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Cardiac Cell Therapy: Boosting Mesenchymal Stem Cells Effects

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Abstract

Acute myocardial infarction is a major problem of world public health and available treatments have limited efficacy. Cardiac cell therapy is a new therapeutic strategy focused on regeneration and repair of the injured cardiac muscle. Among different cell types used, mesenchymal stem cells (MSC) have been widely tested in preclinical studies and several clinical trials have evaluated their clinical efficacy in myocardial infarction. However, the beneficial effects of MSC in humans are limited due to poor engraftment and survival of these cells, therefore ways to overcome these obstacles should improve efficacy. Different strategies have been used, such as genetically modifying MSC, or preconditioning the cells with factors that potentiate their survival and therapeutic mechanisms. In this review we compile the most relevant approaches used to improve MSC therapeutic capacity and to understand the molecular mechanisms involved in MSC mediated cardiac repair.

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Acknowledgments

This work was supported by grants from Instituto de Salud Carlos III (CP08/80 and PI07/784) and from Obra Social Kutxa. P. Sepúlveda is the recipient of a contract from the Instituto de Salud Carlos III. E. Samper is a predoctoral fellow from the Centro de Investigación Príncipe Felipe.

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The authors declare no potential conflicts of interest.

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Authors and Affiliations

  1. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Fundación Hospital La Fe, Valencia, Spain

    E. Samper, J. A. Montero & P. Sepúlveda

  2. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Centro Investigación Príncipe Felipe, Valencia, Spain

    A. Diez-Juan

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  1. E. Samper
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Samper, E., Diez-Juan, A., Montero, J.A. et al. Cardiac Cell Therapy: Boosting Mesenchymal Stem Cells Effects. Stem Cell Rev and Rep 9, 266–280 (2013). https://doi.org/10.1007/s12015-012-9353-z

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