Abstract
The purpose of this study is to investigate the diagnostic value of transvaginal sonograph (TVS), color Doppler, and serum tumor marker CA125, CEA, and AFP in ovarian cancer. From June, 2011 to May, 2013, 102 cases with adnexal mass were recruited in this study (32 cases of malignant ovarian cancer and 70 cases of benign ovarian tumor according to pathological diagnosis). TVS, color Doppler, and serum tumor markers were used for tumor diagnosis. The sensitivity, specifity, positive prediction, negative prediction, and Youden’s index were analyzed. Of the 102 patients, 32 were diagnosed with malignant ovarian cancer and 70 were diagnosed with benign ovarian tumor according to pathological diagnosis. Based on TVS results, 37 cases were malignant while 65 cases were benign. Based on color Doppler results, 34 cases were malignant while 68 cases were benign. Based on TVS and color Doppler results, 35 cases were malignant while 65 were benign. Based on CA125 test results, 34 cases were malignant while 68 cases were benign. Based on CEA test results, 8 cases were malignant and 94 cases were benign. Bases on AFP test results, 9 cases were malignant while 93 cases were benign. Based on the results of combination tumor marker test, 38 cases were malignant while 64 cases were benign. The combination of TVS, color Doppler, and tumor marker test showed optimal diagnostic value with a sensitivity of 90.63 %, specificity of 97.14 %, positive prediction of 93.94 %, negative prediction of 98.55 %, and Youden’s index of 94.02 %. The combination of TVS, color Doppler, and tumor marker test is of great diagnostic value, which should be widely used in clinical practice.
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Schmid, B. C., & Oehler, M. K. (2013). New perspectives in ovarian cancer treatment. Maturitas,. doi:10.1016/j.maturitas.2013.11.009.
Meinhold-Heerlein, I., & Hauptmann, S. (2013). The heterogeneity of ovarian cancer. Archives Gynecology Obstetrics,. doi:10.1007/s00404-013-3114-3.
Lopez, J., Banerjee, S., & Kaye, S. B. (2013). New developments in the treatment of ovarian cancer—future perspectives. Annals of Oncology, 24(Suppl 10), x69–x76.
Menon, U., Griffin, M., & Gentry-Maharaj, A. (2013). Ovarian cancer screening-current status, future directions. Gynecologic Oncology,. doi:10.1016/j.ygyno.2013.11.030.
Chen, J. T., Kc, Y., Chang, M., et al. (1998). Use of PAPNTET testing to relatuate preceeding negative cervical smears of woman with high grade squamous intraepithelial lesion and carcinoma. Acta Cytology, 42(snapplz), 466.
Ghasemi, N., Ghobadzadeh, S., Zahraei, M., et al. (2014). HE4 combined with CA125: Favorable screening tool for ovarian cancer. Medical Oncology, 31(1), 808.
Kondalsamy-Chennakesavan, S., Hackethal, A., Bowtell, D., et al. (2013). Differentiating stage 1 epithelial ovarian cancer from benign ovarian tumours using a combination of tumour markers HE4, CA125, and CEA and patient’s age. Gynecologic Oncology, 129(3), 467–471.
Mohebtash, M., Tsang, K. Y., Madan, R. A., et al. (2011). A pilot study of MUC-1/CEA/TRICOM poxviral-based vaccine in patients with metastatic breast and ovarian cancer. Clinical Cancer Research, 17(22), 7164–7173.
Isonishi, S., Ogura, A., Kiyokawa, T., et al. (2009). Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman. International Journal of Clinical Oncology, 14(1), 70–73.
Loh, A. H., Gee, K. W., & Chua, J. H. (2013). Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: not as good as we thought? Pediatric Surgery International, 29(7), 709–713.
Dilokthornsakul, P., Chaiyakunapruk, N., Termrungruanglert, W., et al. (2013). The effects of metformin on ovarian cancer: A systematic review. International Journal of Gynecological Cancer, 23(9), 1544–1551.
Trivers, K. F., Patterson, J. R., Roland, K. B., et al. (2013). Issues of ovarian cancer survivors in the USA: A literature review. Supportive Care in Cancer, 21(10), 2889–2898.
Roland, K. B., Rodriguez, J. L., Patterson, J. R., et al. (2013). A literature review of the social and psychological needs of ovarian cancer survivors. Psychooncology, 22(11), 2408–2418.
Vitale, S. G., Marilli, I., Lodato, M., et al. (2013). The role of cytoreductive surgery in advanced-stage ovarian cancer: A systematic review. Updates in Surgery, 65(4), 265–270.
Byun, J. M., Kim, Y. N., Jeong, D. H., et al. (2013). Three-dimensional transvaginal ultrasonography for locally advanced cervical cancer. International Journal of Gynecological Cancer, 23(8), 1459–1464.
van Nagell, J. J., & Hoff, J. T. (2013). Transvaginal ultrasonography in ovarian cancer screening: Current perspectives. International Journal of Womens Health, 6, 25–33.
Menon, U., Griffin, M., & Gentry-Maharaj, A. (2013). Ovarian cancer screening-current status, future directions. Gynecology Oncology,. doi:10.1016/j.ygyno.2013.11.030.
Goff, B. A., Lowe, K. A., Kane, J. C., et al. (2012). Symptom triggered screening for ovarian cancer: A pilot study of feasibility and acceptability. Gynecologic Oncology, 124(2), 230–235.
Hossain, F., Karim, M. N., Rahman, S. M., et al. (2010). Preoperative detection of ovarian cancer by color Doppler ultrasonography and CA 125. Bangladesh Medical Research Council Bulletin, 36(2), 68–73.
Guerriero, S., Alcazar, J. L., Pascual, M. A., et al. (2011). The diagnosis of ovarian cancer: Is color Doppler imaging reproducible and accurate in examiners with different degrees of experience? Journal of Womens Health (Larchmt), 20(2), 273–277.
Guerriero, S., Alcazar, J. L., Ajossa, S., et al. (2010). Transvaginal color Doppler imaging in the detection of ovarian cancer in a large study population. International Journal of Gynecological Cancer, 20(5), 781–786.
Muralidhar, G. G., & Barbolina, M. V. (2013). Chemokine receptors in epithelial ovarian cancer. International Journal of Molecular Sciences, 15(1), 361–376.
Shapira, I., Oswald, M., Lovecchio, J., et al. (2013). Circulating biomarkers for detection of ovarian cancer and predicting cancer outcomes. British Journal of Cancer,. doi:10.1038/bjc.2013.795.
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Zhang, F., Zhang, Zl. The Diagnostic Value of Transvaginal Sonograph (TVS), Color Doppler, and Serum Tumor Marker CA125, CEA, and AFP in Ovarian Cancer. Cell Biochem Biophys 72, 353–357 (2015). https://doi.org/10.1007/s12013-014-0463-x
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DOI: https://doi.org/10.1007/s12013-014-0463-x