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Effects of Adaptive Support Ventilation and Synchronized Intermittent Mandatory Ventilation on Peripheral Circulation and Blood Gas Markers of COPD Patients with Respiratory Failure

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Abstract

The objective of the study was to investigate the effects of adaptive support ventilation (ASV) and synchronized intermittent mandatory ventilation (SIMV) on peripheral circulation of chronic obstructive pulmonary disease (COPD) patients with respiratory failure. 86 COPD patients with respiratory failure were recruited in this study. Self-control method was used to compare the effect of ASV and SIMV on the parameters of ventilation machine, heart rate, blood pressure, central venous pressure (CVP), and blood gas markers. When the patients in ASV and SIMV groups were compared, respiratory rate, tidal volume, and peak airway pressure (PIP) showed significant difference. When minute ventilation (MV) was compared, no significant difference was shown. When peripheral circulation parameters were compared, peripheral circulation heart rate, SBP, DBP, and CVP showed significant difference. Compared with SIMV group, PaO2, pH, and SaO2 values were remarkably increased (P < 0.01) while no significant difference was found for partial pressure of carbon dioxide (pCO2) when two groups were compared. In conclusion, when mechanical ventilation was used in COPD patients with respiratory failure, ASV can significantly improve clinical outcomes.

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Authors and Affiliations

  1. Department of Respiration, Jilin University 1st Hospital, No. 71, Xinmin Road, Changchun, 130021, Jilin, China

    Ling Han & Lijun Xu

  2. People’s Hospital of Jilin Province, Changchun, Jilin, China

    Ling Han, Yingxiao Wang & Yonghua Gan

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  1. Ling Han
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  2. Yingxiao Wang
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  3. Yonghua Gan
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  4. Lijun Xu
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Correspondence to Lijun Xu.

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Han, L., Wang, Y., Gan, Y. et al. Effects of Adaptive Support Ventilation and Synchronized Intermittent Mandatory Ventilation on Peripheral Circulation and Blood Gas Markers of COPD Patients with Respiratory Failure. Cell Biochem Biophys 70, 481–484 (2014). https://doi.org/10.1007/s12013-014-9944-1

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  • DOI: https://doi.org/10.1007/s12013-014-9944-1

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