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Therapeutic Sesamol Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Rats by Inhibiting Matrix Metalloproteinase-9

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Abstract

We investigated the therapeutic effect of sesamol against monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats. Male Sprague–Dawley rats were gavaged with a single dose of monocrotaline (90 mg/kg) to induce SOS. Sesamol (5, 10, 20, and 40 mg/kg) was subcutaneously injected 24 h after monocrotaline treatment. Control rats were given saline only. Aspartate transaminase, alanine transaminase, mast cells, CD 68+ Kupffer cells, neutrophils, myeloperoxidase, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), laminin, and collagen were assessed 48 h after monocrotaline treatment. All tested parameters, except for TIMP-1, laminin, and collagen, were significantly higher in monocrotaline-treated rats than in control rats, and, except for TIMP-1, laminin, and collagen, significantly lower in sesamol-treated rats than in monocrotaline-treated rats. In addition, liver pathology revealed that sesamol offered significant protection against SOS. We conclude that a single dose of sesamol therapeutically attenuated SOS by decreasing the recruitment of inflammatory cells, downregulating MMP-9, and upregulating TIMP-1 expression.

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Acknowledgment

This research was supported by grants NSC 99-2314-B-006-031-MY3 and NSC 99-2221-E-006-064-MY3 from the Taiwan National Science Council.

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Authors and Affiliations

  1. Department of Environmental and Occupational Health, National Cheng Kung University Medical College, 138 Sheng-Li Road, Tainan, 70428, Taiwan

    Srinivasan Periasamy, Dur-Zong Hsu, Shin-Yi Chen, Shan-Shan Yang, Victor Raj Mohan Chandrasekaran & Ming-Yie Liu

  2. Research Center for Environmental and Occupational Health and Preventive Medicine, National Cheng Kung University Medical College, Tainan, 70428, Taiwan

    Ming-Yie Liu

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  1. Srinivasan Periasamy
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  2. Dur-Zong Hsu
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  3. Shin-Yi Chen
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Correspondence to Ming-Yie Liu.

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Periasamy, S., Hsu, DZ., Chen, SY. et al. Therapeutic Sesamol Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Rats by Inhibiting Matrix Metalloproteinase-9. Cell Biochem Biophys 61, 327–336 (2011). https://doi.org/10.1007/s12013-011-9215-3

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