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Liver Buds and Liver Organoids: New Tools for Liver Development, Disease and Medical Application

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Abstract

The current understanding and effective treatment of liver disease is far from satisfactory. Liver organoids and liver buds (LBs) transforming cell culture from two dimensions(2D) to three dimensions(3D) has provided infinite possibilities for stem cells to use in clinic. Recent technological advances in the 3D culture have shown the potentiality of liver organoids and LBs as the promising tool to model in vitro liver diseases. The induced LBs and liver organoids provide a platform for cell-based therapy, liver disease models, liver organogenesis and drugs screening. And its genetic heterogeneity supplies a way for the realization of precision medicine.

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Acknowledgements

We thank Dr. Xiaoping Xu and Yuan Chen for help in discussion on field liver bud and organoid.

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Funding

This work was supported by the National Natural Science Foundation of China (81470875), Science and Technology Planning Project of Guangdong Province (2015B020229002, 2014B020227002), and the Natural Science Foundation of Guangdong Province (2014A030312013).

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Authors and Affiliations

  1. Second Department of Hepatobiliary Surgery, Zhujiang Hospital, State Key Laboratory of Organ Failure Research, Co-Innovation Center for Organ Failure Research, Southern Medical University, 253 Gongye Street, Haizhu, Guangzhou, 510280, China

    Fanhong Zeng, Yue Zhang, Xu Han, Jun Weng & Yi Gao

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  1. Fanhong Zeng
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  2. Yue Zhang
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  3. Xu Han
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  4. Jun Weng
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Weng Jun conceptualized the discussions. Fanhong Zeng wrote the manuscript under the supervision of Gao Yi. Yue Zhang and Xu Han edited the manuscript. All authors read and approved the final manuscript.

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Correspondence to Jun Weng or Yi Gao.

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Fanhong Zeng, Yue Zhang, Xu Han, Jun Weng, and Yi Gao are co-authors

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Zeng, F., Zhang, Y., Han, X. et al. Liver Buds and Liver Organoids: New Tools for Liver Development, Disease and Medical Application. Stem Cell Rev and Rep 15, 774–784 (2019). https://doi.org/10.1007/s12015-019-09909-z

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