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Wolfram Syndrome: Case Report and Review of the Literature

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Comprehensive Therapy

Wolfram syndrome (WFS) is a rare diffuse neurodegenerative disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and a wide variety of central nervous system abnormalities. Insulin-dependent diabetes mellitus with optic nerve atrophy is a sufficient criterion for the diagnosis. WFS is a devastating disease for the patients and their families. This study emphasizes the need for careful evaluation of cases having insulin-dependent diabetes mellitus and optic atrophy.

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Authors and Affiliations

  1. Department of Ophthalmology, Diyarbakır State Hospital, Diyarbakır, Turkey

    Şeyhmus Ari

  2. Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey

    Uğur Keklíkçí, İhsan Çaça & Kaan Ünlü

  3. Department of Internal Medicine, Dicle University Faculty of Medicine, Diyarbakır, Turkey

    Hasan Kayabaşi

  4. Diyarbakır Devlet Hastanesi, 21280, Diyarbakır, Turkey

    Şeyhmus Ari

Authors
  1. Şeyhmus Ari
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  2. Uğur Keklíkçí
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  3. İhsan Çaça
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  4. Kaan Ünlü
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  5. Hasan Kayabaşi
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Corresponding author

Correspondence to Şeyhmus Ari.

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The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

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Ari, Ş., Keklíkçí, U., Çaça, İ. et al. Wolfram Syndrome: Case Report and Review of the Literature. Compr Ther 33, 18–20 (2007). https://doi.org/10.1007/s12019-007-0007-z

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  • DOI: https://doi.org/10.1007/s12019-007-0007-z

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