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Anthracycline-induced phospholipase A2 inhibition

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Abstract

The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of the early culprits leading to anthracycline-induced cardiac dysfunction. The clinical importance and potential pharmaceutical use of this new phenomenon await further studies.

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Acknowledgments

The authors thank Dr. Ara Arutunyan for helpful discussions and the National Institutes of Health for the financial support.

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Authors and Affiliations

  1. Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC, 20037, USA

    Luther Swift & Narine Sarvazyan

  2. Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO, 63104, USA

    Jane McHowat

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  1. Luther Swift
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  2. Jane McHowat
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  3. Narine Sarvazyan
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Correspondence to Narine Sarvazyan.

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Swift, L., McHowat, J. & Sarvazyan, N. Anthracycline-induced phospholipase A2 inhibition. Cardiovasc Toxicol 7, 86–91 (2007). https://doi.org/10.1007/s12012-007-0012-6

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