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Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?

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Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory condition that may emerge at a young age and often lasts for life. It often goes through phases of recurrence and remission and has a devastating effect on quality of life. The exact etiology of the disease is still unclear, but it appears that an inappropriate immune response to intestinal flora bacteria in people with a genetic predisposition may cause the disease. Managing inflammatory bowel disease is still a serious challenge. Oxidative stress and free radicals appear to be involved in the pathogenesis of this disease, and a number of studies have suggested the use of antioxidants as a therapeutic approach. The antioxidant and anti-inflammatory properties of some trace elements have led some of the research to focus on studying these trace elements in inflammatory bowel disease. Zinc and selenium are among the most important trace elements that have significant anti-inflammatory and antioxidant properties. Some studies have shown the importance of these trace elements in inflammatory bowel disease. In this review, we have attempted to provide a comprehensive overview of the findings of these studies and to gather current knowledge about the association of these trace elements with the inflammatory process and inflammatory bowel disease.

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Acknowledgments

We are very grateful to Prof. Gordon Ferns for his helpful comments.

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  1. Department of Clinical Biochemistry and Laboratory Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Mostafa Vaghari-Tabari, Davoud Jafari-Gharabaghlou, Fatemeh Sadeghsoltani & Parisa Hassanpour

  2. Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran

    Durdi Qujeq

  3. Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran

    Durdi Qujeq

  4. Connective Tissue Research Center, Tabriz University of Medical Science, Tabriz, Iran

    Nadereh Rashtchizadeh

  5. Biotechnology Research Center, Tabriz University of Medical Sciences, P.O. Box 14711, Tabriz, 5166614711, Iran

    Amir Ghorbanihaghjo

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Vaghari-Tabari, M., Jafari-Gharabaghlou, D., Sadeghsoltani, F. et al. Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?. Biol Trace Elem Res 199, 3190–3204 (2021). https://doi.org/10.1007/s12011-020-02444-w

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