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Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

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An Erratum to this article was published on 04 September 2009

Abstract

The purpose of this review is to highlight recent advances in the neuropathology associated with Mn exposures. We commence with a discussion on occupational manganism and clinical aspects of the disorder. This is followed by novel considerations on Mn transport (see also chapter by Yokel, this volume), advancing new hypotheses on the involvement of several transporters in Mn entry into the brain. This is followed by a brief description of the effects of Mn on neurotransmitter systems that are putative modulators of dopamine (DA) biology (the primary target of Mn neurotoxicity), as well as its effects on mitochondrial dysfunction and disruption of cellular energy metabolism. Next, we discuss inflammatory activation of glia in neuronal injury and how disruption of synaptic transmission and glial-neuronal communication may serve as underlying mechanisms of Mn-induced neurodegeneration commensurate with the cross-talk between glia and neurons. We conclude with a discussion on therapeutic aspects of Mn exposure. Emphasis is directed at treatment modalities and the utility of chelators in attenuating the neurodegenerative sequelae of exposure to Mn. For additional reading on several topics inherent to this review as well as others, the reader may wish to consult Aschner and Dorman (Toxicological Review 25:147–154, 2007) and Bowman et al. (Metals and neurodegeneration, 2009).

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Acknowledgments

The authors gratefully acknowledge partial support by grants from NIEHS 10563 and DoD W81XWH-05-1-0239 (MA), NINDS 061309-01 (KME) and NIEHS 012941 (RT).

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Authors and Affiliations

  1. Departments of Pediatrics and Pharmacology and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, 2215-B Garland Avenue, 11425 MRB IV, Nashville, TN, 37232-0414, USA

    Michael Aschner

  2. Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC, USA

    Keith M. Erikson

  3. Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR, USA

    Elena Herrero Hernández

  4. Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA

    Ronald Tjalkens

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  1. Michael Aschner
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  2. Keith M. Erikson
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  4. Ronald Tjalkens
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Correspondence to Michael Aschner.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s12017-009-8084-z

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Aschner, M., Erikson, K.M., Hernández, E.H. et al. Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology. Neuromol Med 11, 252–266 (2009). https://doi.org/10.1007/s12017-009-8083-0

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