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Effects of Subchronic Aluminum Exposure on the Immune Function of Erythrocytes in Rats

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Abstract

This study assessed effects of aluminum (Al) exposure on the immune function of erythrocytes in rats. Forty male Wistar rats (5 weeks old) weighed 110–120 g were randomly allocated equally into four groups according to their weights and were orally exposed to 0, 64.18, 128.36, and 256.72 mg/kg body weight aluminum trichloride in drinking water for 120 days. Levels of erythrocytes C3b receptor rate (RBC-C3bRR), erythrocytes C3b immune complex rosette rate (RBC-ICR), erythrocytes rosette forming enhancing rate (ERER) and erythrocytes rosette forming inhibitory rate (ERIR) were determined by the end of experiment. The three Al-treated groups had lower values of RBC-C3bRR and ERER, and higher values of RBC-ICR and ERIR than those in control group. The levels of RBC-C3bRR and ERER decreased, while the levels of RBC-ICR and ERIR increased with the increases of Al content in drinking water. The results suggest that the immune function of erythrocytes in rats is suppressed by Al exposure.

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Acknowledgments

This study was supported by a grant from the Natural Science Fund of Heilongjiang Province of China (C200935).

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Authors and Affiliations

  1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China

    Yanzhu Zhu, Hansong Zhao, Xinwei Li, Lichao Zhang, Chongwei Hu, Bing Shao, Hao Sun, Alphajoh A. Bah, Yanfei Li & Zhigang Zhang

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  1. Yanzhu Zhu
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  2. Hansong Zhao
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  3. Xinwei Li
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  4. Lichao Zhang
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  5. Chongwei Hu
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  6. Bing Shao
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  7. Hao Sun
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  8. Alphajoh A. Bah
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  9. Yanfei Li
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  10. Zhigang Zhang
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Correspondence to Yanfei Li or Zhigang Zhang.

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Zhu, Y., Zhao, H., Li, X. et al. Effects of Subchronic Aluminum Exposure on the Immune Function of Erythrocytes in Rats. Biol Trace Elem Res 143, 1576–1580 (2011). https://doi.org/10.1007/s12011-011-8964-6

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  • DOI: https://doi.org/10.1007/s12011-011-8964-6

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