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Association of Urinary Zinc Concentrations with Dyslipidemia and Its Subtypes: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

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Abstract

This study elucidates the association between urinary zinc concentration and the risk of developing dyslipidemia and its subtypes in China’s ethnic minority residents. Based on the baseline survey data of the Chinese Multi-Ethnic Cohort (CMEC) study, 10,620 subjects were included in the study. Logistic regression analysis evaluated the relationship between urinary zinc concentration and dyslipidemia and its subtypes. After adjustment, compared with urinary zinc concentration quartile 1 (Q1), the odds ratios (ORs) and 95% confidence intervals (95% CIs) of dyslipidemia participants in the quartile 2 (Q2), quartile 3 (Q3), and quartile 4 (Q4) groups were 1.091 (0.963, 1.237), 1.151 (1.051, 1.304), and 1.393 (1.230, 1.579), respectively (P for trend < 0.001). While that of hypertriglyceridemia participants in the Q2, Q3, and Q4 groups were 1.130 (0.979, 1.306), 1.283 (1.113, 1.480), and 1.483 (1.287, 1.709), respectively (P for trend < 0.001). Lastly, the ORs and 95% CIs of hyperbetalipoproteinemia participants in the Q2, Q3, and Q4 groups were 1.166 (0.945, 1.439), 1.238 (1.007, 1.522), and 1.381 (1.126, 1.695), respectively (P for trend < 0.002). This study found that urinary zinc concentrations were not associated with hypercholesterolemia and hypoalphalipoproteinemia. The dose–response relationship was non-linear between urinary zinc concentration and dyslipidemia, hypertriglyceridemia and hyperbetalipoproteinemia (P for trend < 0.001). In the stratified analysis, urinary zinc levels were positively associated with the risk of dyslipidemia, hypertriglyceridemia, and hyperbetalipoproteinemia in male, ≥ 60 years old, Miao nationality, hypertension, diabetes, and BMI ≥ 24.0 kg/m2 subgroups. Our study provides some possible evidence that elevated urinary zinc concentrations are associated with an increased risk of dyslipidemia, hypertriglyceridemia, hyperbetalipoproteinemia.

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Data Availability

The data of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The investigators are grateful to the dedicated participants and all research staff of the study.

Funding

This research was supported by the National Natural Science Foundation of China (No. 82173566) and the National Key R&D Program of China (NO.2017YFC0907301).

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Authors and Affiliations

  1. School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, China

    Jianqin Zhong, Leilei Liu, Linyuan Zhang, Zixuan Xu, Lian Peng, Xiaolan Zhao, Qianyuan Yang, Tingting Yang & Feng Hong

  2. Guiyang Center for Disease Control and Prevention, Guiyang, 550003, China

    Degan Xu

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Contributions

Conceptualization, JZ; methodology, JZ and QY; investigation, LP and XZ; experiments, LZ and ZX; statistical analysis JZ, LL, and DX; writing original draft preparation, JZ; writing—review and editing, JZ, LL, and FH; administration, FH and TY; all authors have read and agreed to the published version of the manuscript.

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Correspondence to Feng Hong.

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This study was conducted in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of Sichuan University (K2016038) and the Ethics Committee of The Affiliated Hospital of Guizhou Medical University (2018[094]). Informed consent was obtained from all subjects involved in the study.

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Zhong, J., Liu, L., Zhang, L. et al. Association of Urinary Zinc Concentrations with Dyslipidemia and Its Subtypes: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study. Biol Trace Elem Res 201, 3592–3602 (2023). https://doi.org/10.1007/s12011-022-03454-6

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