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Hepatoprotective Effect of Arctium lappa Root Extract on Cadmium Toxicity in Adult Wistar Rats

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An Erratum to this article was published on 24 July 2014

Abstract

This study was performed to determine the effects of Arctium lappa (Al) to protect against cadmium damage in the rat liver. Male rats received a single i.p. dose of CdCl2 (1.2 mg/kg body weight (BW)) with or without Al extract administered daily by gavage (300 mg/kg BW) for 7 or 56 days. After 7 days, Al caused plasma transaminase activity to diminish in groups Al (glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT)) and CdAl (GPT). After 56 days, GOT and GPT plasma activities were reduced in the Cd group. No alteration in plasma levels of creatinine, total bilirubin, and total protein were observed. GOT liver activity increased in the Cd group. No alteration was observed in superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), and malondialdehyde (MDA) dosage. In the Cd group, hepatocyte proportion decreased and sinusoid capillary proportion increased. In the Al and CdAl groups, the nuclear proportion increased and the cytoplasmic proportion decreased. The hepatocyte nucleus density reduced in Cd and increased in the Al group. After 56 days, there was no alteration in the Cd group. In Al and CdAl groups, the nuclear proportion increased without cytoplasmic proportion variation, but the sinusoid capillary proportion was reduced. The hepatocyte nucleus density decreased in the Cd group and increased in the Al and CdAl groups. In conclusion, the liver function indicators showed that A. lappa protected the liver against cadmium toxicity damage.

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Acknowledgments

This work was supported by grants and scholarships from the Fundação de Amparo à Pesquisa do Estado de São Paulo (grant number 2006 ⁄06142-8).

Conflict of Interest

The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Departamento de Ciências Biológicas, Universidade Estadual do Paraná/Campus Paranaguá, Rua Comendador Correia Junior, 117—Centro, Paranaguá, Paraná, 83203-560, Brazil

    Fabricia de Souza Predes

  2. Departamento de Biologia Estrutural e Funcional, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil

    Maria Aparecida da Silva Diamante, Bread Cruz, Maria Cristina Cintra Gomes Marcondes & Heidi Dolder

  3. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrárias, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil

    Mary Ann Foglio

  4. Departamento de Bioquímica, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil

    Camila Almeida Camargo & Hiroshi Aoyama

  5. Universidade Paulista, Campinas, São Paulo, Brazil

    Silvio Cesar Miranda

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  1. Fabricia de Souza Predes
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  2. Maria Aparecida da Silva Diamante
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  3. Mary Ann Foglio
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  6. Silvio Cesar Miranda
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  7. Bread Cruz
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  8. Maria Cristina Cintra Gomes Marcondes
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  9. Heidi Dolder
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Correspondence to Fabricia de Souza Predes.

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de Souza Predes, F., da Silva Diamante, M.A., Foglio, M.A. et al. Hepatoprotective Effect of Arctium lappa Root Extract on Cadmium Toxicity in Adult Wistar Rats. Biol Trace Elem Res 160, 250–257 (2014). https://doi.org/10.1007/s12011-014-0040-6

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  • DOI: https://doi.org/10.1007/s12011-014-0040-6

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