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MicroRNAs in Adult and Embryonic Neurogenesis

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Abstract

Neurogenesis is defined as a process that includes the proliferation of neural stem/progenitor cells (NPCs) and the differentiation of these cells into new neurons that integrate into the existing neuronal circuitry. MicroRNAs (miRNAs) are a recently discovered class of small non-protein coding RNA molecules implicated in a wide range of diverse gene regulatory mechanisms. More and more data demonstrate that numerous miRNAs are expressed in a spatially and temporally controlled manners in the nervous system, which suggests that miRNAs have important roles in the gene regulatory networks involved in both brain development and adult neural plasticity. This review summarizes the roles of miRNAs-mediated gene regulation in the nervous system with focus on neurogenesis in both embryonic and adult brains.

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Acknowledgments

We would like to thank Dr. Weixiang Guo for helping with the figures and Dr. Zhaoqian Teng for helping with the references. Images in this manuscript were generated in the University of New Mexico Cancer Center Fluorescence Microscopy Facility (http://hsc.unm.edu/crtc/microscopy/facility.html). This work is funded by NIH MH080434 and MH078972).

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  1. Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA

    Changmei Liu & Xinyu Zhao

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  1. Changmei Liu
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  2. Xinyu Zhao
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Correspondence to Xinyu Zhao.

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Liu, C., Zhao, X. MicroRNAs in Adult and Embryonic Neurogenesis. Neuromol Med 11, 141–152 (2009). https://doi.org/10.1007/s12017-009-8077-y

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  • DOI: https://doi.org/10.1007/s12017-009-8077-y

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