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Deleting islet autoimmunity

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Abstract

Even though there are numerous autoantigens for type 1 diabetes, current evidence suggests that a single autoantigen, namely insulin, is responsible for the key initiating event in autoimmunity. If a single autoantigen is necessary for triggering the autoimmune process, then antigen-specific therapy to block or delete the immune response against that autoantigen before epitope spreading occurs, may become a larger focus of future immunotherapeutic strategies. In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations.

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Acknowledgments

Research supported by NIH (R01 DK32083, DK32493, DK 55969, DK 06218, DK06405); Immune Tolerance Network (AI 15416); Diabetes Endocrine Research Center (DK 057516); Autoimmunity Prevention Center (AI 50864); and Clinical Research Centers Program (M01 RR00069, M01RR00051), American Diabetes Foundation, Juvenile Diabetes Foundation, and the Children’s Diabetes Foundation.

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Authors and Affiliations

  1. Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA

    Edwin Liu, Marcella Li, Jean Jasinski, Masakazu Kobayashi, Roberto Gianani, Maki Nakayama & George S. Eisenbarth

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  1. Edwin Liu
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  2. Marcella Li
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  3. Jean Jasinski
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  4. Masakazu Kobayashi
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  5. Roberto Gianani
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  6. Maki Nakayama
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  7. George S. Eisenbarth
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Correspondence to George S. Eisenbarth.

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Liu, E., Li, M., Jasinski, J. et al. Deleting islet autoimmunity. Cell Biochem Biophys 48, 177–182 (2007). https://doi.org/10.1007/s12013-007-0022-9

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