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Effects of Selenium on the Immunotoxicity of Subacute Arsenic Poisoning in Chickens

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Abstract

This study aimed to determine the effects of selenium on the immune toxicity of subacute arsenic poisoning in chickens. Two hundred 8-day-old broilers were randomly divided into 5 groups: the control group (0.1 mg/kg As + 0.2 mg/kg Se), the As group (3 mg/kg As + 0.2 mg/kg Se), As + Se group I (3 mg/kg As + 5 mg/kg Se), As + Se group II (3 mg/kg As + 10 mg/kg Se), and As + Se group III (3 mg/kg As + 15 mg/kg Se). The conclusions were drawn based on the following measurements: 3.0 mg/kg added to feed led to a decrease in the growth performance of the broilers, reduced the level and conversion rate of ANAE, reduced the blood protein content of the broilers but had no effect on the albumin/globulin ratio, and had an inhibitory effect on erythrocyte immunity. Selenium-added of 5 and 10 mg/kg in daily feed leads to increased growth performance, increases the positive rate and conversion rate of ANAE, increases the hemoglobin content of broilers, and promotes erythrocyte immunity, which indicates that the selenium-added reduces the toxic effects of arsenic; 3.0 mg/kg arsenic with 15 mg/kg selenium had the most severe toxic effects. Fifteen milligrams per kilogram of selenium added in daily feed increases the toxicity of arsenic to broilers. The dose of 10 mg/kg selenium showed the best inhibitory effect on subacute arsenic poisoning in the broilers.

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Funding

This manuscript was supported by the Visiting Scholar Program sponsored by the China Scholarship Council (201906915019).

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Author notes

  1. Zhihua Ren and Qiang Wu contributed equally to this work and should be considered co-first authors

Authors and Affiliations

  1. College of Veterinary Medicine, Sichuan Agricultural University, Ya’an, 625014, China

    Zhihua Ren, Huidan Deng, Yueru Yu, Youtian Deng, Ling Zhu, Ya Wang & Junliang Deng

  2. Leshan City, Shizhong District of Animal Husbandry Bureau, Leshan, 614000, China

    Qiang Wu & Wenjiao Tang

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  1. Zhihua Ren
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Submitted to Biological Trace Element Research in October 2020

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Ren, Z., Wu, Q., Deng, H. et al. Effects of Selenium on the Immunotoxicity of Subacute Arsenic Poisoning in Chickens. Biol Trace Elem Res 199, 4260–4272 (2021). https://doi.org/10.1007/s12011-020-02558-1

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