Abstract
The clathrin assembly protein, CALM, promotes the assembly of clathrin-coated vesicles. In a previous study, we showed that CALM controls the level of the synaptic vesicle protein VAMP2 at the plasma membrane by regulating VAMP2 endocytosis. Here, we provide evidence that CALM also influences the cell surface level of the AMPA receptor subunit GluR2. Although mechanistic details as well as the physiological relevance of CALM and GluR2 in the neuron have yet to be established, CALM-mediated trafficking could function as a component of a dedicated system for controlling postsynaptic abundance of GluR2.
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This work was supported by the Intramural Research Program of the National Institute on Aging of the NIH.
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Harel A, Wu F, Mattson MP, Morris CM, Yao PJ. Evidence for CALM in directing VAMP2 trafficking. Traffic 2008; 9:417-429.
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Harel, A., Mattson, M.P. & Yao, P.J. CALM, A Clathrin Assembly Protein, Influences Cell Surface GluR2 Abundance. Neuromol Med 13, 88–90 (2011). https://doi.org/10.1007/s12017-010-8142-6
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DOI: https://doi.org/10.1007/s12017-010-8142-6