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Endothelial Progenitor Cells in Autoimmune Disorders

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Abstract

Circulating endothelial progenitor cells (EPCs) were first described in 1997 by Asahara et al. as “putative endothelial cells” from human peripheral blood. The study of endothelial progenitors is also intensifying in several pathologies associated with endothelial damage, including diabetes, myocardial infarction, sepsis, pulmonary arterial hypertension, obstructive bronchopneumopathy and transplantation. EPCs have been studied in several autoimmune diseases with endothelial involvement such as systemic lupus erythematosus, thrombotic thrombocytopenic purpura, antineutrophil cytoplasmic antibodies, vasculitis, rheumatoid arthritis, Goujerot-Sjögren and antiphospholipid syndrome. Factors involved in endothelial damage are due to overexpression of pro-inflammatory cytokines and/or autoantibodies. Management of these pathologies, particularly the long-term use of glucocorticoids and methotrexate, promote atherosclerosis. A lack of standardized assessment of the number and function of EPCs represents a serious challenge for the use of EPCs as prognostic markers of cardiovascular diseases (CVD). The objective of this review was to describe EPCs, their properties and their involvement in several autoimmune diseases.

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Acknowledgements

Authors are grateful to Nikki Sabourin-Gibbs, CHU Rouen, for her help in editing the manuscript.

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Authors and Affiliations

  1. UNIROUEN, INSERM U1096 EnVI, CHU Rouen, Department of General Biochemistry, Normandie University, F-76000, Rouen, France

    Guillaume Feugray

  2. UNIROUEN, INSERM U1096, CHU Rouen. Department of Internal Medicine, Normandie University, Rouen, France

    Sébastien Miranda & Paul Billoir

  3. Normandy Univ, U1096, Rouen University Hospital, Vascular Hemostasis Unit, Rouen, France

    Véronique Le Cam Duchez & Paul Billoir

  4. UNIROUEN, INSERM U1096 EnVI, CHU Rouen, Department of Pharmacology, Normandie University, F-76000, Rouen, France

    Jérémy Bellien

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G Feugray and P Billoir wrote the manuscript, analyzed and interpreted the data. S Miranda, V Lecam Duchez and J Bellien revised the manuscript and results. All authors have read and approved the final version of the manuscript.

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Feugray, G., Miranda, S., Le Cam Duchez, V. et al. Endothelial Progenitor Cells in Autoimmune Disorders. Stem Cell Rev and Rep 19, 2597–2611 (2023). https://doi.org/10.1007/s12015-023-10617-y

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