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Aluminum Chloride Causes the Dysfunction of Testes Through Inhibiting the ATPase Enzyme Activities and Gonadotropin Receptor Expression in Rats

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Abstract

The aim of this experiment is to explore the effects of aluminum chloride (AlCl3) on the ATPase enzymes and gonadotropin receptors in the testes. Eighty male Wistar rats were orally exposed to 0 mg/kg body weight (BW) (control group, CG), 64 mg/kg BW (low-dose group, LG), 128 mg/kg BW (mid-dose group, MG), or 256 mg/kg BW (high-dose group, HG) for 120 days. The microstructure and ultrastructure of testes; the activities of Na+-K+-ATPase, Mg2+-ATPase, and Ca2+-ATPase; and the mRNA and protein expressions of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptors (LHR) in the testes were examined. The results showed that the testes histological structure were damaged; the activities of Na+-K+-ATPase, Mg2+-ATPase, and Ca2+-ATPase, the mRNA and protein expressions of FSHR and LHR in the testes were all decreased in the rats with AlCl3 exposure. It indicates that AlCl3 causes the dysfunction of testes in rats.

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Acknowledgements

This study was supported by a grant from the Natural Science Foundation of Heilongjiang Province (C201425).

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Author notes

  1. Xudong Sun and Hao Sun contributed equally to this study.

Authors and Affiliations

  1. Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin, 150030, China

    Xudong Sun, Kaiyuan Yu, Yanfen Liu, Kexiang Liu & Yanfei Li

  2. Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, 5333 Xi’an Road, Changchun, Jilin, 130062, China

    Xudong Sun

  3. Laishan District Bureau of Commerce of Yantai city, Yantan, Shandong Province, 264003, China

    Hao Sun

  4. Vascular Surgery Department, The First hospital of Jilin University, Changchun, 130021, China

    Zhongying Wang

  5. Institute of Special Animal and Plant Sciences of Chinese Academy of Agricultural Sciences, Changchun, 130112, China

    Yanzhu Zhu

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  1. Xudong Sun
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  2. Hao Sun
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  3. Kaiyuan Yu
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  8. Yanfei Li
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Correspondence to Yanfei Li.

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The experimental protocol was approved by the Ethics Committee on the Use and Care of Animals, Northeast Agricultural University, China.

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The authors declare that they have no conflict of interest.

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Sun, X., Sun, H., Yu, K. et al. Aluminum Chloride Causes the Dysfunction of Testes Through Inhibiting the ATPase Enzyme Activities and Gonadotropin Receptor Expression in Rats. Biol Trace Elem Res 183, 296–304 (2018). https://doi.org/10.1007/s12011-017-1120-1

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  • DOI: https://doi.org/10.1007/s12011-017-1120-1

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