Skip to main content

Advertisement

Log in

Allergic reactions to human insulin: a review of current knowledge and treatment options

  • Review
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Although the incidence of insulin allergy decreased after the introduction of recombinant human insulin preparations, it is still a major problem which may be life-threatening in some cases. In this article, we attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. L. Fernandez, S. Duque, C. Montalban, B. Bartolome, Allergy 58, 1317 (2003)

    Article  PubMed  CAS  Google Scholar 

  2. C. Blanco, R. Castillo, J. Quiralte, J. Delgado, I. Garcia, P. de Pablos, T. Carrillo, Allergy 51, 421–424 (1996)

    PubMed  CAS  Google Scholar 

  3. L. Heinzerling, K. Raile, H. Rochlitz, T. Zuberbier, M. Worm, Allergy 63, 148–155 (2008)

    Article  PubMed  CAS  Google Scholar 

  4. T. Mandrup-Poulsen, J. Molvig, J. Pildal, A.A. Rasmussen, L. Andersen, B.G. Skov, J. Petersen, Diabetes Care 25, 242–243 (2002)

    Article  PubMed  Google Scholar 

  5. R. Wessbecher, M. Kiehn, E. Stoffel, I. Moll, Allergy 56, 919–920 (2001)

    Article  PubMed  CAS  Google Scholar 

  6. R.P. Radermecker, A.J. Scheen, Diabetes Metab. Res. Rev. 23, 348–355 (2007)

    Article  PubMed  CAS  Google Scholar 

  7. G. Schernthaner, Diabetes Care 16(Suppl 3), 155–165 (1993)

    PubMed  Google Scholar 

  8. P. Darmon, V. Castera, M.C. Koeppel, C. Petitjean, A. Dutour, Diabetes Care 28, 2980 (2005)

    Article  PubMed  Google Scholar 

  9. M.E. Silva, M.J. Mendes, M.J. Ursich, D.M. Rocha, A.H. Brito, R.T. Fukui, G.B. Ruggeri, M. Nery, B.L. Wajchenberg, Diabetes Res. Clin. Pract. 36, 67–70 (1997)

    Article  PubMed  CAS  Google Scholar 

  10. R.D. de Shazo, T.M. Boehm, D. Kumar, J.A. Galloway, H.F. Dvorak, J. Allergy Clin. Immunol. 69, 229–237 (1982)

    Article  Google Scholar 

  11. H.G. Velcovsky, K.F. Federlin, Diabetes Care 5(Suppl 2), 126–128 (1982)

    PubMed  Google Scholar 

  12. U. Bodtger, M. Wittrup, Diabet. Med. 22, 102–106 (2005)

    Article  PubMed  CAS  Google Scholar 

  13. R.S. Gruchalla, Curr. Opin. Allergy Clin. Immunol. 2, 295–296 (2002)

    Article  PubMed  Google Scholar 

  14. R. Patterson, M. Roberts, L.C. Grammer, Ann. Allergy 64, 459–462 (1990)

    PubMed  CAS  Google Scholar 

  15. M. Katahira, I. Hara, T. Nishizaki, Diabet. Med. 22, 1455–1457 (2005)

    Article  PubMed  CAS  Google Scholar 

  16. M.E. Bollinger, R.G. Hamilton, R.A. Wood, J. Allergy Clin. Immunol. 104, 462–465 (1999)

    Article  PubMed  CAS  Google Scholar 

  17. D.F. Child, S.G. Johansson, Allergy 39, 630–633 (1984)

    Article  PubMed  CAS  Google Scholar 

  18. L.A. Witters, J.L. Ohman, G.C. Weir, L.W. Raymond, F.C. Lowell, Am. J. Med. 63, 703–709 (1977)

    Article  PubMed  CAS  Google Scholar 

  19. A.Y. Lee, W.Y. Chey, J. Choi, J.S. Jeon, Acta Derm. Venereol. 82, 114–117 (2002)

    Article  PubMed  Google Scholar 

  20. L. Grammer, Clin. Rev. Allergy 4, 189–200 (1986)

    PubMed  CAS  Google Scholar 

  21. A. Adachi, A. Fukunaga, T. Horikawa, Int. J. Dermatol. 43, 597–599 (2004)

    Article  PubMed  Google Scholar 

  22. H. Nishi, S. Nishimura, M. Higashiura, N. Ikeya, H. Ohta, T. Tsuji, M. Nishimura, S. Ohnishi, H. Higashi, J. Immunol. Methods 240, 39–46 (2000)

    Article  PubMed  CAS  Google Scholar 

  23. M. Maislos, P.M. Mead, D.H. Gaynor, D.C. Robbins, J. Clin. Invest. 77, 717–723 (1986)

    Article  PubMed  CAS  Google Scholar 

  24. V. Castera, A. Dutour-Meyer, M. Koeppel, C. Petitjean, P. Darmon, Diabetes Metab. 31, 391–400 (2005)

    Article  PubMed  CAS  Google Scholar 

  25. J.A. Loeb, K.C. Herold, K.P. Barton, L.E. Robinson, J.B. Jaspan, Diabetes Care 12, 421–423 (1989)

    Article  PubMed  CAS  Google Scholar 

  26. W. Grant, R.D. de Shazo, J. Frentz, Diabetes Care 9, 318–319 (1986)

    PubMed  CAS  Google Scholar 

  27. H. Yokoyama, S. Fukumoto, H. Koyama, M. Emoto, Y. Kitagawa, Y. Nishizawa, Diabetes Res. Clin. Pract. 61, 161–166 (2003)

    Article  PubMed  CAS  Google Scholar 

  28. H.H. Chng, K.P. Leong, K.C. Loh, Allergy 50, 984–987 (1995)

    Article  PubMed  CAS  Google Scholar 

  29. V. Matheu, E. Perez, M. Hernandez, E. Diaz, R. Darias, A. Gonzalez, J.C. Garcia, I. Sanchez, L. Feliciano, A. Caballero et al., Clin. Mol. Allergy 3, 16 (2005)

    Article  PubMed  Google Scholar 

  30. C. Frigerio, M. Aubry, F. Gomez, L. Graf, E. Dayer, N. de Kalbermatten, R.C. Gaillard, F. Spertini, Allergy 52, 238–239 (1997)

    Article  PubMed  CAS  Google Scholar 

  31. M. Asai, M. Yoshida, Y. Miura, N. Engl. J. Med. 354, 307–309 (2006)

    Article  PubMed  CAS  Google Scholar 

  32. K.A. Neville, C.F. Verge, B.K. Wainstein, H.J. Woodhead, J.B. Ziegler, J.L. Walker, Pediatr. Diabetes 9, 420–422 (2008)

    Article  PubMed  CAS  Google Scholar 

  33. N.S. Fineberg, S.E. Fineberg, J.H. Anderson, M.A. Birkett, R.G. Gibson, S. Hufferd, Diabetes 45, 1750–1754 (1996)

    Article  PubMed  CAS  Google Scholar 

  34. A. Lindholm, L.B. Jensen, P.D. Home, P. Raskin, B.O. Boehm, J. Rastam, Diabetes Care 25, 876–882 (2002)

    Article  PubMed  CAS  Google Scholar 

  35. X. JiXiong, L. Jianying, C. Yulan, C. Huixian, Diabetes Care 27, 2084–2085 (2004)

    Article  PubMed  Google Scholar 

  36. R. Barranco, T. Herrero, P. Tornero, M. Barrio, C. Frutos, A. Rodriguez, V. Malvetti, M. Luisa Baeza, Allergy 58, 536–537 (2003)

    Article  PubMed  CAS  Google Scholar 

  37. S. Mizuhashi, K. Nakamura, Y. Mori, M. Noda, K. Nakanishi, Diabetes Care 29, 1711–1712 (2006)

    Article  PubMed  Google Scholar 

  38. R.E. Ratner, T.M. Phillips, M. Steiner, Diabetes 39, 728–733 (1990)

    Article  PubMed  CAS  Google Scholar 

  39. I.B. Hirsch, N. Engl. J. Med. 352, 174–183 (2005)

    Article  PubMed  CAS  Google Scholar 

  40. D. Kumar, Diabetes Care 20, 1357–1359 (1997)

    Article  PubMed  CAS  Google Scholar 

  41. M.R. Abraham, B.A. al-Sharafi, G.A. Saavedra, R. Khardori, Diabetes Care 22, 1916–1917 (1999)

    Article  PubMed  CAS  Google Scholar 

  42. M. Lluch-Bernal, M. Fernandez, J.L. Herrera-Pombo, J. Sastre, Allergy 54, 186–187 (1999)

    Article  PubMed  CAS  Google Scholar 

  43. P. Panczel, N. Hosszufalusi, M.M. Horvath, A. Horvath, Allergy 55, 409–410 (2000)

    Article  PubMed  CAS  Google Scholar 

  44. S. Ghosh, V. McCann, L. Bartle, A. Collier, I. Malik, Diabet. Med. 24, 1307 (2007)

    Article  PubMed  CAS  Google Scholar 

  45. I.R. Blumer, Diabetes Care 29, 946 (2006)

    Article  PubMed  Google Scholar 

  46. M.A. Mollar-Puchades, I.L. Villanueva, Diabetes Res. Clin. Pract. 83, e21–e22 (2009)

    Article  PubMed  CAS  Google Scholar 

  47. H. Takata, Y. Kumon, F. Osaki, C. Kumagai, K. Arii, Y. Ikeda, T. Suehiro, K. Hashimoto, Diabetes Care 26, 253–254 (2003)

    Article  PubMed  Google Scholar 

  48. H. Moriyama, M. Nagata, K. Fujihira, K. Yamada, S.A. Chowdhury, S. Chakrabarty, Z. Jin, H. Yasuda, H. Ueda, K. Yokono, Diabetes Care 24, 411–412 (2001)

    Article  PubMed  CAS  Google Scholar 

  49. C. Kara, A.O. Kutlu, O. Evliyaoglu, H. Bilgili, N. Yildirim, Diabetes Care 28, 983–984 (2005)

    Article  PubMed  Google Scholar 

  50. C. Pfohler, C.S. Muller, D.O. Hasselmann, W. Tilgen, J. Med. Case Reports 2, 283 (2008)

    Article  PubMed  Google Scholar 

  51. M. Hara, Y. Izumida, N. Sato, K. Ohashi, J.I. Osuga, K. Tobe, K. Tsukamoto, T. Kadowaki, Diabetes Res. Clin. Pract. 84, 48–49 (2009)

    Google Scholar 

  52. K.N. Durand-Gonzalez, N. Guillausseau, C. Pecquet, J.P. Gayno, Diabetes Care 26, 2216 (2003)

    Article  PubMed  Google Scholar 

  53. V. Moyes, R. Driver, A. Croom, R. Mirakian, T.A. Chowdhury, Diabet. Med. 23, 204–206 (2006)

    Article  PubMed  CAS  Google Scholar 

  54. I. Blumer, Diabet. Med. 25, 1008 (2008)

    Article  PubMed  Google Scholar 

  55. A. Sola-Gazagnes, C. Pecquet, J. M’Bemba, E. Larger, G. Slama, Lancet 369, 637–638 (2007)

    Article  PubMed  CAS  Google Scholar 

  56. E. Perez, R. Gonzalez, J. Martinez, J. Iglesias, V. Matheu, Ann. Allergy Asthma Immunol. 102, 174–175 (2009)

    Article  PubMed  Google Scholar 

  57. S.S. Eapen, E.L. Connor, J.E. Gern, Ann. Allergy Asthma Immunol. 85, 395–397 (2000)

    Article  PubMed  CAS  Google Scholar 

  58. E.J. Pratt, P. Miles, D. Kerr, Diabet. Med. 18, 515–516 (2001)

    Article  PubMed  CAS  Google Scholar 

  59. S. Naf, E. Esmatjes, M. Recasens, A. Valero, I. Halperin, I. Levy, R. Gomis, Diabetes Care 25, 634–635 (2002)

    Article  PubMed  Google Scholar 

  60. A. Sola-Gazagnes, C. Pecquet, R. Radermecker, L. Pietri, F. Elgrably, G. Slama, J.L. Selam, Diabetes Care 26, 2961–2962 (2003)

    Article  PubMed  Google Scholar 

  61. B.A. Geldof, A.P. Oranje, T. van Joost, Contact Dermatitis 20, 384–385 (1989)

    Article  PubMed  CAS  Google Scholar 

  62. J. Beltrand, S. Guilmin-Crepon, M. Castanet, M. Peuchmaur, P. Czernichow, C. Levy-Marchal, Horm. Res. 65, 253–260 (2006)

    Article  PubMed  CAS  Google Scholar 

  63. K.N. Durand-Gonzalez, N. Guillausseau, M.L. Anciaux, V. Hentschel, J.P. Gayno, Diabetes Metab. 29, 432–434 (2003)

    Article  PubMed  CAS  Google Scholar 

  64. T. Richardson, D. Kerr, Am. J. Clin. Dermatol. 4, 661–667 (2003)

    Article  PubMed  Google Scholar 

  65. J. Leonet, J. Malaise, E. Goffin, C. Lefebvre, D. Tennstedt, B. Vandeleene, M. Buysschaert, J.P. Squifflet, Transpl. Int. 19, 474–477 (2006)

    Article  PubMed  Google Scholar 

  66. P.F. Yong, R. Malik, S. Arif, M. Peakman, S. Amiel, M.A. Ibrahim, A.N. Gough, Engl. J. Med. 360, 1045–1047 (2009)

    Article  CAS  Google Scholar 

  67. K.A. Page, S. Dejardin, C.R. Kahn, R.N. Kulkarni, K.C. Herold, S.E. Inzucchi, Nat. Clin. Pract. Endocrinol. Metab. 3, 835–840 (2007)

    Article  PubMed  Google Scholar 

  68. E. Arioglu, A. Andewelt, C. Diabo, M. Bell, S.I. Taylor, P. Gorden, Medicine (Baltimore) 81, 87–100 (2002)

    Article  CAS  Google Scholar 

  69. J.W. Eriksson, T. Bremell, B. Eliasson, J. Fowelin, L. Fredriksson, Z.W. Yu, Diabetes Care 21, 1217–1220 (1998)

    Article  PubMed  CAS  Google Scholar 

  70. K. Kawanishi, K. Kawamura, Y. Nishina, A. Goto, S.J. Okada, Clin. Endocrinol. Metab. 44, 15–21 (1977)

    Article  CAS  Google Scholar 

  71. A.P. Coll, S. Thomas, G.J. Mufti, N. Engl. J. Med. 350, 310–311 (2004)

    Article  PubMed  CAS  Google Scholar 

  72. A. Gehi, A. Webb, M. Nolte, J. Davis Jr., Arthritis Rheum. 48, 1067–1070 (2003)

    Article  PubMed  Google Scholar 

  73. Y. Kajimoto, R. Kawamori, Y. Fujitani, M. Kishimoto, M. Kubota, Y. Yamasaki, T. Morishima, T. Kamada, Endocr. J. 42, 101–105 (1995)

    Article  PubMed  CAS  Google Scholar 

  74. B.C. McLeod, Best Pract. Res. Clin. Haematol. 19, 157–167 (2006)

    Article  PubMed  CAS  Google Scholar 

  75. R. Koyama, K. Nakanishi, M. Kato, S. Yamashita, H. Kuwahara, H. Katori, Am. J. Med. Sci. 329, 259–264 (2005)

    Article  PubMed  Google Scholar 

  76. F. Bayraktar, B. Akinci, F. Demirkan, S. Yener, S. Yesil, C. Kirmaz, A. Comlekci, Diabet. Med. 26, 659–660 (2009)

    Article  PubMed  CAS  Google Scholar 

  77. H.K. Oh, R. Provenzano, J. Hendrix, M.W. el-Nachef, Clin. Transplant. 12, 593–595 (1998)

    PubMed  CAS  Google Scholar 

  78. J. Malaise, J. Leonet, E. Goffin, C. Lefebvre, D. Tennstedt, B. Vandeleene, M. Buysschaert, J.P. Squifflet, Transplant. Proc. 37, 2839 (2005)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Baris Akinci.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Akinci, B., Yener, S., Bayraktar, F. et al. Allergic reactions to human insulin: a review of current knowledge and treatment options. Endocr 37, 33–39 (2010). https://doi.org/10.1007/s12020-009-9256-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-009-9256-1

Keywords

Navigation