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Parameters of Metabolic Syndrome and Its Relationship with Zincemia and Activities of Superoxide Dismutase and Glutathione Peroxidase in Obese Women

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Abstract

Alterations in antioxidant defense in obese people with metabolic syndrome can contribute to oxidative stress. This study assessed the relationship between the parameters of metabolic syndrome and the zincemia, activity of superoxide dismutase, and glutathione peroxidase enzymes in obese women. Seventy-three premenopausal women, aged between 20 and 50 years, were divided into two groups: case group, composed of obese (n = 37), and control group, composed of no obese (n = 36). Analyses of zinc intake, parameters of metabolic syndrome, plasma, and erythrocyte zinc, and activities of superoxide dismutase and glutathione peroxidase were carried out. The mean values of body mass index of obese women and control group were 34.5 ± 3.4 and 21.7 ± 1.9 kg/m2, respectively (p < 0.05). In the study, body mass index, waist circumference, and zinc intake were higher in obese women than control group (p < 0.05). The plasma zinc and activity of superoxide dismutase did not show significant differences between obese and controls (p > 0.05). The values of erythrocyte zinc was 36.4 ± 15.0 μg/gHb and 45.4 ± 14.3 μg/gHb and of glutathione peroxidase was 46.4 ± 19.4 U/gHb and 36.7 ± 13.6 U/gHb in obese women and controls, respectively (p < 0.05). The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations in erythrocytes. Regression analysis demonstrates that the erythrocyte zinc and activity of superoxide dismutase enzyme is influenced by components of the metabolic syndrome, and the plasmatic glucose, body mass index, and waist circumference have a negative correlation with this enzyme.

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Acknowledgment

Dr. José Machado Moita Neto - Department of Chemistry, Federal University of Piauí for the work of statistical analysis.

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Authors and Affiliations

  1. Department of Nutrition, University Federal of Piauí (UFPI), Rua Hugo Napoleão no. 665 Ed. Palazzo Reale Apt. 2001 Jóquei, Teresina, PI, 64048-320, Brazil

    Flávia Ennes Dourado Ferro, Vanessa Batista de Sousa Lima, Nina Rosa Mello Soares & Dilina do Nascimento Marreiro

  2. Department of Science, Food and Experimental Nutrition, School of Pharmacy, University of São Paulo (USP), São Paulo, Brazil

    Kaluce Gonçalves de Sousa Almondes, Liliane Viana Pires & Silvia Maria Franciscato Cozzolino

Authors
  1. Flávia Ennes Dourado Ferro
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  2. Vanessa Batista de Sousa Lima
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  3. Nina Rosa Mello Soares
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  4. Kaluce Gonçalves de Sousa Almondes
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  5. Liliane Viana Pires
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  6. Silvia Maria Franciscato Cozzolino
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  7. Dilina do Nascimento Marreiro
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Correspondence to Dilina do Nascimento Marreiro.

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Ferro, F.E.D., de Sousa Lima, V.B., Soares, N.R.M. et al. Parameters of Metabolic Syndrome and Its Relationship with Zincemia and Activities of Superoxide Dismutase and Glutathione Peroxidase in Obese Women. Biol Trace Elem Res 143, 787–793 (2011). https://doi.org/10.1007/s12011-010-8940-6

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  • DOI: https://doi.org/10.1007/s12011-010-8940-6

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