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The Clinical Features of Sarcoidosis: A Comprehensive Review

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Abstract

Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoidosis. These manifestations are presented organ by organ, although additional sections describe systemic and multiorgan presentations of sarcoidosis. The lung is the organ most commonly involved with sarcoidosis with at least 90 % of sarcoidosis patients demonstrating lung involvement in most series. The skin, eye, liver, and peripheral lymph node are the next most commonly clinically involved organs in most series, with the frequency of involvement ranging from 10 to 30 %. The actual frequency of sarcoidosis organ involvement is probably much higher as it is frequently asymptomatic and may avoid detection. This is particularly common with lung, liver, cardiac, and bone involvement. Cardiac sarcoidosis is present in 25 % of all sarcoidosis but only causes clinical problems in 5 % of them. Nevertheless, unlike sarcoidosis involvement of most other organs, it may be suddenly fatal. Therefore, it is important to screen for cardiac sarcoidosis in all sarcoidosis patients. All sarcoidosis patients should also be screened for eye involvement as asymptomatic patients may have eye involvement that may cause permanent vision impairment. Pulmonary fibrosis from sarcoidosis is usually slowly progressive but may be life-threatening because of the development of respiratory failure, pulmonary hypertension, or hemoptysis related to a mycetoma or bronchiectasis. Some manifestations of sarcoidosis are not organ-specific and probably are the result of a release of mediators from the sarcoid granuloma. Two such manifestations include small fiber neuropathy and fatigue syndromes, and they are observed in a large percentage of patients.

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References

  1. Prasse A, Katic C, Germann M et al (2008) Phenotyping sarcoidosis from a pulmonary perspective. Am J Respir Crit Care Med 177:330–336

    CAS  PubMed  Google Scholar 

  2. Chappell AG, Cheung WY, Hutchings HA (2000) Sarcoidosis: a long-term follow up study. Sarcoidosis Vasc Diffuse Lung Dis 17:167–173

    CAS  PubMed  Google Scholar 

  3. Baughman RP, Nagai S, Balter M et al (2011) Defining the clinical outcome status (COS) in sarcoidosis: results of WASOG Task Force. Sarcoidosis Vasc Diffuse Lung Dis 28:56–64

    CAS  PubMed  Google Scholar 

  4. Shlobin OA, Nathan SD (2012) Management of end-stage sarcoidosis: pulmonary hypertension and lung transplantation. Eur Respir J 39:1520–1533

    PubMed  Google Scholar 

  5. Swigris JJ, Olson AL, Huie TJ et al (2011) Sarcoidosis-related mortality in the United States from 1988 to 2007. Am J Respir Crit Care Med 183:1524–1530

    PubMed Central  PubMed  Google Scholar 

  6. Huang CT, Heurich AE, Sutton AL et al (1981) Mortality in sarcoidosis. A changing pattern of the causes of death. Eur J Respir Dis 62:231–238

    CAS  PubMed  Google Scholar 

  7. Arcasoy SM, Christie JD, Pochettino A et al (2001) Characteristics and outcomes of patients with sarcoidosis listed for lung transplantation. Chest 120:873–880

    CAS  PubMed  Google Scholar 

  8. Tavora F, Cresswell N, Li L et al (2009) Comparison of necropsy findings in patients with sarcoidosis dying suddenly from cardiac sarcoidosis versus dying suddenly from other causes. Am J Cardiol 104:571–577

    PubMed  Google Scholar 

  9. Iwai K, Sekiguti M, Hosoda Y et al (1994) Racial difference in cardiac sarcoidosis incidence observed at autopsy. Sarcoidosis 11:26–31

    CAS  PubMed  Google Scholar 

  10. Westney GE, Judson MA (2006) Racial and ethnic disparities in sarcoidosis: from genetics to socioeconomics. Clin Chest Med 27:453–462, vi

    PubMed  Google Scholar 

  11. Sartwell PE, Edwards LB (1974) Epidemiology of sarcoidosis in the U.S. Navy. Am J Epidemiol 99:250–257

    CAS  PubMed  Google Scholar 

  12. Judson MA, Boan AD, Lackland DT (2012) The clinical course of sarcoidosis: presentation, diagnosis, and treatment in a large white and black cohort in the United States. Sarcoidosis Vasc Diffuse Lung Dis 29:119–127

    CAS  PubMed  Google Scholar 

  13. Edmondstone WM, Wilson AG (1985) Sarcoidosis in Caucasians, Blacks and Asians in London. Br J Dis Chest 79:27–36

    CAS  PubMed  Google Scholar 

  14. Reich JM, Brouns MC, O’Connor EA et al (1998) Mediastinoscopy in patients with presumptive stage I sarcoidosis: a risk/benefit, cost/benefit analysis. Chest 113:147–153

    CAS  PubMed  Google Scholar 

  15. McKinzie BP, Bullington WM, Mazur JE et al (2010) Efficacy of short-course, low-dose corticosteroid therapy for acute pulmonary sarcoidosis exacerbations. Am J Med Sci 339:1–4

    PubMed  Google Scholar 

  16. Kalkanis A, Judson MA (2013) Distinguishing asthma from sarcoidosis: an approach to a problem that is not always solvable. J Asthma 50:1–6

    PubMed  Google Scholar 

  17. Shorr AF, Torrington KG, Hnatiuk OW (2001) Endobronchial biopsy for sarcoidosis: a prospective study. Chest 120:109–114

    CAS  PubMed  Google Scholar 

  18. Highland KB, Retalis P, Coppage L et al (1997) Is there an anatomic explanation for chest pain in patients with pulmonary sarcoidosis? South Med J 90:911–914

    CAS  PubMed  Google Scholar 

  19. Nishino M, Lee KS, Itoh H et al (2010) The spectrum of pulmonary sarcoidosis: variations of high-resolution CT findings and clues for specific diagnosis. Eur J Radiol 73:66–73

    PubMed  Google Scholar 

  20. Oberstein A, von Zitzewitz H, Schweden F et al (1997) Non invasive evaluation of the inflammatory activity in sarcoidosis with high-resolution computed tomography. Sarcoidosis Vasc Diffuse Lung Dis 14:65–72

    CAS  PubMed  Google Scholar 

  21. Muller NL, Kullnig P, Miller RR (1989) The CT findings of pulmonary sarcoidosis: analysis of 25 patients. AJR Am J Roentgenol 152:1179–1182

    CAS  PubMed  Google Scholar 

  22. Hashimoto M, Watanabe O, Sato K et al (1996) The CT findings of pulmonary sarcoidosis. Tohoku J Exp Med 179:259–266

    CAS  PubMed  Google Scholar 

  23. Polychronopoulos VS, Prakash UB (2009) Airway involvement in sarcoidosis. Chest 136:1371–1380

    PubMed  Google Scholar 

  24. Yamada G, Aketa K, Takahashi H et al (2005) Endobronchial lesions of sarcoidosis. Intern Med 44:909–910

    PubMed  Google Scholar 

  25. Nunes H, Uzunhan Y, Freynet O et al (2012) Pulmonary hypertension complicating sarcoidosis. Presse Med 41:e303–316

    PubMed  Google Scholar 

  26. Lynch JP 3rd, Kazerooni EA, Gay SE (1997) Pulmonary sarcoidosis. Clin Chest Med 18:755–785

    PubMed  Google Scholar 

  27. Sones M, Israel HL (1960) Course and prognosis of sarcoidosis. Am J Med 29:84–93

    CAS  PubMed  Google Scholar 

  28. Scadding JG (1961) Prognosis of intrathoracic sarcoidosis in England. a review of 136 cases after five years’ observation. Br Med J 2:1165–1172

    CAS  PubMed Central  PubMed  Google Scholar 

  29. Mana J, Salazar A, Manresa F (1994) Clinical factors predicting persistence of activity in sarcoidosis: a multivariate analysis of 193 cases. Respiration 61:219–225

    CAS  PubMed  Google Scholar 

  30. Judson MA (2008) Sarcoidosis: clinical presentation, diagnosis, and approach to treatment. Am J Med Sci 335:26–33

    PubMed  Google Scholar 

  31. Lynch JP 3rd, Ma YL, Koss MN et al (2007) Pulmonary sarcoidosis. Semin Respir Crit Care Med 28:53–74

    PubMed  Google Scholar 

  32. Lynch JP 3rd (2003) Computed tomographic scanning in sarcoidosis. Semin Respir Crit Care Med 24:393–418

    PubMed  Google Scholar 

  33. Nishimura K, Itoh H, Kitaichi M et al (1995) CT and pathological correlation of pulmonary sarcoidosis. Semin Ultrasound CT MR 16:361–370

    CAS  PubMed  Google Scholar 

  34. Nakatsu M, Hatabu H, Morikawa K et al (2002) Large coalescent parenchymal nodules in pulmonary sarcoidosis: “sarcoid galaxy” sign. AJR Am J Roentgenol 178:1389–1393

    PubMed  Google Scholar 

  35. Brauner MW, Grenier P, Mompoint D et al (1989) Pulmonary sarcoidosis: evaluation with high-resolution CT. Radiology 172:467–471

    CAS  PubMed  Google Scholar 

  36. Abehsera M, Valeyre D, Grenier P et al (2000) Sarcoidosis with pulmonary fibrosis: CT patterns and correlation with pulmonary function. AJR Am J Roentgenol 174:1751–1757

    CAS  PubMed  Google Scholar 

  37. Mostard RL, Verschakelen JA, van Kroonenburgh MJ et al (2013) Severity of pulmonary involvement and (18)F-FDG PET activity in sarcoidosis. Respir Med 107:439–447

    PubMed  Google Scholar 

  38. Mana J, Teirstein AS, Mendelson DS et al (1995) Excessive thoracic computed tomographic scanning in sarcoidosis. Thorax 50:1264–1266

    CAS  PubMed Central  PubMed  Google Scholar 

  39. Smith-Bindman R, Lipson J, Marcus R et al (2009) Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med 169:2078–2086

    PubMed  Google Scholar 

  40. Panselinas E, Judson MA (2012) Acute pulmonary exacerbations of sarcoidosis. Chest 142:827–836

    CAS  PubMed  Google Scholar 

  41. Judson MA, Baughman RP, Thompson BW et al (2003) Two year prognosis of sarcoidosis: the ACCESS experience. Sarcoidosis Vasc Diffuse Lung Dis 20:204–211

    PubMed  Google Scholar 

  42. Baydur A, Alsalek M, Louie SG et al (2001) Respiratory muscle strength, lung function, and dyspnea in patients with sarcoidosis. Chest 120:102–108

    CAS  PubMed  Google Scholar 

  43. Winterbauer RH, Hutchinson JF (1980) Use of pulmonary function tests in the management of sarcoidosis. Chest 78:640–647

    CAS  PubMed  Google Scholar 

  44. Bergin CJ, Bell DY, Coblentz CL et al (1989) Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests. Radiology 171:619–624

    CAS  PubMed  Google Scholar 

  45. Nardi A, Brillet PY, Letoumelin P et al (2011) Stage IV sarcoidosis: comparison of survival with the general population and causes of death. Eur Respir J 38:1368–1373

    CAS  PubMed  Google Scholar 

  46. Teirstein AS, Siltzbach LE, Berger H (1976) Patterns of sarcoidosis in three population groups in New York City. Ann N Y Acad Sci 278:371–376

    CAS  PubMed  Google Scholar 

  47. Boros PW, Enright PL, Quanjer PH et al (2010) Impaired lung compliance and DL, CO but no restrictive ventilatory defect in sarcoidosis. Eur Respir J 36:1315–1322

    CAS  PubMed  Google Scholar 

  48. Baughman RP, Engel PJ, Taylor L et al (2010) Survival in sarcoidosis-associated pulmonary hypertension: the importance of hemodynamic evaluation. Chest 138:1078–1085

    PubMed  Google Scholar 

  49. Shorr AF, Davies DB, Nathan SD (2003) Predicting mortality in patients with sarcoidosis awaiting lung transplantation. Chest 124:922–928

    PubMed  Google Scholar 

  50. Handa T, Nagai S, Miki S et al (2006) Incidence of pulmonary hypertension and its clinical relevance in patients with sarcoidosis. Chest 129:1246–1252

    PubMed  Google Scholar 

  51. Smith LJ, Lawrence JB, Katzenstein AA (1983) Vascular sarcoidosis: a rare cause of pulmonary hypertension. Am J Med Sci 285:38–44

    CAS  PubMed  Google Scholar 

  52. Swigris JJ, Olson AL, Huie TJ et al (2011) Increased risk of pulmonary embolism among US decedents with sarcoidosis from 1988 to 2007. Chest 140:1261–1266

    PubMed Central  PubMed  Google Scholar 

  53. Pena TA, Soubani AO, Samavati L (2011) Aspergillus lung disease in patients with sarcoidosis: a case series and review of the literature. Lung 189:167–172

    PubMed  Google Scholar 

  54. Rafferty P, Biggs BA, Crompton GK et al (1983) What happens to patients with pulmonary aspergilloma? Analysis of 23 cases. Thorax 38:579–583

    CAS  PubMed Central  PubMed  Google Scholar 

  55. Tomlinson JR, Sahn SA (1987) Aspergilloma in sarcoid and tuberculosis. Chest 92:505–508

    CAS  PubMed  Google Scholar 

  56. Lewis MM, Mortelliti MP, Yeager H Jr et al (2002) Clinical bronchiectasis complicating pulmonary sarcoidosis: case series of seven patients. Sarcoidosis Vasc Diffuse Lung Dis 19:154–159

    PubMed  Google Scholar 

  57. Huggins JT, Doelken P, Sahn SA et al (2006) Pleural effusions in a series of 181 outpatients with sarcoidosis. Chest 129:1599–1604

    PubMed  Google Scholar 

  58. Tsiodras S, Eiger G, Guttentag A et al (1997) Sarcoidosis presenting as unilateral alveolar consolidation. Am J Med Sci 314:346–347

    CAS  PubMed  Google Scholar 

  59. Sharma SK, Soneja M, Sharma A et al (2012) Rare manifestations of sarcoidosis in modern era of new diagnostic tools. Indian J Med Res 135:621–629

    PubMed Central  PubMed  Google Scholar 

  60. Ozseker ZF, Yilmaz A, Bayramgurler B et al (2002) Cavitary sarcoidosis: analysis of two cases. Respirology 7:289–291

    PubMed  Google Scholar 

  61. Quaden C, Tillie-Leblond I, Delobbe A et al (2005) Necrotising sarcoid granulomatosis: clinical, functional, endoscopical and radiographical evaluations. Eur Respir J 26:778–785

    CAS  PubMed  Google Scholar 

  62. Churg A, Carrington CB, Gupta R (1979) Necrotizing sarcoid granulomatosis. Chest 76:406–413

    CAS  PubMed  Google Scholar 

  63. Marlow TJ, Krapiva PI, Schabel SI et al (1999) The “fairy ring”: a new radiographic finding in sarcoidosis. Chest 115:275–276

    CAS  PubMed  Google Scholar 

  64. Marchiori E, Zanetti G, Duarte Guimaraes M (2014) The reversed halo sign extending the spectrum of atypical radiological manifestations in sarcoidosis. Ann Thorac Med 9:48

    PubMed Central  PubMed  Google Scholar 

  65. Walsh SL, Roberton BJ (2010) Images in thorax. Atoll Sign Thorax 65:1029–1030

    Google Scholar 

  66. Judson MA, Uflacker R (2001) Treatment of a solitary pulmonary sarcoidosis mass by CT-guided direct intralesional injection of corticosteroid. Chest 120:316–317

    CAS  PubMed  Google Scholar 

  67. Steele JD (1963) The solitary pulmonary nodule. Report of a cooperative study of resected asymptomatic solitary pulmonary nodules in males. J Thorac Cardiovasc Surg 46:21–39

    CAS  PubMed  Google Scholar 

  68. Baughman RP, Teirstein AS, Judson MA et al (2001) Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med 164:1885–1889

    CAS  PubMed  Google Scholar 

  69. Dana MR, Merayo-Lloves J, Schaumberg DA et al (1996) Prognosticators for visual outcome in sarcoid uveitis. Ophthalmology 103:1846–1853

    CAS  PubMed  Google Scholar 

  70. Baughman RP, Lower EE, Kaufman AH (2010) Ocular sarcoidosis. Semin Respir Crit Care Med 31:452–462

    PubMed  Google Scholar 

  71. Evans M, Sharma O, LaBree L et al (2007) Differences in clinical findings between Caucasians and African Americans with biopsy-proven sarcoidosis. Ophthalmology 114:325–333

    PubMed  Google Scholar 

  72. Hunninghake GW, Costabel U, Ando M et al (1999) ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and Other Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis 16:149–173

    CAS  PubMed  Google Scholar 

  73. Ohara K, Judson MA, Baughman RP (2005) Clinical aspects of ocular sarcoidosis. Eur Respi J Monog 10:188–209

    Google Scholar 

  74. Rothova A (2000) Ocular involvement in sarcoidosis. Br J Ophthalmol 84:110–116

    CAS  PubMed Central  PubMed  Google Scholar 

  75. Bradley DA, Baughman RP, Raymond L et al (2002) Ocular manifestations of sarcoidosis. Sem Resp Crit Care Med 23:543–548

    Google Scholar 

  76. Mayers M (1990) Ocular sarcoidosis. Int Ophthalmol Clin 30:257–263

    CAS  PubMed  Google Scholar 

  77. Jabs DA, Johns CJ (1986) Ocular involvement in chronic sarcoidosis. Am J Ophthalmol 102:297–301

    CAS  PubMed  Google Scholar 

  78. Yanardag H, Pamuk ON (2003) Lacrimal gland involvement in sarcoidosis. The clinical features of 9 patients. Swiss Med Wkly 133:388–391

    PubMed  Google Scholar 

  79. Tannen BL, Kolomeyer AM, Turbin RE et al (2014) Lacrimal gland uptake of (67)Ga-gallium citrate correlates with biopsy results in patients with suspected sarcoidosis. Ocul Immunol Inflamm 22:15–22

    CAS  PubMed  Google Scholar 

  80. Prabhakaran VC, Saeed P, Esmaeli B et al (2007) Orbital and adnexal sarcoidosis. Arch Ophthalmol 125:1657–1662

    PubMed  Google Scholar 

  81. Parma ES, Abrams JE, Bhattacharjee MB et al (2002) A nodular extraocular muscle lesion in a patient with sarcoidosis. J Pediatr Ophthalmol Strabismus 39:367–368

    PubMed  Google Scholar 

  82. Marchall R, Thiers B, Judson MA. Sarcoidosis. In: Wolff K, Goldsmith LA, Katz SI, et al., eds. Fitzpatrick’s dermatology in general medicine. New York: McGraw Hill Medical, 2008; 1484-1493

  83. Eklund A, Rizzato G (2005) Skin manifestations in sarcoidosis. Eur Resp J Monog 10:150–163

    Google Scholar 

  84. Mana J, Gomez-Vaquero C, Montero A et al (1999) Lofgren’s syndrome revisited: a study of 186 patients. Am J Med 107:240–245

    CAS  PubMed  Google Scholar 

  85. Okamoto H, Mizuno K, Imamura S et al (1994) Erythema nodosum-like eruption in sarcoidosis. Clin Exp Dermatol 19:507–510

    CAS  PubMed  Google Scholar 

  86. Grunewald J, Eklund A (2009) Lofgren’s syndrome: human leukocyte antigen strongly influences the disease course. Am J Respir Crit Care Med 179:307–312

    PubMed  Google Scholar 

  87. Marchell RM, Judson MA (2007) Chronic cutaneous lesions of sarcoidosis. Clin Dermatol 25:295–302

    PubMed  Google Scholar 

  88. Haimovic A, Sanchez M, Judson MA (2012) Sarcoidosis: a comprehensive review and update for the dermatologist: part I. Cutaneous disease. J Am Acad Dermatol 66:699, e691-618; quiz 717-698

    PubMed  Google Scholar 

  89. Aubart FC, Ouayoun M, Brauner M et al (2006) Sinonasal involvement in sarcoidosis: a case–control study of 20 patients. Medicine (Baltimore) 85:365–371

    Google Scholar 

  90. Yanardag H, Pamuk ON, Karayel T (2003) Cutaneous involvement in sarcoidosis: analysis of the features in 170 patients. Respir Med 97:978–982

    PubMed  Google Scholar 

  91. Neville E, Walker AN, James DG (1983) Prognostic factors predicting the outcome of sarcoidosis: an analysis of 818 patients. Q J Med 52:525–533

    CAS  PubMed  Google Scholar 

  92. Antonovich DD, Callen JP (2005) Development of sarcoidosis in cosmetic tattoos. Arch Dermatol 141:869–872

    PubMed  Google Scholar 

  93. Chao SC, Yan JJ, Lee JY (2000) Cutaneous sarcoidosis among Taiwanese. J Formos Med Assoc 99:317–323

    CAS  PubMed  Google Scholar 

  94. Hsu S, Le EH, Khoshevis MR (2001) Differential diagnosis of annular lesions. Am Fam Physician 64:289–296

    CAS  PubMed  Google Scholar 

  95. Elgart ML (1986) Cutaneous sarcoidosis: definitions and types of lesions. Clin Dermatol 4:35–45

    CAS  PubMed  Google Scholar 

  96. Vainsencher D, Winkelmann RK (1984) Subcutaneous sarcoidosis. Arch Dermatol 120:1028–1031

    CAS  PubMed  Google Scholar 

  97. Ichiki Y, Kitajima Y (2008) Ulcerative sarcoidosis: case report and review of the Japanese literature. Acta Derm Venereol 88:526–528

    PubMed  Google Scholar 

  98. Yoo SS, Mimouni D, Nikolskaia OV et al (2004) Clinicopathologic features of ulcerative–atrophic sarcoidosis. Int J Dermatol 43:108–112

    PubMed  Google Scholar 

  99. Sharma OP, Maheshwari A, Thaker K (1993) Myocardial sarcoidosis. Chest 103:253–258

    CAS  PubMed  Google Scholar 

  100. Silverman KJ, Hutchins GM, Bulkley BH (1978) Cardiac sarcoid: a clinicopathological study of 84 unselected patients with systemic sarcoidosis. Circulation 58:1204–1211

    CAS  PubMed  Google Scholar 

  101. Birnie DH, Sauer WH, Bogun F et al (2014) HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart Rhythm 11:1305–1324

    PubMed  Google Scholar 

  102. Kim JS, Judson MA, Donnino R et al (2009) Cardiac sarcoidosis. Am Heart J 157:9–21

    CAS  PubMed  Google Scholar 

  103. Chapelon-Abric C, de Zuttere D, Duhaut P et al (2004) Cardiac sarcoidosis: a retrospective study of 41 cases. Medicine (Baltimore) 83:315–334

    Google Scholar 

  104. Smedema JP, Snoep G, van Kroonenburgh MP et al (2005) Cardiac involvement in patients with pulmonary sarcoidosis assessed at two university medical centers in The Netherlands. Chest 128:30–35

    PubMed  Google Scholar 

  105. Roberts WC, McAllister HA Jr, Ferrans VJ (1977) Sarcoidosis of the heart. a clinicopathologic study of 35 necropsy patients (group 1) and review of 78 previously described necropsy patients (group 11). Am J Med 63:86–108

    CAS  PubMed  Google Scholar 

  106. Winters SL, Cohen M, Greenberg S et al (1991) Sustained ventricular tachycardia associated with sarcoidosis: assessment of the underlying cardiac anatomy and the prospective utility of programmed ventricular stimulation, drug therapy and an implantable antitachycardia device. J Am Coll Cardiol 18:937–943

    CAS  PubMed  Google Scholar 

  107. Aizer A, Stern EH, Gomes JA et al (2005) Usefulness of programmed ventricular stimulation in predicting future arrhythmic events in patients with cardiac sarcoidosis. Am J Cardiol 96:276–282

    PubMed  Google Scholar 

  108. Viles-Gonzalez JF, Pastori L, Fischer A et al (2013) Supraventricular arrhythmias in patients with cardiac sarcoidosis prevalence, predictors, and clinical implications. Chest 143:1085–1090

    PubMed  Google Scholar 

  109. Yazaki Y, Isobe M, Hiroe M et al (2001) Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone. Am J Cardiol 88:1006–1010

    CAS  PubMed  Google Scholar 

  110. Blauwet LA, Cooper LT (2013) Idiopathic giant cell myocarditis and cardiac sarcoidosis. Heart Fail Rev 18:733–746

    PubMed  Google Scholar 

  111. Iwai K, Takemura T, Kitaichi M et al (1993) Pathological studies on sarcoidosis autopsy. II. Early change, mode of progression and death pattern. Acta Pathol Jpn 43:377–385

    CAS  PubMed  Google Scholar 

  112. Desai MY, Fallert MA (2003) Rapidly progressing congestive heart failure due to cardiac sarcoidosis involving papillary muscles: a case report and brief review of the literature. Cardiol Rev 11:163–168

    PubMed  Google Scholar 

  113. Goyal SB, Aragam JR (2006) Cardiac sarcoidosis with primary involvement of the tricuspid valve. Cardiol Rev 14:e12–13

    PubMed  Google Scholar 

  114. Gasparovic H, Bueno R, Rybicki FJ et al (2004) Sarcoidosis of the aortic root. J Thorac Cardiovasc Surg 128:761–762

    PubMed  Google Scholar 

  115. Kinney E, Murthy R, Ascunce G et al (1979) Pericardial effusions in sarcoidosis. Chest 76:476–478

    CAS  PubMed  Google Scholar 

  116. Wyplosz B, Marijon E, Dougados J et al (2010) Sarcoidosis: an unusual cause of acute pericarditis. Acta Cardiol 65:83–84

    PubMed  Google Scholar 

  117. Lam CS, Tolep KA, Metke MP et al (2009) Coronary sarcoidosis presenting as acute coronary syndrome. Clin Cardiol 32:E68–71

    PubMed  Google Scholar 

  118. Butany J, Bahl NE, Morales K et al (2006) The intricacies of cardiac sarcoidosis: a case report involving the coronary arteries and a review of the literature. Cardiovasc Pathol 15:222–227

    PubMed  Google Scholar 

  119. Abrishami B, O’Connel C, Sharma O (2004) Cardiac sarcoidosis with presentation of large left atrial mass. Curr Opin Pulm Med 10:397–400

    PubMed  Google Scholar 

  120. Ardehali H, Howard DL, Hariri A et al (2005) A positive endomyocardial biopsy result for sarcoid is associated with poor prognosis in patients with initially unexplained cardiomyopathy. Am Heart J 150:459–463

    PubMed  Google Scholar 

  121. Tadamura E, Yamamuro M, Kubo S et al (2005) Effectiveness of delayed enhanced MRI for identification of cardiac sarcoidosis: comparison with radionuclide imaging. AJR Am J Roentgenol 185:110–115

    PubMed  Google Scholar 

  122. Bulkley BH, Rouleau JR, Whitaker JQ et al (1977) The use of 201thallium for myocardial perfusion imaging in sarcoid heart disease. Chest 72:27–32

    CAS  PubMed  Google Scholar 

  123. Tellier P, Paycha F, Antony I et al (1988) Reversibility by dipyridamole of thallium-201 myocardial scan defects in patients with sarcoidosis. Am J Med 85:189–193

    CAS  PubMed  Google Scholar 

  124. Le Guludec D, Menad F, Faraggi M (1994) Myocardial sarcoidosis. Clinical value of Technetium-99m Sestamibi tomoscintigraphy. Chest 106:1675–1682

    PubMed  Google Scholar 

  125. Okayama K, Kurata C, Tawarahara K et al (1995) Diagnostic and prognostic value of myocardial scintigraphy with thallium-201 and gallium-67 in cardiac sarcoidosis. Chest 107:330–334

    CAS  PubMed  Google Scholar 

  126. Ishimaru S, Tsujino I, Takei T et al (2005) Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis. Eur Heart J 26:1538–1543

    PubMed  Google Scholar 

  127. Yokoyama I, Momomura S, Ohtake T et al (1998) Role of positron emission tomography using fluorine-18 fluoro-2-deoxyglucose in predicting improvement in left ventricular function in patients with idiopathic dilated cardiomyopathy. Eur J Nucl Med 25:736–743

    CAS  PubMed  Google Scholar 

  128. Shimada T, Shimada K, Sakane T et al (2001) Diagnosis of cardiac sarcoidosis and evaluation of the effects of steroid therapy by gadolinium-DTPA-enhanced magnetic resonance imaging. Am J Med 110:520–527

    CAS  PubMed  Google Scholar 

  129. Vignaux O, Dhote R, Duboc D et al (2002) Clinical significance of myocardial magnetic resonance abnormalities in patients with sarcoidosis: a 1-year follow-up study. Chest 122:1895–1901

    PubMed  Google Scholar 

  130. Vignaux O (2005) Cardiac sarcoidosis: spectrum of MRI features. AJR Am J Roentgenol 184:249–254

    PubMed  Google Scholar 

  131. Smedema JP, Snoep G, van Kroonenburgh MP et al (2005) Evaluation of the accuracy of gadolinium-enhanced cardiovascular magnetic resonance in the diagnosis of cardiac sarcoidosis. J Am Coll Cardiol 45:1683–1690

    PubMed  Google Scholar 

  132. Tadamura E, Yamamuro M, Kubo S et al (2006) Images in cardiovascular medicine. Multimodality imaging of cardiac sarcoidosis before and after steroid therapy. Circulation 113:e771–773

    PubMed  Google Scholar 

  133. Mehta D, Lubitz SA, Frankel Z et al (2008) Cardiac involvement in patients with sarcoidosis: diagnostic and prognostic value of outpatient testing. Chest 133:1426–1435

    PubMed  Google Scholar 

  134. Ohira H, Tsujino I, Ishimaru S et al (2008) Myocardial imaging with 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in sarcoidosis. Eur J Nucl Med Mol Imaging 35:933–941

    PubMed  Google Scholar 

  135. Ahmadian A, Brogan A, Berman J, et al. (2014) Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis. J Nucl Cardiol

  136. Isiguzo M, Brunken R, Tchou P et al (2011) Metabolism–perfusion imaging to predict disease activity in cardiac sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 28:50–55

    CAS  PubMed  Google Scholar 

  137. Sharma OP (1997) Neurosarcoidosis: a personal perspective based on the study of 37 patients. Chest 112:220–228

    CAS  PubMed  Google Scholar 

  138. Stern BJ, Krumholz A, Johns C et al (1985) Sarcoidosis and its neurological manifestations. Arch Neurol 42:909–917

    CAS  PubMed  Google Scholar 

  139. Delaney P (1977) Neurologic manifestations in sarcoidosis: review of the literature, with a report of 23 cases. Ann Intern Med 87:336–345

    CAS  PubMed  Google Scholar 

  140. Lower EE, Broderick JP, Brott TG et al (1997) Diagnosis and management of neurological sarcoidosis. Arch Intern Med 157:1864–1868

    CAS  PubMed  Google Scholar 

  141. Chen RC, McLeod JG (1989) Neurological complications of sarcoidosis. Clin Exp Neurol 26:99–112

    CAS  PubMed  Google Scholar 

  142. Nozaki K, Judson MA (2012) Neurosarcoidosis: clinical manifestations, diagnosis and treatment. Presse Med 41:e331–348

    PubMed  Google Scholar 

  143. Joseph FG, Scolding NJ (2009) Neurosarcoidosis: a study of 30 new cases. J Neurol Neurosurg Psychiatry 80:297–304

    CAS  PubMed  Google Scholar 

  144. Zajicek JP, Scolding NJ, Foster O et al (1999) Central nervous system sarcoidosis—diagnosis and management. QJM 92:103–117

    CAS  PubMed  Google Scholar 

  145. Allen RK, Sellars RE, Sandstrom PA (2003) A prospective study of 32 patients with neurosarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 20:118–125

    PubMed  Google Scholar 

  146. Colvin IB (2006) Audiovestibular manifestations of sarcoidosis: a review of the literature. Laryngoscope 116:75–82

    CAS  PubMed  Google Scholar 

  147. Takahashi T, Fujita N, Takeda K et al (2000) A case of sarcoid myopathy with external ocular muscle involvement—diagnosis and follow-up study with 99mTc pyrophosphate scintigraphy. Rinsho Shinkeigaku 40:145–148

    CAS  PubMed  Google Scholar 

  148. Biesman BS (1994) Extraocular muscle sarcoid. Ophthalmology 101:1–2

    CAS  PubMed  Google Scholar 

  149. Patel AS, Kelman SE, Duncan GW et al (1994) Painless diplopia caused by extraocular muscle sarcoid. Arch Ophthalmol 112:879–880

    CAS  PubMed  Google Scholar 

  150. Gullapalli D, Phillips LH 2nd (2004) Neurosarcoidosis. Curr Neurol Neurosci Rep 4:441–447

    PubMed  Google Scholar 

  151. Lower EE, Weiss KL (2008) Neurosarcoidosis. Clin Chest Med 29:475–492, ix

    PubMed  Google Scholar 

  152. Hoitsma E, Faber CG, Drent M et al (2004) Neurosarcoidosis: a clinical dilemma. Lancet Neurol 3:397–407

    PubMed  Google Scholar 

  153. Nozaki K, Scott TF, Sohn M et al (2012) Isolated neurosarcoidosis: case series in 2 sarcoidosis centers. Neurologist 18:373–377

    PubMed  Google Scholar 

  154. Galassi G, Gibertoni M, Mancini A et al (1984) Sarcoidosis of the peripheral nerve: clinical, electrophysiological and histological study of two cases. Eur Neurol 23:459–465

    CAS  PubMed  Google Scholar 

  155. Nemni R, Galassi G, Cohen M et al (1981) Symmetric sarcoid polyneuropathy: analysis of a sural nerve biopsy. Neurology 31:1217–1223

    CAS  PubMed  Google Scholar 

  156. Bakkers M, Merkies IS, Lauria G et al (2009) Intraepidermal nerve fiber density and its application in sarcoidosis. Neurology 73:1142–1148

    CAS  PubMed  Google Scholar 

  157. Hoitsma E, Drent M, Verstraete E et al (2003) Abnormal warm and cold sensation thresholds suggestive of small-fibre neuropathy in sarcoidosis. Clin Neurophysiol 114:2326–2333

    CAS  PubMed  Google Scholar 

  158. Tavee J, Culver D (2011) Sarcoidosis and small-fiber neuropathy. Curr Pain Headache Rep 15:201–206

    PubMed  Google Scholar 

  159. Hoitsma E, Marziniak M, Faber CG et al (2002) Small fibre neuropathy in sarcoidosis. Lancet 359:2085–2086

    CAS  PubMed  Google Scholar 

  160. Parambil JG, Tavee JO, Zhou L et al (2011) Efficacy of intravenous immunoglobulin for small fiber neuropathy associated with sarcoidosis. Respir Med 105:101–105

    PubMed  Google Scholar 

  161. Westhout FD, Linskey ME (2008) Obstructive hydrocephalus and progressive psychosis: rare presentations of neurosarcoidosis. Surg Neurol 69:288–292, discussion 292

    PubMed  Google Scholar 

  162. Krumholz A, Stern BJ, Stern EG (1991) Clinical implications of seizures in neurosarcoidosis. Arch Neurol 48:842–844

    CAS  PubMed  Google Scholar 

  163. Murialdo G, Tamagno G (2002) Endocrine aspects of neurosarcoidosis. J Endocrinol Invest 25:650–662

    CAS  PubMed  Google Scholar 

  164. Irani SK, Dobbins WO 3rd (1979) Hepatic granulomas: review of 73 patients from one hospital and survey of the literature. J Clin Gastroenterol 1:131–143

    CAS  PubMed  Google Scholar 

  165. Vatti R, Sharma OP (1997) Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases. Sarcoidosis Vasc Diffuse Lung Dis 14:73–76

    CAS  PubMed  Google Scholar 

  166. James DG, Sherlock S (1994) Sarcoidosis of the liver. Sarcoidosis 11:2–6

    CAS  PubMed  Google Scholar 

  167. Klatskin G (1977) Hepatic granulomata: problems in interpretation. Mt Sinai J Med 44:798–812

    CAS  PubMed  Google Scholar 

  168. Israel HL, Margolis ML, Rose LJ (1984) Hepatic granulomatosis and sarcoidosis. Further observations. Dig Dis Sci 29:353–356

    CAS  PubMed  Google Scholar 

  169. Devaney K, Goodman ZD, Epstein MS et al (1993) Hepatic sarcoidosis. Clinicopathologic features in 100 patients. Am J Surg Pathol 17:1272–1280

    CAS  PubMed  Google Scholar 

  170. Lehmuskallio E, Hannuksela M, Halme H (1977) The liver in sarcoidosis. Acta Med Scand 202:289–293

    CAS  PubMed  Google Scholar 

  171. Chamuleau RA, Sprangers RL, Alberts C et al (1985) Sarcoidosis and chronic intrahepatic cholestasis. Neth J Med 28:470–476

    CAS  PubMed  Google Scholar 

  172. Warshauer DM, Dumbleton SA, Molina PL et al (1994) Abdominal CT findings in sarcoidosis: radiologic and clinical correlation. Radiology 192:93–98

    CAS  PubMed  Google Scholar 

  173. Warshauer DM, Molina PL, Hamman SM et al (1995) Nodular sarcoidosis of the liver and spleen: analysis of 32 cases. Radiology 195:757–762

    CAS  PubMed  Google Scholar 

  174. Britt AR, Francis IR, Glazer GM et al (1991) Sarcoidosis: abdominal manifestations at CT. Radiology 178:91–94

    CAS  PubMed  Google Scholar 

  175. Folz SJ, Johnson CD, Swensen SJ (1995) Abdominal manifestations of sarcoidosis in CT studies. J Comput Assist Tomogr 19:573–579

    CAS  PubMed  Google Scholar 

  176. Selroos O (1976) Sarcoidosis of the spleen. Acta Med Scand 200:337–340

    CAS  PubMed  Google Scholar 

  177. Kataria YP, Whitcomb ME (1980) Splenomegaly in sarcoidosis. Arch Intern Med 140:35–37

    CAS  PubMed  Google Scholar 

  178. Sharma OP, Vucinic V, James DG (2002) Splenectomy in sarcoidosis: indications, complications, and long-term follow-up. Sarcoidosis Vasc Diffuse Lung Dis 19:66–70

    PubMed  Google Scholar 

  179. Panselinas E, Halstead L, Schlosser RJ et al (2010) Clinical manifestations, radiographic findings, treatment options, and outcome in sarcoidosis patients with upper respiratory tract involvement. South Med J 103:870–875

    PubMed  Google Scholar 

  180. Krespi YP, Mitrani M, Husain S et al (1987) Treatment of laryngeal sarcoidosis with intralesional steroid injection. Ann Otol Rhinol Laryngol 96:713–715

    CAS  PubMed  Google Scholar 

  181. Rizzato G, Montemurro L (2000) The clinical spectrum of the sarcoid peripheral lymph node. Sarcoidosis Vasc Diffuse Lung Dis 17:71–80

    CAS  PubMed  Google Scholar 

  182. Teirstein AS, Machac J, Almeida O et al (2007) Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest 132:1949–1953

    PubMed  Google Scholar 

  183. Rizzato G, Colombo P (1996) Nephrolithiasis as a presenting feature of chronic sarcoidosis: a prospective study. Sarcoidosis Vasc Diffuse Lung Dis 13:167–172

    CAS  PubMed  Google Scholar 

  184. Sharma OP (2005) Renal sarcoidosis and hypercalcemia. Eur Resp J Monog 32:220–232

    Google Scholar 

  185. Berliner AR, Haas M, Choi MJ (2006) Sarcoidosis: the nephrologist’s perspective. Am J Kidney Dis 48:856–870

    PubMed  Google Scholar 

  186. Casella FJ, Allon M (1993) The kidney in sarcoidosis. J Am Soc Nephrol 3:1555–1562

    CAS  PubMed  Google Scholar 

  187. Bell NH, Stern PH, Pantzer E et al (1979) Evidence that increased circulating 1 alpha, 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J Clin Invest 64:218–225

    CAS  PubMed Central  PubMed  Google Scholar 

  188. Adams JS, Gacad MA (1985) Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis. J Exp Med 161:755–765

    CAS  PubMed  Google Scholar 

  189. Adams JS, Sharma OP, Gacad MA et al (1983) Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest 72:1856–1860

    CAS  PubMed Central  PubMed  Google Scholar 

  190. Cremers JP, Van Kroonenburgh MJ, Mostard RL et al (2014) Extent of disease activity assessed by 18F-FDG PET/CT in a Dutch sarcoidosis population. Sarcoidosis Vasc Diffuse Lung Dis 31:37–45

    PubMed  Google Scholar 

  191. Rubini G, Cappabianca S, Altini C et al (2014) Current clinical use of 18FDG-PET/CT in patients with thoracic and systemic sarcoidosis. Radiol Med 119:64–74

    PubMed  Google Scholar 

  192. Mostard RL, Prompers L, Weijers RE et al (2012) F-18 FDG PET/CT for detecting bone and bone marrow involvement in sarcoidosis patients. Clin Nucl Med 37:21–25

    PubMed  Google Scholar 

  193. Caobelli F, Gabanelli SV, Brucato A et al (2013) Unsuspected active sarcoidosis diagnosed by 18F-FDG PET/CT during the search for a primary tumour in a patient with bone lesions. Nucl Med Mol Imaging 47:205–207

    PubMed Central  PubMed  Google Scholar 

  194. Montini KM, Tulchinsky M (2012) False-positive bone metastases on PET/CT secondary to sarcoidosis in a patient with rectal cancer. Clin Nucl Med 37:307–310

    PubMed  Google Scholar 

  195. Jansen TLTA, Geusens PPMM (2005) Sarcoidosis: joint, muscles, and bones. Eur Resp J Monog 32:210–219

    Google Scholar 

  196. Doty JD, Mazur JE, Judson MA (2005) Treatment of sarcoidosis with infliximab. Chest 127:1064–1071

    CAS  PubMed  Google Scholar 

  197. Clarencon F, Silbermann-Hoffman O, Lebreton C (2007) Diffuse spine involvement in sarcoidosis with sternal lytic lesions: two case reports. Spine 32:E594–597

    PubMed  Google Scholar 

  198. Awada H, Abi-Karam G, Fayad F (2003) Musculoskeletal and other extrapulmonary disorders in sarcoidosis. Best Pract Res Clin Rheumatol 17:971–987

    CAS  PubMed  Google Scholar 

  199. Patel A, Sun JH, Kim I et al (2013) GI tract sarcoidosis: a review. Pract Gastroenterol 37:25–38

    Google Scholar 

  200. Mahevas M, Lescure FX, Boffa JJ et al (2009) Renal sarcoidosis: clinical, laboratory, and histologic presentation and outcome in 47 patients. Medicine (Baltimore) 88:98–106

    Google Scholar 

  201. Lambert L, Riemer EC, Judson MA (2011) Rapid development of sarcoid tenosynovitis. J Clin Rheumatol 17:201–203

    PubMed  Google Scholar 

  202. El-Zawahry AM, Judson MA, Smith MT et al (2010) Genitourinary sarcoidosis: a single institution experience and review of the literature. UroToday Int J 3:1–6

    Google Scholar 

  203. Gisvold JJ, Crotty TB, Johnson RE (2000) Sarcoidosis presenting as spiculated breast masses. Mayo Clin Proc 75:293–295

    CAS  PubMed  Google Scholar 

  204. Allen SL, Judson MA (2010) Vaginal involvement in a patient with sarcoidosis. Chest 137:455–456

    PubMed  Google Scholar 

  205. JC R e S, De Sa Rosa e Silva AC, Aguiar FM (2006) Isolated endometrial polypoid sarcoidosis in a post-menopausal patient: case report. Maturitas 53:489–491

    Google Scholar 

  206. Okumus G, Musellim B, Cetinkaya E et al (2011) Extrapulmonary involvement in patients with sarcoidosis in Turkey. Respirology 16:446–450

    PubMed  Google Scholar 

  207. Judson MA, Baughman RP, Teirstein AS et al (1999) Defining organ involvement in sarcoidosis: the ACCESS proposed instrument. ACCESS research group. a case control etiologic study of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 16:75–86

    CAS  PubMed  Google Scholar 

  208. Judson MA, Costabel U, Drent M et al (2014) The WASOG sarcoidosis organ assessment instrument: an update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis 31:19–27

    PubMed  Google Scholar 

  209. de Kleijn WP, De Vries J, Lower EE et al (2009) Fatigue in sarcoidosis: a systematic review. Curr Opin Pulm Med 15:499–506

    PubMed  Google Scholar 

  210. De Vries J, Drent M (2004) Relationship between perceived stress and sarcoidosis in a Dutch patient population. Sarcoidosis Vasc Diffuse Lung Dis 21:57–63

    PubMed  Google Scholar 

  211. Gvozdenovic BS, Mihailovic-Vucinic V, Ilic-Dudvarski A et al (2008) Differences in symptom severity and health status impairment between patients with pulmonary and pulmonary plus extrapulmonary sarcoidosis. Respir Med 102:1636–1642

    PubMed  Google Scholar 

  212. De Vries J, Rothkrantz-Kos S, van Dieijen-Visser MP et al (2004) The relationship between fatigue and clinical parameters in pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 21:127–136

    PubMed  Google Scholar 

  213. De Vries J, Lower EE, Drent M (2010) Quality of life in sarcoidosis: assessment and management. Semin Respir Crit Care Med 31:485–493

    PubMed  Google Scholar 

  214. Chang B, Steimel J, Moller DR et al (2001) Depression in sarcoidosis. Am J Respir Crit Care Med 163:329–334

    CAS  PubMed  Google Scholar 

  215. Patterson KC, Huang F, Oldham JM et al (2013) Excessive daytime sleepiness and obstructive sleep apnea in patients with sarcoidosis. Chest 143:1562–1568

    PubMed  Google Scholar 

  216. Drent M, Wirnsberger RM, de Vries J et al (1999) Association of fatigue with an acute phase response in sarcoidosis. Eur Respir J 13:718–722

    CAS  PubMed  Google Scholar 

  217. De Vries J, Drent M, Van Heck GL et al (1998) Quality of life in sarcoidosis: a comparison between members of a patient organisation and a random sample. Sarcoidosis Vasc Diffuse Lung Dis 15:183–188

    PubMed  Google Scholar 

  218. De Vries J, Michielsen H, Van Heck GL et al (2004) Measuring fatigue in sarcoidosis: the fatigue assessment scale (FAS). Br J Health Psychol 9:279–291

    PubMed  Google Scholar 

  219. Kalkanis A, Yucel RM, Judson MA (2013) The internal consistency of PRO fatigue instruments in sarcoidosis: superiority of the PFI over the FAS. Sarcoidosis Vasc Diffuse Lung Dis 30:60–64

    CAS  PubMed  Google Scholar 

  220. Lower EE, Harman S, Baughman RP (2008) Double-blind, randomized trial of dexmethylphenidate hydrochloride for the treatment of sarcoidosis-associated fatigue. Chest 133:1189–1195

    CAS  PubMed  Google Scholar 

  221. Victorson DE, Cella D, Grund H, et al. A conceptual model of health-related quality of life in sarcoidosis. Qual Life Res 2013

  222. Victorson DE, Choi S, Judson MA et al (2014) Development and testing of item response theory-based item banks and short forms for eye, skin and lung problems in sarcoidosis. Qual Life Res 23:1301–1313

    PubMed  Google Scholar 

  223. Hoitsma E, De Vries J, van Santen-Hoeufft M et al (2003) Impact of pain in a Dutch sarcoidosis patient population. Sarcoidosis Vasc Diffuse Lung Dis 20:33–39

    PubMed  Google Scholar 

  224. Kobak S, Sever F, Ince O et al (2014) The prevalence of sacroiliitis and spondyloarthritis in patients with sarcoidosis. Int J Rheumatol 2014:289454

    PubMed Central  PubMed  Google Scholar 

  225. Erb N, Cushley MJ, Kassimos DG et al (2005) An assessment of back pain and the prevalence of sacroiliitis in sarcoidosis. Chest 127:192–196

    PubMed  Google Scholar 

  226. Yanardag H, Pamuk ON, Kiziltan M et al (2003) An increased frequency of carpal tunnel syndrome in sarcoidosis. Results of a study based on nerve conduction study. Acta Med (Hradec Kralove) 46:201–204

    Google Scholar 

  227. Niemer GW, Bolster MB, Buxbaum L et al (2001) Carpal tunnel syndrome in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 18:296–300

    CAS  PubMed  Google Scholar 

  228. Kersting-Sommerhoff B, Hof N, Golder W (1995) MRI of the wrist joint: “granulomatous tenovaginitis of the sarcoidosis type”—a rare cause of carpal tunnel syndrome. Rontgenpraxis 48:206–208

    CAS  PubMed  Google Scholar 

  229. De Vries J, Wirnsberger RM (2005) Fatigue, quality of life and health status in sarcoidosis. Eur Respir Mon 32:92–104

    Google Scholar 

  230. Denny MC, Fotino AD (2013) The Heerfordt–Waldenstrom syndrome as an initial presentation of sarcoidosis. Proc (Bayl Univ Med Cent) 26:390–392

    Google Scholar 

  231. Petropoulos IK, Zuber JP, Guex-Crosier Y (2008) Heerfordt syndrome with unilateral facial nerve palsy: a rare presentation of sarcoidosis. Klin Monbl Augenheilkd 225:453–456

    CAS  PubMed  Google Scholar 

  232. Evanchan J, Barreiro TJ, Gemmel D (2010) Uveitis, salivary gland swelling, and facial nerve palsy in a febrile woman. Jaapa 23(46):48–50

    Google Scholar 

  233. Judson MA (2008) The diagnosis of sarcoidosis. Clin Chest Med 29:415–427, viii

    PubMed  Google Scholar 

  234. Neville E, Mills RG, Jash DK et al (1976) Sarcoidosis of the upper respiratory tract and its association with lupus pernio. Thorax 31:660–664

    CAS  PubMed Central  PubMed  Google Scholar 

  235. James DG, Barter S, Jash D et al (1982) Sarcoidosis of the upper respiratory tract (SURT). J Laryngol Otol 96:711–718

    CAS  PubMed  Google Scholar 

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    Marc A. Judson

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Judson, M.A. The Clinical Features of Sarcoidosis: A Comprehensive Review. Clinic Rev Allerg Immunol 49, 63–78 (2015). https://doi.org/10.1007/s12016-014-8450-y

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