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Alternaria alternata and Its Allergens: a Comprehensive Review

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Abstract

Alternaria alternata is mainly an outdoor fungus whose spores disseminate in warm, dry air, so in temperate climates, their count peaks in the summers. Alternaria may also be found in damp, insufficiently ventilated houses, where its allergenic properties cocreate the sick building syndrome. Mold-induced respiratory allergies and research on Alternaria both have a lengthy history: the first was described as early as 1698 and the second dates back to 1817. However, the two were only linked in 1930 when Alternaria spores were found to cause allergic asthma. The allergenic extracts from Alternaria hyphae and spores still remain in use but are variable and insufficiently standardized as they are often a random mixture of allergenic ingredients and coincidental impurities. In contrast, contemporary biochemistry and molecular biology make it possible to obtain pure allergen molecules. To date, 16 allergens of A. alternata have been isolated, many of which are enzymes: Alt a 4 (disulfide isomerase), Alt a 6 (enolase), Alt a 8 (mannitol dehydrogenase), Alt a 10 (alcohol dehydrogenase), Alt a 13 (glutathione-S-transferase), and Alt a MnSOD (Mn superoxide dismutase). Others have structural and regulatory functions: Alt a 5 and Alt a 12 comprise the structure of large ribosomal subunits and mediate translation, Alt a 3 is a molecular chaperone, Alt a 7 regulates transcription, Alt a NTF2 facilitates protein import into the nucleus, and Alt a TCTP acts like a cytokine. The function of four allergenic proteins, Alt a 1, Alt a 2, Alt a 9, and Alt a 70 kDa, remains unknown.

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References

  1. Nees von Esenbeck CGD (1816) Das System der Pilze und Schwämme. Ein Versuch, Stahelschen Buchhandlung, Würzburg

    Google Scholar 

  2. Rotem J (1994) The genus Alternaria: biology, epidemiology, and pathogenicity. APS, Saint Paul

    Google Scholar 

  3. Wroclaw University Botanical Garden (2014) www.ogrodbotaniczny.wroclaw.pl. Accessed 4 Feb 2014

  4. Von Keißler K (1912) Zur Kenntnis der Pilzflora Krains. Beih Bot Centralbl 29:395–440

    Google Scholar 

  5. Reiss E, Shadomy HJ, Lyon GM (2011) Laboratory diagnostic methods in medical mycology—common environmental opportunistic molds and saprobic fungi occasionally present as contaminants in clinical specimens. In: Fundamental medical mycology. Wiley, Hoboken

    Google Scholar 

  6. Misaghi IJ, Grogan RG, Duniway JM, Kimble KA (1977) Influence of environment and culture media on spore morphology of Alternaria alternata. Phytopathology 68:29–34

    Article  Google Scholar 

  7. Zabawski J, Baran E (1998) Characteristics of frequent fungal pathogens and opportunistic fungi with subclasses: Zygomycotina, Ascomycotina and Deuteromycotina. In: Baran E (ed) Study of medical mycology, Wroclaw Medical University, Wrocław, vol 1. pp 37–72 [Polish]

  8. Bush RK, Prochnau JJ (2004) Case study: Alternaria-induced asthma. J Allergy Clin Immunol 113:227–234

    Article  PubMed  Google Scholar 

  9. Pose G, Patriarca A, Kyanko V, Pardo A, Fernández Pinto V (2009) Effect of water activity and temperature on growth of Alternaria alternata on a synthetic tomato medium. Int J Food Microbiol 135:60–63

    Article  CAS  PubMed  Google Scholar 

  10. Pose G, Patriarca A, Kyanko V, Pardo A, Fernández Pinto V (2010) Water activity and temperature effects on mycotoxin production by Alternaria alternata on a synthetic tomato medium. Int J Food Microbiol 142:348–353

    Article  CAS  PubMed  Google Scholar 

  11. Ren P, Ahearn DG, Crow SA Jr (1998) Mycotoxins of Alternaria alternata produced on ceiling tiles. J Ind Microbiol Biotechnol 20:53–54

    Article  CAS  PubMed  Google Scholar 

  12. Weber RW (2001) Alternaria alternata. Ann Allergy Asthma Immunol 87:A-4

    Article  CAS  Google Scholar 

  13. Kasprzyk I, Sulborska A, Nowak M et al (2013) Fluctuation range of the concentration of airborne Alternaria conidiospores sampled at different geographical locations in Poland (2010–2011). Acta Agrobot 66:65–76

    Article  Google Scholar 

  14. Krysińska-Traczyk E (2000) Microflora of the farming work environment as an occupational risk factor. Med Pr 51:351–355

    PubMed  Google Scholar 

  15. Prester L (2011) Indoor exposure to mould allergens. Arh Hig Rada Toksikol 62:371–380

    PubMed  Google Scholar 

  16. Peters JL, Muilenberg ML, Rogers CA, Burge HA, Spengler JD (2008) Alternaria measures in inner-city, low-income housing by immunoassay and culture-based analysis. Ann Allergy Asthma Immunol 100:364–369

    Article  PubMed  Google Scholar 

  17. Ishibashi M, Tonori H, Miki T et al (2007) Classification of patients complaining of sick house syndrome and/or multiple chemical sensitivity. Tohoku J Exp Med 211:223–233

    Article  PubMed  Google Scholar 

  18. O’Connor GT, Walter M, Mitchell H et al (2004) Airborne fungi in the homes of children with asthma in low-income urban communities: the Inner-City Asthma Study. J Allergy Clin Immunol 114:599–606

    Article  PubMed  Google Scholar 

  19. Barnes C, Portnoy J, Sever S, Arbes S Jr, Vaughn B, Zeldin DC (2006) Comparison of enzyme immunoassay-based assays for environmental Alternaria alternata. Ann Allergy Asthma Immunol 97:350–356

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Pavon Moreno MA, Gonzalez Alonso I, de Martin Santos R, Garcia LT (2012) The importance of genus Alternaria in mycotoxins production and human diseases. Nutr Hosp 27:1772–1781, Spanish

    CAS  PubMed  Google Scholar 

  21. Edmondson DA, Nordness ME, Zacharisen MC, Kurup VP, Fink JN (2005) Allergy and “toxic mold syndrome”. Ann Allergy Asthma Immunol 9:234–239

    Article  Google Scholar 

  22. Simon-Nobbe B, Denk U, Poell V, Rid R, Breitenbach M (2008) The spectrum of fungal allergy. Int Arch Allergy Immunol 145:58–86

    Article  PubMed  Google Scholar 

  23. D’Amato G, Chatzigeorgiou G, Corsico R et al (1997) Evaluation of the prevalence of skin prick test positivity to Alternaria and Cladosporium in patients with suspected respiratory allergy. A European multicenter study promoted by the Subcommittee on Aerobiology and Environmental Aspects of Inhalant Allergens of the European Academy of Allergology and Clinical Immunology. Allergy 52:711–716

    Article  PubMed  Google Scholar 

  24. Bogacka E, Nittner-Marszalska M, Fal AM, Kuzniar J, Nikiel E, Malolepszy J (2003) Allergy to mould allergens as a risk factor for bronchial asthma in patients suffering from allergic rhinitis. Pol Merkuriusz Lek 14:388–392 [Polish]

    Google Scholar 

  25. Rapiejko P, Lipiec A, Wojdas A, Jurkiewicz D (2004) Threshold pollen concentration necessary to evoke allergic symptoms. Int Rev Allergol Clin 10:91–94

    Google Scholar 

  26. Lipiec A, Rapiejko P, Modrzyński M et al (2006) Alternaria spors in the air of selected Polish cities in 2005. Alergoprofil 2:45–50 [Polish]

    Google Scholar 

  27. Malkiewicz M (2010) Alternaria spores in the air in Wroclaw in 2010. Alergoprofil 6:65–66 [Polish]

    Google Scholar 

  28. Matsuwaki Y, Wada K, White T, Moriyama H, Kita H (2012) Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2. Int Arch Allergy Immunol 158:19–29

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Reed CE, Kita H (2004) The role of protease activation of inflammation in allergic respiratory diseases. J Allergy Clin Immunol 114:997–1008

    Article  CAS  PubMed  Google Scholar 

  30. Knight DA, Lim S, Scaffidi AK et al (2001) Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J Allergy Clin Immunol 108:797–803

    Article  CAS  PubMed  Google Scholar 

  31. Kim HK, Lund S, Baum R, Rosenthal P, Khorram M, Doherty TA (2014) Innate type 2 response to Alternaria extract enhances ryegrass-induced lung inflammation. Int Arch Allergy Immunol 163:92–105

    Article  CAS  PubMed  Google Scholar 

  32. Kouzaki H, Iijima K, Kobayashi T, O’Grady SM, Kita H (2011) The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol 186:4375–4387

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Postigo I, Gutiérrez-Rodríguez A, Fernández J, Guisantes JA, Suñén E, Martínez J (2011) Diagnostic value of Alt a 1, fungal enolase and manganese-dependent superoxide dismutase in the component-resolved diagnosis of allergy to Pleosporaceae. Clin Exp Allergy 41:443–451

    Article  CAS  PubMed  Google Scholar 

  34. Wagner S, Breiteneder H, Simon-Nobbe B et al (2000) Hev b 9, an enolase and a new cross-reactive allergen from Hevea latex and molds. Purification, characterization, cloning and expression. Eur J Biochem 267:7006–7014

    Article  CAS  PubMed  Google Scholar 

  35. Floyer J (1698) A treatise of the asthma, 1st edn. Wirkin & Inngs, London

    Google Scholar 

  36. Ainsworth GC (1987) Introduction to the history of medical and veterinary mycology. Cambridge University Press, Cambridge

    Google Scholar 

  37. Denning DW, O’Driscoll BR, Hogaboam CM, Bowyer P, Niven RM (2006) The link between fungi and severe asthma: a summary of the evidence. Eur Respir J 27:615–626

    Article  CAS  PubMed  Google Scholar 

  38. Hopkins JG, Benham RW, Kesten BM (1930) Asthma due to a fungus Alternaria. JAMA 94:6–10

    Article  Google Scholar 

  39. Hauser M, Roulias A, Ferreira F, Egger M (2010) Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol 6:1

    Article  PubMed Central  PubMed  Google Scholar 

  40. Mari A (2008) When does a protein become an allergen? Searching for a dynamic definition based on most advanced technology tools. Clin Exp Allergy 38:1089–1094

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  41. Kustrzeba-Wójcicka I, Golczak M (2000) Enolase from Candida albicans—purification and characterization. Comp Biochem Physiol B Biochem Mol Biol 126:109–120, 32

    Article  PubMed  Google Scholar 

  42. Kustrzeba-Wójcicka I, Kmiecik W (2001) Studies on enolase—a principal allergen of moulds. Preparation and characteristic s of enolase from Alternaria alternata. Med Myc 8:141–145 [Polish]

    Google Scholar 

  43. Kustrzeba-Wójcicka I (2009) Enolase-mold panallergen: a comparative characterization of enolase as an allergen of chosen species of fungi. DSc thesis, Wroclaw Medical University, Wrocław, Poland [Polish]

  44. Canonica GW, Ansotegui IJ, Pawankar R et al (2013) A WAO-ARIA-GA2LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J 6:17

    Article  PubMed Central  PubMed  Google Scholar 

  45. Sastre J (2010) Molecular diagnosis in allergy. Clin Exp Allergy 40:1442–1460

    Article  CAS  PubMed  Google Scholar 

  46. Thermo Fisher Scientific Inc. (Phadia AB) (2014) http://www.phadia.com. Accessed 6 Feb 2014

  47. Chapman MD (2003) Allergen nomenclature. In: Lockey RF, Bukantz SC, Bousquet J (eds) Allergens and allergen immunotherapy, vol 1. Marcel Dekker, New York, pp 51–64

  48. Chapman MD, Pomes A, Breiteneder H, Ferreira F (2007) Nomenclature and structural biology of allergens. J Allergy Clin Immunol 119:414–420

    Article  CAS  PubMed  Google Scholar 

  49. WHO/IUIS Sub-committee on Allergen Nomenclature (2014) www.allergen.org. Accessed 6 Feb 2014

  50. Allergome, the Platform for Allergen Knowledge (2014) http://www.allergome.org. Accessed 6 Feb 2014

  51. Mari A, Scala E, Palazzo P, Ridolfi S, Zennaro D, Carabella G (2006) Bioinformatics applied to allergy: allergen databases, from collecting sequence information to data integration. The Allergome platform as a model. Cell Immunol 244:97–100

    Article  CAS  PubMed  Google Scholar 

  52. Deards MJ, Montague AE (1991) Purification and characterisation of a major allergen of Alternaria alternata. Mol Immunol 28:409–415, 33

    Article  CAS  PubMed  Google Scholar 

  53. Zhang L, Curran IH, Muradia G, De Vouge MW, Rode H, Vijay HM (1995) N-terminus of a major allergen, Alt a I, of Alternaria alternata defined to be an epitope. Int Arch Allergy Immunol 108:254–259

    Article  CAS  PubMed  Google Scholar 

  54. De Vouge MW, Thaker AJ, Curran IH et al (1996) Isolation and expression of a cDNA clone encoding an Alternaria alternata Alt a 1 subunit. Int Arch Allergy Immunol 111:385–395

    Article  PubMed  Google Scholar 

  55. De Vouge MW, Thaker AJ, Zhang L, Muradia G, Rode H, Vijay HM (1998) Molecular cloning of IgE-binding fragments of Alternaria alternata allergens. Int Arch Allergy Immunol 116:261–268

    Article  PubMed  Google Scholar 

  56. Unger A, Stoger P, Simon-Nobbe B et al (1999) Clinical testing of recombinant allergens of the mold Alternaria alternata. Int Arch Allergy Immunol 118:220–221

    Article  CAS  PubMed  Google Scholar 

  57. Vailes LD, Perzanowski MS, Wheatley LM, Platts-Mills TA, Chapman MD (2001) IgE and IgG antibody responses to recombinant Alt a 1 as a marker of sensitization to Alternaria in asthma and atopic dermatitis. Clin Exp Allergy 31:1891–1895

    Article  CAS  PubMed  Google Scholar 

  58. Asturias JA, Ibarrola I, Ferrer A et al (2005) Diagnosis of Alternaria alternata sensitization with natural and recombinant Alt a 1 allergens. J Allergy Clin Immunol 115:1210–1217

    Article  CAS  PubMed  Google Scholar 

  59. Chruszcz M, Chapman MD, Osinski T et al (2012) Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi. J Allergy Clin Immunol 130:241–247

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  60. Twaroch TE, Arcalís E, Sterflinger K, Stöger E, Swoboda I, Valenta R (2012) Predominant localization of the major Alternaria allergen Alt a 1 in the cell wall of airborne spores. J Allergy Clin Immunol 129:1148–1149, 34

    Article  CAS  PubMed  Google Scholar 

  61. Twaroch TE, Focke M, Fleischmann K et al (2012) Carrier-bound Alt a 1 peptides without allergenic activity for vaccination against Alternaria alternata allergy. Clin Exp Allergy 42:966–975

    CAS  PubMed  Google Scholar 

  62. Mechaly AE, Ibanez de Opakua A, Asturias J, Viguera AR (2013) Crystal structure of Alternaria alternata major allergen Alt a 1. Allergy 68:126–127

    Google Scholar 

  63. Wagner GE, Gutfreund S, Fauland K, Keller W, Valenta R, Zangger K (2013) Backbone resonance assignment of Alt a 1, a unique β-barrel protein and the major allergen of Alternaria alternata. Biomol NMR Assign. doi:10.1007/s12104-013-9489-z

    Google Scholar 

  64. Protein Knowledgebase (2014) www.uniprot.org. Accessed 10 Feb 2014

  65. Bush RK, Sanchez H, Geisler D (1999) Molecular cloning of a major Alternaria alternata allergen, rAlt a 2. J Allergy Clin Immunol 104:665–671

    Article  CAS  PubMed  Google Scholar 

  66. Breitenbach M, Simon-Nobbe B (2002) The allergens of Cladosporium herbarum and Alternaria alternata. In: Breitenbach M, Crameri R, Lehrer SB (eds) Fungal allergy and pathogenicity. Chem Immunol, vol 81. Karger, Basel, pp 48–72

  67. Kiang JG, Tsokos GC (1998) Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 80:183–201

    Article  CAS  PubMed  Google Scholar 

  68. Achatz G, Oberkofler H, Lechenauer E et al (1995) Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum. Mol Immunol 32:213–227

    Article  CAS  PubMed  Google Scholar 

  69. Achatz G, Oberkofler H, Lechenauer E et al (1996) Molecular characterization of Alternaria alternata and Cladosporium herbarum allergens. Adv Exp Med Biol 409:157–161

    Article  CAS  PubMed  Google Scholar 

  70. Wilkinson B, Gilbert HF (2004) Protein disulfide isomerase. Biochim Biophys Acta 1699:35–44

    Article  CAS  PubMed  Google Scholar 

  71. Tchórzewski M (2002) The acidic ribosomal P proteins. Int J Biochem Cell Biol 34:911–915

    Article  PubMed  Google Scholar 

  72. Lohman K, Meyerhof O (1934) Enzymatic transformation of phosphoglyceric acid into pyruvic acid and phosphoric acid. Biochem Z 273:60–72

    Google Scholar 

  73. Pancholi V (2001) Multifunctional α-enolase: its role in diseases. Cell Mol Life Sci 58:902–920

    Article  CAS  PubMed  Google Scholar 

  74. Díaz-Ramos À, Roig-Borrellas A, García-Melero A, López-Alemany R (2012) α-Enolase, a multifunctional protein: its role on pathophysiological situations. J Biomed Biotechnol. Article ID 156795. http://dx.doi.org/10.1155/2012/156795. Accessed 14 Feb 2014

  75. Baldo BA, Baker RS (1988) Inhalant allergies to fungi: reactions to bakers’ yeast (Saccharomyces cerevisiae) and identification of bakers’ yeast enolase as an important allergen. Int Arch Allergy Appl Immunol 86:201–208

    Article  CAS  PubMed  Google Scholar 

  76. Nittner-Marszalska M, Kustrzeba-Wójcicka I, Bogacka E, Patkowski J, Dobek R (2001) Skin prick test response to enzyme enolase of the baker’s yeast (Saccharomyces cerevisiae) in diagnosis of respiratory allergy. Med Sci Monit 7:121–124

    CAS  PubMed  Google Scholar 

  77. Breitenbach M, Simon B, Probst G et al (1997) Enolases are highly conserved fungal allergens. Int Arch Allergy Immunol 113:114–117

    Article  CAS  PubMed  Google Scholar 

  78. Simon-Nobbe B, Probst G, Kajava AV et al (2000) IgE-binding epitopes of enolases, a class of highly conserved fungal allergens. J Allergy Clin Immunol 106:887–895

    Article  CAS  PubMed  Google Scholar 

  79. Piast M, Kustrzeba-Wójcicka I, Matusiewicz M, Banaś T (2005) Molecular evolution of enolase. Acta Biochim Pol 52:507–513

    CAS  PubMed  Google Scholar 

  80. Saccharomyces Genome Database (2014) www.yeastgenome.org. Accessed 11 Feb 2014

  81. Simondsen RP, Tollin G (1980) Structure-function relations in flavodoxins. Mol Cell Biochem 33:13–24

    Article  CAS  PubMed  Google Scholar 

  82. Sancho J (2006) Flavodoxins: sequence, folding, binding, function and beyond. Cell Mol Life Sci 63:855–864

    Article  CAS  PubMed  Google Scholar 

  83. Cardona F, Orozco H, Friant S, Aranda A, del Olmo MI (2011) The Saccharomyces flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism. Arch Microbiol 193:515–525

    Article  CAS  PubMed  Google Scholar 

  84. Schneider PB, Denk U, Breitenbach M et al (2007) Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen. Clin Exp Allergy 36:1513–1524

    Article  Google Scholar 

  85. Vélëz H, Glassbrook NJ, Daub ME (2007) Mannitol metabolism in the phytopathogenic fungus Alternaria alternata. Fung Genet Biol 44:258–268

    Article  Google Scholar 

  86. Vélëz H, Ehrenshaft M, Daub ME (2008) Alternaria alternata mannitol metabolism in plant-pathogen interactions. FEMS Microbiol Lett 285:122–129

    Article  PubMed  Google Scholar 

  87. Breitenbach M, Achatz G, Oberkofler H et al (1995) Molecular characterization of allergens of Cladosporium herbarum and Alternaria alternans. Int Arch Allergy Immunol 107:458–459

    Article  CAS  PubMed  Google Scholar 

  88. Pietruszko R, Kurys G, Ambroziak W (1991) Physiological role of aldehyde dehydrogenase (EC 1.2. 1.3. In: Palmer TN (ed) Alcoholism: a molecular perspective, vol 206. Plenum, New York, pp 101–106

    Chapter  Google Scholar 

  89. Shankar J, Singh BP, Gaur SN, Arora N (2006) Recombinant glutathione-S-transferase a major allergen from Alternaria alternata for clinical use in allergy patients. Mol Immunol 43:1927–1932

    Article  CAS  PubMed  Google Scholar 

  90. Shankar J, Gupta PD, Sridhara S, Singh BP, Gaur SN, Arora N (2005) Immunobiochemical analysis of cross-reactive glutathione-S-transferase allergen from different fungal sources. Immunol Invest 34:37–51

    Article  CAS  PubMed  Google Scholar 

  91. Shankar J, Singh BP, Gaur SN, Arora N (2009) Engineered Alt a 13 fragment of Alternaria alternata abrogated IgE binding without affecting T-cell stimulation. J Clin Immunol 29:63–70

    Article  CAS  PubMed  Google Scholar 

  92. Hogue E, Pflugmacher S, Fritscher J, Wolf M (2007) Induction of glutathione S-transferase in biofilms and germinating spores of Mucor hiemalis strain EH5 from cold sulfidic spring waters. Appl Environ Microbiol 73:2697–2707

    Article  Google Scholar 

  93. Portnoy J, Olson I, Pacheco F, Barnes C (1990) Affinity purification of a major Alternaria allergen using a monoclonal antibody. Ann Allergy 65:109–114

    CAS  PubMed  Google Scholar 

  94. Crameri R (2011) The problem of cross-reactivity in the diagnosis of fungal allergy. Clin Exp Allergy 41:302–304

    Article  CAS  PubMed  Google Scholar 

  95. Weichel M, Schmid-Grendelmeier P, Fluckiger S, Breitenbach M, Blaser K, Crameri R (2003) Nuclear transport factor 2 represents a novel cross-reactive fungal allergen. Allergy 58:198–206

    Article  CAS  PubMed  Google Scholar 

  96. Paschal BM, Gerace L (1995) Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. J Cell Biol 129:925–937

    Article  CAS  PubMed  Google Scholar 

  97. MacDonald SM, Rafnar T, Langdon J, Lichtenstein LM (1995) Molecular identification of an IgE-dependent histamine-releasing factor. Science 269:688–690

    Article  CAS  PubMed  Google Scholar 

  98. Li F, Zhang D, Fujise K (2001) Characterization of fortilin, a novel antiapoptotic protein. J Biol Chem 276:47542–47549

    Article  CAS  PubMed  Google Scholar 

  99. Bommer UA, Thiele BJ (2004) The translationally controlled tumour protein (TCTP). Int J Biochem Cell Biol 36:379–385

    Article  CAS  PubMed  Google Scholar 

  100. Rid R, Simon-Nobbe B, Langdon J et al (2008) Cladosporium herbarum translationally controlled tumor protein (TCTP) is an IgE-binding antigen and is associated with disease severity. Mol Immunol 45:406–418

    Article  CAS  PubMed  Google Scholar 

  101. Rid R, Onder K, Macdonald S et al (2009) Alternaria alternata TCTP, a novel cross-reactive ascomycete allergen. Mol Immunol 46:3476–3487

    Article  CAS  PubMed  Google Scholar 

  102. Bommer UA, Heng C, Perrin A et al (2010) Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses. Oncogene 29:763–773

    Article  CAS  PubMed  Google Scholar 

  103. Brioudes F, Thierry AM, Chambrier P, Mollereau B, Bendahmane M (2010) Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants. Proc Natl Acad Sci U S A 107:16384–16389

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  104. Kashiwakura JC, Ando T, Matsumoto K et al (2012) Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest 122:218–228

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  105. Kim M, Maeng J, Lee K (2013) Dimerization of TCTP and its clinical implications for allergy. Biochimie 95:659–666

    Article  CAS  PubMed  Google Scholar 

  106. Bowyer P, Fraczek M, Denning DW (2006) Comparative genomics of fungal allergens and epitopes shows widespread distribution of closely related allergen and epitope orthologues. BMC Genomics 7:251

    Article  PubMed Central  PubMed  Google Scholar 

  107. Mari A, Schneider P, Wally V, Breitenbach M, Simon-Nobbe B (2003) Sensitization to fungi: epidemiology, comparative skin tests, and IgE reactivity of fungal extracts. Clin Exp Allergy 33:1429–1438

    Article  CAS  PubMed  Google Scholar 

  108. Cox L, Aaronson D, Casale TB, Honsinger R, Weber R (2013) Allergy immunotherapy safety: location matters! J Allergy Clin Immunol Pract 1:455–457

    Article  PubMed  Google Scholar 

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Conflict of Interest

Irena Kustrzeba-Wójcicka, Emilia Siwak, Grzegorz Terlecki, Anna Wolańczyk-Mędrala, and Wojciech Mędrala declare that they have no conflict of interest.

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  1. Department of Medical Biochemistry, Wrocław Medical University, Chałubińskiego10, 50-368, Wrocław, Poland

    Irena Kustrzeba-Wójcicka, Emilia Siwak & Grzegorz Terlecki

  2. Department of Internal Diseases, Geriatrics and Allergology, Wrocław Medical University, Wrocław, Poland

    Emilia Siwak, Anna Wolańczyk-Mędrala & Wojciech Mędrala

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Kustrzeba-Wójcicka, I., Siwak, E., Terlecki, G. et al. Alternaria alternata and Its Allergens: a Comprehensive Review. Clinic Rev Allerg Immunol 47, 354–365 (2014). https://doi.org/10.1007/s12016-014-8447-6

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