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Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects

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A Correction to this article was published on 26 September 2018

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Abstract

Selenium is an essential nutrient for human health, and maternal selenium concentration has been reported to be associated with pregnancy outcome. To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case–control study to evaluate the correlations among selenium status, glutathione peroxidase activity, and spontaneous abortion. A total of 46 subjects with normal pregnancies and 25 subjects with spontaneous abortion were recruited, and their serum selenium concentrations and serum glutathione peroxidase activities were analyzed. The total serum selenium concentrations in subjects with normal pregnancies were significantly higher than those of subjects with spontaneous abortion; however, the glutathione peroxidase activities were similar in both groups. We further separated the subjects into smoking and nonsmoking groups, and the logistic regression analysis suggested that total serum selenium concentration, but not serum glutathione peroxidase activity or smoking, was significantly correlated with the incidence of miscarriage. The present study thus reaffirms that low serum selenium levels are associated with miscarriage and that selenium plays an important role in pregnancy maintenance.

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Change history

  • 26 September 2018

    The original version of this article unfortunately contained a mistake. The name of ���Herlambang herlambang��� is now corrected in the author group of this article.

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Authors and Affiliations

  1. Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km. 21, Jatinangor, 45363, Indonesia

    Rizky Abdulah, Irma M. Puspitasari & Melisa I. Barliana

  2. Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Japan

    Rizky Abdulah,  Mutakin, Irma R. Defi, Eka W. Suradji, Irma M. Puspitasari, Chiho Yamazaki, Minato Nakazawa & Hiroshi Koyama

  3. Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia

    Herlambang Noerjasin

  4. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia

    Leri Septiani

  5. Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia

    Mutakin

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  1. Rizky Abdulah
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Correspondence to Rizky Abdulah.

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Abdulah, R., Noerjasin, H., Septiani, L. et al. Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects. Biol Trace Elem Res 154, 1–6 (2013). https://doi.org/10.1007/s12011-013-9701-0

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  • DOI: https://doi.org/10.1007/s12011-013-9701-0

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