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Effects of Electromagnetic Pulse on Serum Element Levels in Rat

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Abstract

Electromagnetic pulse (EMP) was a potentially harmful factor to the human body, and a biological dosimetry to evaluate effects of EMP is necessary. Little is known about effects of EMP on concentration of macro and trace elements in serum so far. In this study, Sprague-Dawley rats were randomly divided into 50-kV/m EMP-exposed group (n = 10), 100-kV/m EMP-exposed group (n = 10), 200-kV/m EMP-exposed group (n = 40), and the sham-exposed group (n = 20). The macro and trace element concentrations in serum were examined at 6, 12, 24, and 48 h after EMP exposure at different electric field intensities. Compared with the sham-exposed groups, the concentration of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), selenium (Se), and manganese (Mn) in rat serum was not changed significantly within 48 h after 200 pulses of EMP exposure at electric field intensity of 50, 100, and 200 kV/m although the K level was decreased and the Ca level was increased with the electric field intensity of EMP increasing. In addition, there was a tendency that the Zn level was decreased with the time going on within 48 h after EMP exposure. Under our experimental conditions, EMP exposure cannot affect the concentration of macro and trace elements in rat serum. There was no time–effect or dose–effect relationship between EMP exposure and serum element levels. The macro and trace elements in serum are not suitable endpoints of biological dosimetry of EMP.

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Abbreviations

EMP:

Electromagnetic pulse

Na:

Sodium

K:

Potassium

Mg:

Magnesium

Ca:

Calcium

Zn:

Zinc

Cu:

Copper

Fe:

Iron

Se:

Selenium

Mn:

Manganese

GTEM:

Gigahertz transverse electromagnetic

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Acknowledgement

This study was supported by the National Natural Science Foundation of China (No. 30800928).

Conflict of Interest

The authors indicate no potential conflicts of interest.

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Authors and Affiliations

  1. Department of Radiation Medicine and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi’an, 710032, Shaanxi, People’s Republic of China

    Kangchu Li, Dongqing Ren, Yurong Li, Guirong Ding, Junye Liu, Yao Guo & Guozhen Guo

  2. Department of Pathology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, 710032, Shaanxi, People’s Republic of China

    Shirong Ma

Authors
  1. Kangchu Li
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  2. Shirong Ma
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  3. Dongqing Ren
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  4. Yurong Li
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  5. Guirong Ding
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  6. Junye Liu
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  7. Yao Guo
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  8. Guozhen Guo
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Corresponding author

Correspondence to Guozhen Guo.

Additional information

Kangchu Li and Shirong Ma contributed equally to this work.

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Li, K., Ma, S., Ren, D. et al. Effects of Electromagnetic Pulse on Serum Element Levels in Rat. Biol Trace Elem Res 158, 81–86 (2014). https://doi.org/10.1007/s12011-014-9903-0

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  • DOI: https://doi.org/10.1007/s12011-014-9903-0

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