Abstract
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is one of the most common and serious complications of ERCP, which has become a major concern for digestive endoscopists. In the present study, we examine whether pancreatic duct stenting can reduce the incidence of PEP. Forty patients who underwent an ERCP in our hospital were selected according to their risk factors for PEP. They were randomly divided into two groups: (1) 20 subjects received a pancreatic duct stenting after ERCP to prevent pancreatitis (stent group, S); and (2) the other 20 subjects did not receive pancreatic duct stenting after ERCP (non-stent group, NS). Urine and serum amylase, and serum lipase were determined after the operation; symptoms of abdominal pain were monitored; cost of hospitalization was evaluated for the comparison. The results show that (1) 18 cases developed PEP, and they were significantly less in S group than in NS group (4 vs. 14 cases; P < 0.01); (2) Serum amylase was significantly lower in S group than in NS group (197.8 ± 339.7 vs. 825.4 ± 1253.4 U/l, respectively; P < 0.05); (3) The intensity of abdominal pain was 3.4 ± 0.8 in S group, compared to 4.1 ± 1.2 in NS group; (4) Duration of pharmaceutical treatment was not significantly different between the two groups (4.2 ± 1.4 vs. 6.1 ± 2.3 days, in S and NS group, respectively); and (5) The total hospitalization cost was significantly less in S group (8928 ± 2635 RMB) than in NS group (11288 ± 4325 RMB; P < 0.05). It is concluded that pancreatic duct stenting can reduce the incidence of PEP, shorten the duration of hospitalization, and therefore, lessen patients’ financial burden. It is shown to be an effective way to prevent PEP.
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Abbreviations
- ERCP:
-
Post-endoscopic retrograde cholangiopancreatography
- NS:
-
Non-stent group
- PEP:
-
Post-ERCP pancreatitis
- S:
-
Stent group
- SD:
-
Standard deviation
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Acknowledgments
The authors thank Drs. Meng, Xue, and Chang for their contribution to the procedures and the clinical data collection. The authors also thank Teacher Zhang for the translation work and the Inner Mongolia Digestive Diseases Institute for its generous support. Teams from the Department of Interventional Radiology and the Department of Gastroenterology are also gratefully acknowledged for their collaboration. This study was supported by the Health Fund 2008 R 2001-34 from Baotou Science and Technology Bureau.
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Pan, XP., Dang, T., Meng, XM. et al. Clinical Study on the Prevention of Post-ERCP Pancreatitis by Pancreatic Duct Stenting. Cell Biochem Biophys 61, 473–479 (2011). https://doi.org/10.1007/s12013-011-9230-4
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DOI: https://doi.org/10.1007/s12013-011-9230-4