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Aspirin prevents diabetic oxidative changes in rat lacrimal gland structure and function

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Abstract

The aim of this study is to evaluate whether aspirin reduces Diabetis Mellitus (DM) oxidative damage in the lacrimal gland (LG), and ocular surface (OS). Ten weeks after streptozotocin induced DM and aspirin treatment, LG and OS of rats were compared for tear secretion, hidtology, peroxidase activity, and expression of uncoupling proteins (UCPs). DM reduction of tear secretion was prevented by aspirin (P < 0.01). Alterations of LG morphology and increased numbers of lipofucsin-like inclusions were observed in diabetic but not in aspirin-treated diabetic rats. Peroxidase activity levels were higher and UCP-2 was reduced in DM LG but not in aspirin treated (P = 0.0025 and P < 0.05, respectively). The findings prevented by aspirin indicate a direct inhibitory effect on oxidative pathways in LG and their inflammatory consequences, preserving the LG structure and function against hyperglycemia and/or insulin deficiency damage.

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Acknowledgments

The authors thank Mrs. Vani Maria Alves Correa for technical assistance with this work and Prof. Peter Reinach and Mrs Electra Green for reviewing the manuscript. The authors also thank the financial support of: Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior. Conselho (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas de Ribeirão Preto da Faculdade de Medicina de Ribeirão Preto (FAEPA) e Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP).

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Authors and Affiliations

  1. Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço e, FMRP, Universidade de São Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, SP, Brazil

    Angélica Gobbi Jorge, Carolina Maria Módulo, Ana Carolina Dias, Alexandre Martins Braz, Rubens Bertazolli Filho, Alceu A. Jordão Jr, Jayter Silva de Paula & Eduardo Melani Rocha

  2. Departamento de Clínica Médica da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil

    Angélica Gobbi Jorge, Carolina Maria Módulo, Ana Carolina Dias, Alexandre Martins Braz, Rubens Bertazolli Filho, Alceu A. Jordão Jr, Jayter Silva de Paula & Eduardo Melani Rocha

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  1. Angélica Gobbi Jorge
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  2. Carolina Maria Módulo
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Jorge, A.G., Módulo, C.M., Dias, A.C. et al. Aspirin prevents diabetic oxidative changes in rat lacrimal gland structure and function. Endocr 35, 189–197 (2009). https://doi.org/10.1007/s12020-009-9151-9

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