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Oxidative Damage Induced by Nano-titanium Dioxide in Rats and Mice: a Systematic Review and Meta-analysis

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Abstract

Nano-titanium dioxide is a kind of widely used nanomaterial that exhibits various adverse outcomes. However, the role of oxidative stress in this regard remains controversial. This study aimed to evaluate whether oxidative stress is one of the toxicity mechanisms induced by nano-titanium dioxide in rats and mice model. In this meta-analysis, 64 relevant publications were included through detailed database search. The pooled results showed that nano-titanium dioxide exposure could promote the expression of oxidants, such as malonaldehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), superoxide anion (O2−), and hydrogen peroxide (H2O2). Meanwhile, the levels of antioxidant-related enzymes and molecules, such as superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT), were reduced. Subgroup analysis revealed that different intervention routes, exposure periods, exposure dosages, and sample sources could affect the oxidative stress when exposed to nano-titanium dioxide. It was worth noting that the levels of MDA, 8-OHdG, and GSH significantly increased (P < 0.05) when the particle size of nano-titanium dioxide was < 10 nm, whereas H2O2, SOD, and GPx showed the highest effect at 10–40 nm. This study indicated that nano-titanium dioxide could cause oxidative damage by affecting the levels of enzymes and molecules involved in oxidative stress in rats and mice. And these results could provide a reference for studies of the toxicity mechanism induced by nano-titanium dioxide in the future.

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References

  1. Wang Z, Zhang T, Huang F, Wang Z (2018) The reproductive and developmental toxicity of nanoparticles: a bibliometric analysis. Toxicol Ind Health 34(3):169–177. https://doi.org/10.1177/0748233717744430

    Article  CAS  PubMed  Google Scholar 

  2. Weir A, Westerhoff P, Fabricius L, Hristovski K, Goetz N (2012) Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46(4):2242–2250. https://doi.org/10.1021/es204168d

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Pugazhendhi A, Tnji E, Karuppusamy I, Kathirvel B (2018) Inorganic nanoparticles: a potential cancer therapy for human welfare. Int J Pharm 539(1-2):1–29. https://doi.org/10.1016/j.ijpharm.2018.01.034

    Article  CAS  Google Scholar 

  4. Chen X, Mao SS (2007) Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Chem Rev 107(7):2891–2959. https://doi.org/10.1021/cr0500535

    Article  CAS  PubMed  Google Scholar 

  5. Kumar PSM, Ponnusamy VK, Deepthi KR (2018) Controlled synthesis of Pt nanoparticle supported TiO2 nanorods as efficient and stable electrocatalysts for the oxygen reduction reaction. J Mater Chem A 6(46):23435–23444

    Article  Google Scholar 

  6. Shakeel M, Jabeen F, Qureshi NA, Fakhr EAM (2016) Toxic effects of titanium dioxide nanoparticles and titanium dioxide bulk salt in the liver and blood of male Sprague-Dawley rats assessed by different assays. Biol Trace Elem Res 173(2):405–426. https://doi.org/10.1007/s12011-016-0677-4

    Article  CAS  PubMed  Google Scholar 

  7. Shrivastava R, Raza S, Yadav A, Kushwaha P, Flora SJ (2014) Effects of sub-acute exposure to TiO2, ZnO and Al2O3 nanoparticles on oxidative stress and histological changes in mouse liver and brain. Drug Chem Toxicol 37(3):336–347. https://doi.org/10.3109/01480545.2013.866134

    Article  CAS  PubMed  Google Scholar 

  8. Li YS, Ootsuyama Y, Kawasaki Y, Morimoto Y, Higashi T, Kawai K (2018) Oxidative DNA damage in the rat lung induced by intratracheal instillation and inhalation of nanoparticles. J Clin Biochem Nutr 62(3):238–241. https://doi.org/10.3164/jcbn.17-70

    Article  CAS  Google Scholar 

  9. Valberg PA, Bruch J, Mccunney RJ (2009) Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk? Regul Toxicol Pharm 54(1):72–83. https://doi.org/10.1016/j.yrtph.2009.02.008

    Article  CAS  Google Scholar 

  10. Glass DC, Mazhar M, Xiang S, Dean P, Simpson P, Priestly B, Plebanski M, Abramson M, Sim MR, Dennekamp M (2017) Immunological effects among workers who handle engineered nanoparticles. Occup Environ Med 74(12):868–876. https://doi.org/10.1136/oemed-2016-104111

    Article  PubMed  Google Scholar 

  11. Rollerova E, Tulinska J, Liskova A, Kuricova M, Kovriznych J, Mlynarcikova A, Kiss A, Scsukova S (2015) Titanium dioxide nanoparticles: some aspects of toxicity/focus on the development. Endocr Regul 49(2):97–112. https://doi.org/10.4149/endo_2015_02_97

    Article  CAS  PubMed  Google Scholar 

  12. Hongbo S, Magaye R, Castranova V, Jinshun Z (2013) Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10(1):15. https://doi.org/10.1186/1743-8977-10-15

    Article  CAS  Google Scholar 

  13. Zhang X, Li W, Yang Z (2015) Toxicology of nanosized titanium dioxide: an update. Arch Toxicol 89(12):2207–2217. https://doi.org/10.1007/s00204-015-1594-6

    Article  CAS  PubMed  Google Scholar 

  14. Chang X, Zhang Y, Tang M, Bei W (2013) Health effects of exposure to nano-TiO2: a meta-analysis of experimental studies. Nanoscale Research Letters 8(1):51–51. https://doi.org/10.1186/1556-276X-8-51

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. IARC (2006) Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide. IARC Monogr Eval Carcinog Risks Hum 86:1–294

    Google Scholar 

  16. Shahin NN, Mohamed MM (2017) Nano-sized titanium dioxide toxicity in rat prostate and testis: possible ameliorative effect of morin. Toxicol Appl Pharmacol 334:129–141. https://doi.org/10.1016/j.taap.2017.08.014

    Article  CAS  PubMed  Google Scholar 

  17. Cui YL (2012) Molecular mechanisms of liver injury of mice caused by exposure to titanium dioxide nanoparticles. Dissertation, University of Suzhou. 37-38.

  18. Sang XZ (2014) Molecular mechanisms of immune function impaired of mouse spleen following exposure to titanium dioxide nanoparticles. Dissertation, University of Suzhou.66-69.

  19. Liu HL (2011) The biotoxicity of three kinds of typical nanomaterials. Dissertation, Chinese academy of military medical sciences.50-61.

  20. Jia X, Wang S, Zhou L, Sun L (2017) The potential liver, brain, and embryo toxicity of titanium dioxide nanoparticles on mice. Nanoscale Res Lett 12(1):478. https://doi.org/10.1186/s11671-017-2242-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Meena R, Kumar S, Paulraj R (2015) Titanium oxide (TiO2) nanoparticles in induction of apoptosis and inflammatory response in brain. J Nanopart Res 17(491). doi: https://doi.org/10.1007/s11051-015-2868-x

  22. Liang G, Pu Y, Yin L, Liu R, Ye B, Su Y, Li Y (2009) Influence of different sizes of titanium dioxide nanoparticles on hepatic and renal functions in rats with correlation to oxidative stress. J Toxicol Env Heal A 72(12):740–745. https://doi.org/10.1080/15287390902841516

    Article  CAS  Google Scholar 

  23. Abdou KH, Moselhy WA, Mohamed HM, El-Nahass ES, Khalifa AG (2019) Moringa oleifera leaves extract protects titanium dioxide nanoparticles-induced nephrotoxicity via Nrf2/HO-1 signaling and amelioration of oxidative stress. Biol Trace Elem Res 187(1):181–191. https://doi.org/10.1007/s12011-018-1366-2

    Article  CAS  PubMed  Google Scholar 

  24. Alidadi H, Khorsandi L, Shirani M (2018) Effects of quercetin on tubular cell apoptosis and kidney damage in rats induced by titanium dioxide nanoparticles. Malaysian Journal of Medical Sciences 25(2):2–81. https://doi.org/10.21315/mjms2018.25.2.8

    Article  Google Scholar 

  25. Al-Rasheed NM, Faddah LM, Mohamed AM, Abdel BN, Al-Rasheed NM, Mohammad RA (2013) Potential impact of quercetin and idebenone against immuno-inflammatory and oxidative renal damage induced in rats by titanium dioxide nanoparticles toxicity. J Oleo Sci 62(11):961–971

    Article  CAS  Google Scholar 

  26. Elnagar A, Ibrahim A, Soliman AM (2018) Histopathological effects of titanium dioxide nanoparticles and the possible protective role of N-acetylcysteine on the testes of male albino rats. Int J Fertil Steril 12(3):249–256. https://doi.org/10.22074/ijfs.2018.5389

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Attia HF, Soliman MM, Abdel-Rahman GH, Nassan MA, Ismail SA, Farouk M, Solcan C. (2013). Hepatoprotective effect of N-Acetylcystiene on the toxic hazards of titanium dioxide nanoparticles. Am J Pharmacol Toxicol 10(6). https://doi.org/10.3844/ajptsp.2013.141.147

    Article  CAS  Google Scholar 

  28. Canli EG, Atli G, Canli M (2017) Response of the antioxidant enzymes of the erythrocyte and alterations in the serum biomarkers in rats following oral administration of nanoparticles. Environ Toxicol Pharmacol 50:145–150. https://doi.org/10.1016/j.etap.2017.02.007

    Article  CAS  PubMed  Google Scholar 

  29. Chen AJ (2016) Central neurotoxicity through gustatory nerve pathway by instillation of ZnO and TiO2 nanoparticles. Dissertation, University of Southern Medical. 26-28.

  30. Chen Q, Zou H, Xing M (2012) Effects of different sized titanium dioxide nanoparticles on oxidative stress in rats. Zhejiang J Pre Med 24(11):1–3

    CAS  Google Scholar 

  31. Duan YM (2011) The molecular and immune mechanisms of the mouse liver and spleen damaged by exposure to nanoparticulate TiO2. Dissertation, University of Suzhou.36-41.

  32. El-Shenawy NS, Al-Harbi MS, Al HF (2016) Hormonal and organ-specific dysfunction induced by the interaction between titanium dioxide nanoparticles and salicylic acid in male mice. J Basic Clin Physiol Pharmacol 27(4):425–435. https://doi.org/10.1515/jbcpp-2015-0124

    Article  CAS  PubMed  Google Scholar 

  33. Zhiyi F, Yihe J, Bing L, Yinhua Z, Yixin M (2007) Study on the effect of nanosized and microsized titanium dioxide for spermatogenesis function of male rats. Pre Med Forum (02):137–140

  34. Fadda LM, Mohamed AM, Ali HM, Hagar H, Aldossari M (2018) Prophylactic administration of carnosine and melatonin abates the incidence of renal toxicity induced by an over dose of titanium dioxide nanoparticles. J Biochem Mol Toxicol 32(3):e22040. https://doi.org/10.1002/jbt.22040

    Article  CAS  PubMed  Google Scholar 

  35. Grissa I, Ezzi L, Chakroun S, Mabrouk A, Saleh AB, Braham H, Haouas Z, Cheikh HB (2017) Rosmarinus officinalis L. ameliorates titanium dioxide nanoparticles and induced some toxic effects in rats’ blood. Environ Sci Pollut Res Int 24(13):12474–12483. https://doi.org/10.1007/s11356-017-8848-1

    Article  CAS  PubMed  Google Scholar 

  36. Gui SX (2014) Molecular mechanisms of kidney injury following exposure to titanium dioxide nanoparticles in mice. Dissertation, University of Suzhou.45-47.

  37. Gao GD (2013) Nano-titanium dioxide exposure induced reproductive toxicity and alterations of gene expression in mice. Dissertation, University of Suzhou. 89

  38. Hassanein KM, El-Amir YO (2017) Protective effects of thymoquinone and avenanthramides on titanium dioxide nanoparticles induced toxicity in Sprague-Dawley rats. Pathol Res Pract 213(1):13–22. https://doi.org/10.1016/j.prp.2016.08.002

    Article  CAS  PubMed  Google Scholar 

  39. Hassanein K, El-Amir YO (2018) Ameliorative effects of thymoquinone on titanium dioxide nanoparticles induced acute toxicity in rats. Int J Vet Sci Med 6(1):16–21. https://doi.org/10.1016/j.ijvsm.2018.02.002

    Article  PubMed  PubMed Central  Google Scholar 

  40. Hu RP (2013) Molecular mechanisms of impairment of spatial recognition memory in mice following exposure to titanium dioxide nanoparticles. Dissertation, University of Suzhou.55

  41. Jafari A, Rasmi Y, Hajaghazadeh M, Karimipour M (2018) Hepatoprotective effect of thymol against subchronic toxicity of titanium dioxide nanoparticles: biochemical and histological evidences. Environ Toxicol Pharmacol 58:29–36. https://doi.org/10.1016/j.etap.2017.12.010

    Article  CAS  PubMed  Google Scholar 

  42. Jin YL, Yang M, Su SB, Chen JY, Liu M (2014) Protective effect of propolis on redox damage induced by nano-TiO2 in rats. Chin Occup Med 41(02):147–150

    CAS  Google Scholar 

  43. Khorsandi L, Orazizadeh M, Mansori E, Fakhredini F (2015) Glycyrrhizic acid attenuated lipid peroxidation induced by titanium dioxide nanoparticles in rat liver. Bratisl Lek Listy 116(6):383–388

    CAS  PubMed  Google Scholar 

  44. Khorsandi L, Orazizadeh M, Moradi-Gharibvand N, Hemadi M, Mansouri E (2017) Beneficial effects of quercetin on titanium dioxide nanoparticles induced spermatogenesis defects in mice. Environ Sci Pollut Res Int 24(6):5595–5606. https://doi.org/10.1007/s11356-016-8325-2

    Article  CAS  PubMed  Google Scholar 

  45. Li YW (2009) Studies on the acute hazards of different sized nano-titanium dioxide particles to mice. Dissertation, University of Hebei Medical. 27

  46. Caixia Yu (2018) Effects and mechanisms of lung injury induced by nitrogen-droped nano-titanium dioxide. Dissertation, University of Guizhou Medical. 28–29

  47. Lin L, Song GL, Zeng HM, Hongmei Z, Zhengzheng W, Longlong L, Lu S, Zhangrui X, Wei L (2017) Effect of nano titanium dioxide on the kidney female mouse. J Shihezi hihezi hihezi hihezi hihezi hihezi Univniv 35(03):344–348

  48. Liu HT (2014) Liver injury in mice caused by nano titanium dioxide and its molecular mechanism. Dissertation, University of Suzhou. 22-24.

  49. Liu LL, Song GL, Niu Q, Ruling M, Yusong D, Zhenzhen W, Hongmei Z, Lin L (2018) The study of the nephrotoxicity on male mice induced by Nano-TiO2. J Shihezi Univ 36(03):278–281

    Google Scholar 

  50. Liu ZM (2016) Research for the nervous system and cardiovascular system toxicity of nano-titanium dioxide. Dissertation, University of Central China normal. 22-24.

  51. Martins AJ, Azevedo LF, de Souza RC, Carneiro M, Venancio VP, Almeida MR, Antunes LMG, Carvalho HR, Rodrigues JL, Ogunjimi AT, Adeyemi JA, Barbosa FJ (2017) Evaluation of distribution, redox parameters, and genotoxicity in Wistar rats co-exposed to silver and titanium dioxide nanoparticles. J Toxicol Environ Health A 80(19-21):1156–1165. https://doi.org/10.1080/15287394.2017.1357376

    Article  CAS  PubMed  Google Scholar 

  52. Meena R, Kajal K, P R (2015) Cytotoxic and genotoxic effects of titanium dioxide nanoparticles in testicular cells of male Wistar rat. Appl Biochem Biotechnol 175(2):825–840. https://doi.org/10.1007/s12010-014-1299-y

    Article  CAS  PubMed  Google Scholar 

  53. Morgan A, Galal MK, Ogaly HA, Ibrahim MA, Abd-Elsalam RM, Noshy P (2017) Tiron ameliorates oxidative stress and inflammation in titanium dioxide nanoparticles induced nephrotoxicity of male rats. Biomed Pharmacother 93:779–787. https://doi.org/10.1016/j.biopha.2017.07.006

    Article  CAS  PubMed  Google Scholar 

  54. Morgan A, Ibrahim MA, Galal MK, Ogaly HA, Abd-Elsalam RM (2018) Innovative perception on using tiron to modulate the hepatotoxicity induced by titanium dioxide nanoparticles in male rats. Biomed Pharmacother 103:553–561. https://doi.org/10.1016/j.biopha.2018.04.064

    Article  CAS  PubMed  Google Scholar 

  55. Morgan AM, Ibrahim MA, Noshy PA (2017) Reproductive toxicity provoked by titanium dioxide nanoparticles and the ameliorative role of tiron in adult male rats. Biochem Biophys Res Commun 486(2):595–600. https://doi.org/10.1016/j.bbrc.2017.03.098

    Article  CAS  PubMed  Google Scholar 

  56. Niu LH, Dong HT, Yang LS, Bao S, Rong Z, Yujie N (2015) Effects of different particle sizes of nano-titanium dioxide on the antioxidant capacity of mice. J Hebei Med Univ 36(02):184–187

    CAS  Google Scholar 

  57. Rizk MZ, Ali SA, Hamed MA, El-Rigal NS, Aly HF, Salah HH (2017) Toxicity of titanium dioxide nanoparticles: effect of dose and time on biochemical disturbance, oxidative stress and genotoxicity in mice. Biomed Pharmacother 90:466–472. https://doi.org/10.1016/j.biopha.2017.03.089

    Article  CAS  PubMed  Google Scholar 

  58. Sheng L, Wang X, Sang X, Ze Y, Zhao X, Liu D, Gui S, Sun Q, Cheng J, Cheng Z, Hu R, Wang L, Hong F (2013) Cardiac oxidative damage in mice following exposure to nanoparticulate titanium dioxide. J Biomed Mater Res A 101(11):3238–3246. https://doi.org/10.1002/jbm.a.34634

    Article  CAS  PubMed  Google Scholar 

  59. Shukla RK, Kumar A, Vallabani NV, Pandey AK, Dhawan A (2014) Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice. Nanomedicine (Lond) 9(9):1423–1434. https://doi.org/10.2217/nnm.13.100

    Article  CAS  Google Scholar 

  60. Song G, Lin L, Liu L, Wang K, Ding Y, Niu Q, Mu L, Wang H, Shen H, Guo S (2017) Toxic effects of anatase titanium dioxide nanoparticles on spermatogenesis and testicles in male mice. Pol J Environ Stud 26(6):2739–2745. https://doi.org/10.15244/pjoes/70807

    Article  CAS  Google Scholar 

  61. Song MF, Wang YW, Wang C, Long Z, Kailiang P, Yayin L (2015) Oxidative DNA damage in liver of mice induced by titanium dioxide nanoparticles. J Environ Occup Med 32(04):358–361

    CAS  Google Scholar 

  62. Sun QQ (2014) Long-term exposure to titanium dioxide nanoparticles induced pulmonary toxicity in mice and its molecular mechanisms. Dissertation, University of Suzhou. 28-29.

  63. Sun Q, Tan D, Ze Y, Sang X, Liu X, Gui S, Cheng Z, Cheng J, Hu R, Gao G, Liu G, Zhu M, Zhao X, Sheng L, Wang L, Tang M, Hong F (2012) Pulmotoxicological effects caused by long-term titanium dioxide nanoparticles exposure in mice. J Hazard Mater 235:47–53. https://doi.org/10.1016/j.jhazmat.2012.05.072

    Article  CAS  PubMed  Google Scholar 

  64. Sun Q, Tan D, Zhou Q, Liu X, Cheng Z, Liu G, Zhu M, Sang X, Gui S, Cheng J, Hu R, Tang M, Hong F (2012) Oxidative damage of lung and its protective mechanism in mice caused by long-term exposure to titanium dioxide nanoparticles. J Biomed Mater Res A 100A(10):2554–2562. https://doi.org/10.1002/jbm.a.34190

    Article  CAS  Google Scholar 

  65. Tian JZ, Guo HC, Yue XL, Yi L, Yue Z, Weiyi W, Yaning W, Rong Z, Yujie N (2014) Protection of vitamin C on the cardiac injury induced by nano-titanium dioxide in mice. Chin J Pharmacol Toxicol 28(02):227–232

    CAS  Google Scholar 

  66. Wang S (2009) Target organs selectivity induced by intratracheally instilling titanium dioxide nanoparticles in rats. Dissertation, University of Southeast. 14-15.

  67. Wang WB, Li CL, An LH, Zang FM, Lihua Y, Hua Y, Meng E, Huinan Z, Jie L (2013) Effects of nano-TiO2 exposure on oxidative stress and hippocampus structure in rats. J Environ Health 30(12):1054–1057

    CAS  Google Scholar 

  68. Wang WB (2014) Effect of nano-titanium dioxide on the central nervous system in rat and the mechanism. Dissertation, University of Shandong.24-33.

  69. Wang J, Chen C, Liu Y, Jiao F, Li W, Lao F, Li Y, Li B, Ge C, Zhou G, Gao Y, Zhao Y, Chai Z (2008) Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases. Toxicol Lett 183(1-3):72–80. https://doi.org/10.1016/j.toxlet.2008.10.001

    Article  CAS  PubMed  Google Scholar 

  70. Wang Y, Chen Z, Ba T, Pu J, Chen T, Song Y, Gu Y, Qian Q, Xu Y, Xiang K, Wang H, Jia G (2013) Susceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticles. Small 9(9-10SI):1742–1752. https://doi.org/10.1002/smll.201201185

    Article  CAS  PubMed  Google Scholar 

  71. Wang Y, Chen ZJ, Ba T, Ji P, Xiaoxing C, Guang J (2014) Effects of TiO2 nanoparticles on antioxidant function and element content of liver and kidney tissues in young and adult rats. J Peking Univ 46(3):395–399. https://doi.org/10.3969/j.issn.1671-167X.2014.03.011

    Article  CAS  Google Scholar 

  72. Chang XH, Chen LS, Yang T, Meng T, Bei W (2014) Experimental study on subacute pulmonary toxicity induced by intra-tracheal instillation of nano-TiO2 in rats. J Southeast Univ (3):616–620. https://doi.org/10.3969/j.issn.1001-0505.2014.03.029

  73. Yu X, Zhao X, Ze Y, Wang L, Liu D, Hong J, Xu B, Lin A, Zhang C, Zhao Y, Li B, Hong F (2014) Changes of serum parameters of TiO2 nanoparticle-induced atherosclerosis in mice. J Hazard Mater 280:364–371. https://doi.org/10.1016/j.jhazmat.2014.08.015

    Article  CAS  PubMed  Google Scholar 

  74. Zhang T, Tang M, Wang S, Yang Y, Mingyu L, Bing Y (2008) Effects of lung perfusion with nano-titanium dioxide particles on the oxidative damage of rat viscera. Acta Sci Natu Univ Nankaiensis (03):24–28

  75. Zhang WJ (2009) Study on toxicological and biological activity of nano-TiO2. Dissertation, Tianjin University of Technology. 13-14.

  76. Zhao XY (2013) Effects of different sized nano-titanium dioxide particles on the oxidative stress and DNA damage in rats after intratracheal administration. Dissertation, University of Hebei Medical.33-36.

  77. Zhao J, Li N, Wang S, Zhao X, Wang J, Yan J, Ruan J, Wang H, Hong F (2010) The mechanism of oxidative damage in the nephrotoxicity of mice caused by nano-anatase TiO2. J Exp Nanosci 5(5):447–462. https://doi.org/10.1080/17458081003628931

    Article  CAS  Google Scholar 

  78. Zhu Y (2015) Effect of Foxo3a on DNA damage induced by nanoparticle titanium dioxide by intratracheal administration in rat. Dissertation, University of Hebei medical.39-41.

  79. Tripathi VK, Sivakumar AS, Dhasmana A, Hwang I (2018) Crosstalk between co-cultured 3T3-L1 and C2C12 cells after the exposure of nano-titanium dioxide. J Nanosci Nanotechnol 18(6):3870–3879. https://doi.org/10.1166/jnn.2018.15184

    Article  CAS  Google Scholar 

  80. Ghanbary F, Seydi E, Naserzadeh P, Salimi A (2017) Toxicity of nano-titanium dioxide (TiO2-NP) on human monocytes and their mitochondria. Environ Sci Pollut R 25(7):6739–6750. https://doi.org/10.1007/s11356-017-0974-2

    Article  CAS  Google Scholar 

  81. Hong F, Yu X, Wu N, Zhang YQ (2017) Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles. Toxicol Res (Camb) 6(2):115–133. https://doi.org/10.1039/c6tx00338a

    Article  CAS  Google Scholar 

  82. Wu T, Tang M (2018) Review of the effects of manufactured nanoparticles on mammalian target organs. J Appl Toxicol 38(1):25–40. https://doi.org/10.1002/jat.3499

    Article  CAS  PubMed  Google Scholar 

  83. Vasantharaja D, Ramalingam V, Reddy GA (2015) Oral toxic exposure of titanium dioxide nanoparticles on serum biochemical changes in adult male Wistar rats. Int J Nanomedicine 2(1):46–53

    CAS  Google Scholar 

  84. Alarifi S, Ali D, Al-Doaiss AA, Ali BA, Ahmed M, Al-Khedhairy AA (2013) Histologic and apoptotic changes induced by titanium dioxide nanoparticles in the livers of rats. Int J Nanomedicine 8:3937–3943. https://doi.org/10.2147/IJN.S47174

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Chang X, Zhang Y, Tang M, Wang B (2013) Health effects of exposure to nano-TiO2: a meta-analysis of experimental studies. Nanoscale Res Lett 8(1):51. https://doi.org/10.1186/1556-276X-8-51

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Funding

This work was financially supported by the National Natural Science Foundation of China (No. 81560536) and Shihezi University Science and Technology Research and Development Project (No. RCZX201331).

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  1. Department of Public Health, School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China

    Hongmei An, Chunmei Ling, Mengchuan Xu, Mingjuan Hu, Haixia Wang, Jiaqing Liu, Guangling Song & Jiaming Liu

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An, H., Ling, C., Xu, M. et al. Oxidative Damage Induced by Nano-titanium Dioxide in Rats and Mice: a Systematic Review and Meta-analysis. Biol Trace Elem Res 194, 184–202 (2020). https://doi.org/10.1007/s12011-019-01761-z

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