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A Randomized Controlled Trial of Conventional Fraction and Late Course Accelerated Hyperfraction Three-Dimensional Conformal Radiotherapy for Esophageal Cancer

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Abstract

We compared the curative and side-effects in esophageal carcinoma treated by conventional fraction (CF) and late course accelerated hyperfraction (LCAF) three-dimensional conformal radiotherapy. Ninety-eight patients were randomly assigned to two different radiotherapy model groups. Fifty patients were treated using CF three-dimensional conformal radiotherapy at a total dose of 60–68 Gy; 2 Gy/F; 5 fractions/week (median 64 Gy), 48 patients were treated with LCAF (First CF-treated at the dose 40 Gy. Later, LCAF-treated 1.5 Gy/F; 2 fractions/day; 21–27 Gy; a total dose of 61–67 Gy; median 64 Gy). The data showed that the 1-, 2- and 3-year-survival rates in LCAF group were 79.2, 56.3, and 43.8%, compared to 74, 54, and 36% in CF group (P = 0.476). The 1-, 2- and 3-year-local control rates in LCAF group were 81.3, 62.5, and 50%, compared to 78, 58, and 42% in CF group (P = 0.454). In CF group, the incidence of radiation-induced esophagitis was lower than that in LCAF group (72 vs. 93.8%; P = 0.008) and there was no significant difference between rates of radiation-induced pneumonitis in CF and LCAF groups (10 vs. 6.25%; P = 0.498). It was concluded that the 1-, 2- and 3-year-local control and survival rates of esophageal carcinoma patients treated with LCAF were slightly better than CF radiotherapy; however, the radiation side-effects in LCAF group were greater than those in CF group.

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Acknowledgment

We thank Changzhou Natural Science Foundation for financial support.

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Authors and Affiliations

  1. Department of Radiation Oncology, Changzhou Tumor Hospital Soochow University, Changzhou, 213002, Jiangsu, China

    Jian-Hua Wang, Xu-Jing Lu, Jian Zhou & Feng Wang

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  1. Jian-Hua Wang
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  2. Xu-Jing Lu
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  3. Jian Zhou
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  4. Feng Wang
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Correspondence to Xu-Jing Lu.

Additional information

Lu Xu-Jing and Wang Jian-Hua contributed equally to this study as co-first authors.

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Wang, JH., Lu, XJ., Zhou, J. et al. A Randomized Controlled Trial of Conventional Fraction and Late Course Accelerated Hyperfraction Three-Dimensional Conformal Radiotherapy for Esophageal Cancer. Cell Biochem Biophys 62, 107–112 (2012). https://doi.org/10.1007/s12013-011-9267-4

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