Abstract
The prevention of fatal cage-layer osteoporosis of gallium was studied in this paper. One-day-old hens were fed up to 68 weeks on a control diet and diets containing gallium. Plasma variables were measured during lay. End-of-lay trabecular and medullary bone volumes in the proximal tarsometatarsus and free thoracic vertebra were measured by histomorphometry. Medullary and trabecular bone volumes were increased significantly by supplementation with gallium. The experiment confirmed that dietary gallium supplementation was an effective way to enhance the egg production and reduce mortality percentage. The beneficial effects of gallium supplementation over the lifetime of the hens were attributable mainly to improved cage-layer osteoporosis.
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References
Riddell, C. (1989) Cage layer osteoporosis/fatigue—a review. In: 38th Western Poultry Disease Conference, Tempe, AZ. pp. 87–88.
Riddell, C. (1981) Skeletal deformities in poultry. IV. Cage layer osteoporosis/fatigue. Adv. Vet. Sci. Comp. Med. 25:277–310.
Cheng, T. K., and C. N. Coon. (1990a) Sensitivity of various bone parameters of laying hens to different daily calcium intakes. Poult. Sci. 69:2209–2213.
Cheng, T. K., and C. N. Coon. (1990b). Effect of calcium source, particle size, limestone solubility in vitro, and calcium intake level on layer bone status and performance. Poult. Sci. 69:2214–2219
Harms, R. H., S. M. Bootwalla, S. A. Woodward, and H. R. Wilson. (1990). Some observations on the influence of vitamin D metabolites when added to the diet of commercial laying hens. Poult. Sci. 69:426–432.
Elaroussi, M. A., L. R. Forte, S. L. Eber, and H. W. Biellier. (1994). Calcium homeostasis in the laying hen. Age and dietary calcium effects. Poult. Sci. 73:1581–1589.
Roland, D. A., Sr., and S. K. Rao. (1992) Nutritional and management factors related to osteopenia in laying hens, in: Whitehead, C.C. (Ed.) Bone Biology and Skeletal Disorders in Poultry, pp. 281– 295 (Carfax, Abingdon).
Sohail, S. S., and D. A. Roland, Sr. (2002). Influence of dietary phosphorus on performance of Hy-Line W36 hens. Poult. Sci. 81:75–83.
Warrell RP Jr. (1997) Gallium nitrate for the treatment of bone metastases. Cancer. 80:1680–5
Whitehead, C.C. & Wilson, S. (1992) Characteristics of osteopenia in hens, in: Whitehead, C.C. (Ed.) Bone Biology and Skeletal Disorders in Poultry, pp. 265–280
Kimmel, D.B. & Jee, W.S.S. (1983) Measurement of area, perimeter and distance: details of data collection in bone histomorphometry, in: Recker, R.R. (Ed.) Bone Histomorphometry, pp. 90–106 (Boca Raton, CRC Press).
Fleming RH, Whitehead CC, Alvey D, Gregory NG, Wilkins LJ (1994) Bone structure and breaking strength in laying hens housed in different husbandry systems. Br. Poult. Sci., 35: 651–662.
Patterson H.D., and Thompson R. (1971) Recovery of interblock information when block sizes are unequal. Biometrika, 58: 545–554.
Couch. R (1955) Cage layer fatigue. Feed Age, 5: 55–57.
Randall, C.J. & Duff, S.R.I. (1988) Avulsion of the patellar ligament in osteopenic laying fowl. Vet. Rec. 128:397–399.
Dudley HC, Maddox GE (1949) Deposition of radio gallium (72 Ga) in skeletal tissues. J Pharmacol Exp Ther 96:224–7.
Anghileri L (1971) Studies on the accumulation mechanisms of radioisotopes used in tumor diagnostic. Strahlentherapie 142:456–62.
Bockman R. (2003) The effects of gallium nitrate on bone resorption. Semin Oncol. 2003 A30:5–12.
McCoy, M. A., G. A. C. Reilly, and D. J. Kilpatrick (1996) Density and breaking strength of bones of mortalities among caged layers. Res. Vet. Sci. 60:185–186.
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Chen, X., Wang, C. Activity of Gallium on Prevention of Fatal Cage-Layer Osteoporosis. Biol Trace Elem Res 132, 129–135 (2009). https://doi.org/10.1007/s12011-009-8403-0
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DOI: https://doi.org/10.1007/s12011-009-8403-0