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Higher Levels of Blood Selenium are Associated with Higher Levels of Serum Lipid Profile in US Adults with CKD: Results from NHANES 2013–2018

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Abstract

The association between selenium (Se) and lipid profile has been controversial in different populations, and the aim of the study was to investigate the relationship between Se and lipid profile in patients with chronic kidney disease (CKD). A total of 861 US adult patients with CKD (male: female = 404:457) from the National Health and Nutrition Examination Survey database were enrolled in this cross-sectional study. We used smoothing spline plots and multivariate binary logistic regression analyses to elucidate the relationships between blood Se and lipid profile. Multivariate adjusted smoothing spline plots showed that higher levels of blood Se were associated with higher levels of serum remnant cholesterol (RC), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels. Threshold and saturation effects were also observed between serum RC, TC, TG, LDL-C, and blood Se. In multivariate binary logistic regression analyses, the fully adjusted model showed that as blood Se increases by every 1 µg/L, the OR of high RC, high TG and high LDL-C in patients was 1.012 (95% CI: 1.001, 1.023 P = 0.046), 1.011 (95% CI: 1.001, 1.021 P = 0.043) and 1.009 (95% CI: 1.003, 1.016 P = 0.012), respectively. Furthermore, stratified analyses showed that the associations between blood Se and high RC/high TG were significantly stronger in patients aged < 65 years. Higher levels of blood Se were associated with increased serum lipid profile levels and increased risk of high RC, high TC, high LDL-C, and low HDL-C dyslipidemia in adult patients with CKD in the US. However, the real associations between blood Se and lipid profiles in this population should be verified in future prospective and randomized trials.

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Data Availability

The datasets generated during and/or analyzed during the current study are available at NHANES website, https://www.cdc.

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Acknowledgements

We thank the NHANES participants and staff for their contributions of the data and data collection.

Funding

This work was supported by the Guangzhou Municipal Health Commission under Grant 20221A011018.

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  1. Ziyuan Li and Jiahui Lai contributed equally to this work.

Authors and Affiliations

  1. Department of Nephrology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China

    Ziyuan Li, Qiongmei Chen, Xiaoshi Zhong, Yun Liu & Yan Liu

  2. Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen-University, Guangzhou, China

    Jiahui Lai

  3. Institute of Disease-Oriented Nutritional Research, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China

    Luona Wen, Rongshao Tan, Yun Liu & Yan Liu

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  1. Ziyuan Li
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Contributions

Ziyuan Li: Conceptualization, Methodology, Investigation, Data curation, Writing original draft; Jiahui Lai: Conceptualization, Software, Investigation, Writing – review & editing; Luona Wen: Investigation, Data curation; Qiongmei Chen:Investigation, Data curation; Rongshao Tan: Investigation, Writing–review & editing, Supervision; Xiaoshi Zhong: Investigation, Writing – review & editing, Supervision; Yun Liu: Methodology, Formal analysis, Project administration, Writing – review&editing, Supervision, Funding acquisition;Yan Liu: Conceptualization, Methodology, Formal analysis, Project administration, Writing – review & editing, Supervision.

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Correspondence to Yun Liu or Yan Liu.

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Study protocols for NHANES were approved by the NCHS ethnics review board (Protocol #2011–17, https://www.cdc.gov/nchs/nhanes/irba98.htm). All the participants signed the informed consent before participating in the study.

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Li, Z., Lai, J., Wen, L. et al. Higher Levels of Blood Selenium are Associated with Higher Levels of Serum Lipid Profile in US Adults with CKD: Results from NHANES 2013–2018. Biol Trace Elem Res 201, 5501–5511 (2023). https://doi.org/10.1007/s12011-023-03608-0

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