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The Adverse Cardiac Effects of Di(2-ethylhexyl)phthalate and Bisphenol A

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Abstract

The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous exposure to DEHP and BPA occurs through dietary intake, inhalation, dermal and intravenous exposure via consumer products and medical devices. This article reviews the literature examining the relationship between DEHP and BPA exposure and cardiac toxicity. In vitro and in vivo experimental reports are outlined, as well as epidemiological studies which examine the association between these chemicals and cardiovascular outcomes. Gaps in our current knowledge are also discussed, along with future investigative endeavors that may help resolve whether DEHP and/or BPA exposure has a negative impact on cardiovascular physiology.

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Abbreviations

BPA:

Bisphenol A

DEHP:

Di(2-ethylhexyl)phthalate

EDCs:

Endocrine-disrupting chemicals

MEHP:

Mono(2-ethylhexyl)phthalate

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Acknowledgments

The author thanks Dr. Narine Sarvazyan and Dr. Matthew Kay for helpful discussions. This work was supported by the National Institutes of Health (F32ES019057) and (K99ES023477).

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  1. Pharmacology and Physiology Department, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street NW, Washington, DC, 20052, USA

    Nikki Gillum Posnack

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Posnack, N.G. The Adverse Cardiac Effects of Di(2-ethylhexyl)phthalate and Bisphenol A. Cardiovasc Toxicol 14, 339–357 (2014). https://doi.org/10.1007/s12012-014-9258-y

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