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oxLDL-Induced Lipid Accumulation in Glomerular Podocytes: Role of IFN-γ, CXCL16, and ADAM10

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Abstract

Previous studies have shown that lipid accumulation plays an important role in the pathogenesis and development of glomerular sclerosis. oxLDL caused damage in renal mesangial cells, endothelial cells, and podocytes, and podocytes might be the major victim of oxLDL insult. However, the regulatory mechanism of how oxLDL induces the damage of podocytes remains to be elucidated. In this study, oil red staining was used to investigate the lipid accumulation in podocytes. Moreover, the effects of CXCL16 antibody, IFN-γ, and ADAM10 inhibitor on oxLDL intake and CXCL16 expression were also explored to elucidate the regulatory factors of lipid accumulation in podocytes.

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Acknowledgments

This study was supported by Shandong Province Natural Science Foundation (No. ZR2010HM110).

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Authors and Affiliations

  1. Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, People’s Republic of China

    Li Wang, Shuzhen Sun, Aihua Zhou, Xiujun Yao & Yulin Wang

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  1. Li Wang
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  2. Shuzhen Sun
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  3. Aihua Zhou
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  4. Xiujun Yao
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  5. Yulin Wang
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Correspondence to Yulin Wang.

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Wang, L., Sun, S., Zhou, A. et al. oxLDL-Induced Lipid Accumulation in Glomerular Podocytes: Role of IFN-γ, CXCL16, and ADAM10. Cell Biochem Biophys 70, 529–538 (2014). https://doi.org/10.1007/s12013-014-9952-1

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  • DOI: https://doi.org/10.1007/s12013-014-9952-1

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