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Synthesis, Antibacterial, Antiurease, and Antioxidant Activities of Some New 1,2,4-Triazole Schiff Base and Amine Derivatives

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Abstract

The acylhydrazone compound named ethyl N′-furan-2-carbonylbenzohydrazonate was synthesized by the condensation of ethyl benzimidate hydrochloride with furan-2-carbohydrazide. The treatment of the acylhydrazone with hydrazine hydrate afforded 4-amino-3-furan-2-yl-5-phenyl-1,2,4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. The obtained products were identified by FT-IR, 1H-NMR, 13C-NMR. A series of compounds were evaluated for their antibacterial, antiurease, and antioxidant activities. The results showed that the synthesized new compounds had effective antiurease and antioxidant activities.

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Conflict of Interest

The authors declare no financial or other relationship that might lead to a conflict of interest.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, Giresun University, 28049, Giresun, Turkey

    Bahar Bilgin Sokmen & Yasemin Sagkal

  2. Vocational School of Health Sciences, 61080, Trabzon, Turkey

    Nurhan Gumrukcuoglu

  3. Department of Field Crops, Faculty of Agriculture and Natural Science, Düzce University, 81620, Düzce, Turkey

    Serpil Ugras

  4. Espiye Vocational School, Giresun University, 28600, Giresun, Turkey

    Huseyin Sahin

  5. Department of Chemistry, Faculty of Arts and Sciences, Düzce University, 81620, Düzce, Turkey

    Halil Ibrahim Ugras

Authors
  1. Bahar Bilgin Sokmen
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  2. Nurhan Gumrukcuoglu
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  3. Serpil Ugras
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  4. Huseyin Sahin
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  5. Yasemin Sagkal
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  6. Halil Ibrahim Ugras
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Correspondence to Bahar Bilgin Sokmen.

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Sokmen, B.B., Gumrukcuoglu, N., Ugras, S. et al. Synthesis, Antibacterial, Antiurease, and Antioxidant Activities of Some New 1,2,4-Triazole Schiff Base and Amine Derivatives. Appl Biochem Biotechnol 175, 705–714 (2015). https://doi.org/10.1007/s12010-014-1307-2

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  • DOI: https://doi.org/10.1007/s12010-014-1307-2

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