Skip to main content
SpringerLink
Log in

The Suppressive Effects of Lanthanum on the Production of Inflammatory Mediators in Mice Challenged by LPS

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Lanthanide ions have been proven to have various biologic effects. Lanthanum with extremely active physical and chemical property was evidenced to possess antibacterial and immune adjustment effects. In the present study, the anti-inflammatory effects of lanthanum chloride (LaCl3) on lipopolysaccharide (LPS)-challenged mice were examined in vivo and in vitro. The results indicated that LaCl3 can greatly decrease the secretion of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β as well as TNF-α mRNA expression in the mice challenged with LPS. To clarify the mechanism involved, the effects of LaCl3 on the activation of nuclear factor (NF)-κB were examined both in liver and in peritoneal macrophages. The LPS-induced activation of NF-κB was significantly blocked by LaCl3. These findings demonstrate that the inhibition of the LPS-induced inflammatory media, such as TNF-α and IL-1β, by LaCl3, is due to the inhibition of NF-κ B activation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Pinsky MR (2007) Sepsis and multiple organ failure. Contrib Nephrol 156:47–63

    Article  PubMed  CAS  Google Scholar 

  2. Shigematsu T (2008) Lanthanum carbonate effectively controls serum phosphate without affecting serum calcium levels in patients undergoing hemodialysis. Ther Apher Dial 12:55–61

    Article  PubMed  CAS  Google Scholar 

  3. Hutchison AJ, Barnett ME, Krause R et al (2009) Lanthanum carbonate treatment, for up to 6 years, is not associated with adverse effects on the liver in patients with chronic kidney disease stage 5 receiving hemodialysis. Clin Nephrol 71:286–295

    PubMed  CAS  Google Scholar 

  4. Hadjiiski OG, Lesseva MI (1999) Comparison of four drugs for local treatment of burn wounds. Eur J Emerg Med 6:41–47

    PubMed  CAS  Google Scholar 

  5. de Gracia CG (2001) An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. Burns 27:67–74

    Article  PubMed  Google Scholar 

  6. Roland CR, Naziruddin B, Mohanakumar T et al (1996) Gadolinium chloride inhibits Kupffer cell nitric oxide synthase (iNOS) induction. J Leukoc Biol 60:487–492

    PubMed  CAS  Google Scholar 

  7. Fujii Y, Goldberg P, Hussain SN (1998) Contribution of macrophages to pulmonary nitric oxide production in septic shock. Am J Respir Crit Care Med 157:1645–1651

    PubMed  CAS  Google Scholar 

  8. Reed LJ, Munch H (1938) A simple method of estimating fifty percent endpoints. Am J Hyg 27:493–497

    Google Scholar 

  9. Yao YM, Xu CL, Yao FH et al (2006) The pattern of nuclear factor-kappaB activation in rats with endotoxin shock and its role in biopterin-mediated nitric oxide induction. Zhonghua Shao Shang Za Zhi 22:405–410

    PubMed  CAS  Google Scholar 

  10. Denlinger LC, Garis KA, Sommer JA et al (1998) Nuclear translocation of NF-kappaB in lipopolysaccharide-treated macrophages fails to correspond to endotoxicity: evidence suggesting a requirement for a gamma interferon-like signal. Infect Immun 66:1638–1647

    PubMed  CAS  Google Scholar 

  11. Zhang P, Martin M, Michalek S et al (2005) Role of mitogen-activated protein kinases and NF-κB in the regulation of proinflammatory and anti-inflammatory cytokines by porphyromonas gingivalis hemagglutinin B. Infect Immun 73:3990–3998

    Article  PubMed  CAS  Google Scholar 

  12. Cogswell JP, Godlevski MM, Wisely GB et al (1994) NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J Immunol 153:712–723

    PubMed  CAS  Google Scholar 

  13. Parmentier M, Hirani N, Rahman I et al (2000) Regulation of lipopolysaccharide-mediated interleukin-1beta release by N-acetylcysteine in THP-1 cells. Eur Respir J 16:933–939

    Article  PubMed  CAS  Google Scholar 

  14. Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2:725–734

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgement

The work was supported by the National Natural Science Foundation of China (30660182, 30960405), Natural Science Foundation of Jiangxi Province (2007GZY1132), Scientific Plan of Jiangxi Provincial Department of Public Health (20071041), and Program for Innovative Research Team of Nanchang University.

Author information

Authors and Affiliations

  1. Burns Institute, The First Affiliated Hospital, Nanchang University, Nanchang, China

    Fei Guo

  2. The Affiliated Hospital, Jiu Jiang University, Jiu Jiang, China

    Xiang Guo

  3. Institute of Urology, The First Affiliated Hospital, Nanchang University, Nanchang, China

    An Xie, Yuan Lei Lou & Yang Wang

Authors
  1. Fei Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiang Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. An Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yuan Lei Lou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yang Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Guo, F., Guo, X., Xie, A. et al. The Suppressive Effects of Lanthanum on the Production of Inflammatory Mediators in Mice Challenged by LPS. Biol Trace Elem Res 142, 693–703 (2011). https://doi.org/10.1007/s12011-010-8792-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-010-8792-0

Keywords

Search

Navigation