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Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice

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Abstract

Urocortin 3 (Ucn3) is recognized as a member of the corticotropin-releasing factor (CRF) family, which plays an important role in regulating food intake. We investigated the effects of centrally administered Ucn3 on food intake and gastric emptying in mice. Intracerebroventricular (ICV) administration of Ucn3 (0.1–1 nmol per mouse) decreased food intake in a dose-dependent manner. The inhibitory effect of Ucn3 on food intake was less potent than that of centrally administered CRF and Urocortin 1. ICV administration of Ucn3 (0.1–1 nmol per mouse) decreased the gastric emptying rate in a dose-dependent manner. Ucn3 decreased food intake in high-fat diet-fed obese mice as well as in lean mice. These results indicated that Ucn3 influences feeding behavior and gut motility, and may be a promising therapeutic target in the treatment of eating and functional gastrointestinal disorders.

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Authors and Affiliations

  1. Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan

    Miharu Ushikai, Akihiro Asakawa, Takeo Sakoguchi & Akio Inui

  2. Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Chie Tanaka

Authors
  1. Miharu Ushikai
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  2. Akihiro Asakawa
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  3. Takeo Sakoguchi
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  4. Chie Tanaka
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  5. Akio Inui
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Correspondence to Akihiro Asakawa.

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Ushikai, M., Asakawa, A., Sakoguchi, T. et al. Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice. Endocr 39, 113–117 (2011). https://doi.org/10.1007/s12020-010-9420-7

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  • DOI: https://doi.org/10.1007/s12020-010-9420-7

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