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A Spatial Ecological Study on Hair Selenium Level of Residents in Keshan Disease Endemic and Non-endemic Areas in Heilongjiang Province, China

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Abstract

This study was aimed to provide, by mapping the spatial distribution of hair selenium levels of residents, visualized evidence for assessment of KD elimination from a perspective of selenium nutrition of the residents living in the KD-endemic and non-endemic areas. Using a spatial ecological research design, 401 male permanent residents in KD-endemic and non-endemic areas participated in this study. Demographic information and hair samples were obtained through a questionnaire survey and sample collection, respectively. Hair selenium was measured using hydride generation atomic fluorescence spectrometry. Thematic maps were created, and spatial analysis was conducted using ArcGIS 9.0. The median of hair selenium of the participants was 0.30 (IQR, 0.23-0.34) mg/kg. The median hair selenium of the residents in the KD-endemic areas was significantly lower than that of the residents of the non-endemic areas. The hair selenium levels of residents were spatially clustered, with cold spots and hot spots located in northwest and southwest regions respectively. Residents living in KD-endemic areas may still have selenium deficiency. Measuring hair selenium levels of residents in KD-endemic areas as a molecular marker of selenium nutritional status as part of KD surveillance could provide visualized evidence for the evaluation of KD elimination from a perspective of selenium nutrition of the residents living in the KD endemic areas.

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Funding

This study was funded by the National Natural Science Foundation of China (no. 81773368).

Author information

Author notes

  1. Shan Han

    Present address: Infectious Disease Hospital of Heilongjiang Province, Harbin, China

  2. Huihui Zhou

    Present address: Jining Medical University, Jining, China

  3. Xiao Zhang

    Present address: Qingdao Municipal Hospital, Qingdao, China

  4. Hong Liang, Yuehui Jia & Lei Qi

    Present address: Qiqihar Medical University, Qiqihar, China

  5. Yuanjie Zou and Xu Liu contributed equally to this work.

Authors and Affiliations

  1. Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China

    Yuanjie Zou, Xu Liu, Tong Wang, Yanan Wang, Shan Han, Yiyi Zhang, Shengqi Su, Huihui Zhou, Xiao Zhang, Hong Liang, Yuehui Jia, Lei Qi, Yuanyuan Wang & Ruixiang Wang

Authors
  1. Yuanjie Zou
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  2. Xu Liu
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  3. Tong Wang
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Contributions

Designed the research, TW; Conducted the research and collected the data, XL, YW, SH, YYZ, SS, HZ, XZ, HL, YJ, LQ, YW and RW; Analyzed the data, YZ and XL; Thematic map production, YZ and XL; Wrote the manuscript, TW and YZ. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Tong Wang.

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The authors declare that they have no conflict of interest.

Ethics Approval

The research protocol was approved by the review committee of the Ethics Committee of Harbin Medical University.

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All participants provided written informed consent.

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Cite this article

Zou, Y., Liu, X., Wang, T. et al. A Spatial Ecological Study on Hair Selenium Level of Residents in Keshan Disease Endemic and Non-endemic Areas in Heilongjiang Province, China. Biol Trace Elem Res 199, 4546–4554 (2021). https://doi.org/10.1007/s12011-021-02609-1

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