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Synthesis, Characterization and Biological Evaluation of Fe (III), Co (II), Ni(II), Cu(II), and Zn(II) Complexes with Tetradentate Schiff Base Ligand Derived from Protocatechualdehyde with 2-Aminophenol

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Abstract

Schiff base ligand (H3L) was prepared from the condensation reaction of protochatechualdehyde (3,4-dihydroxybenzaldhyde)with 2-amino phenol. From the direct reaction of the ligand (H3L) with Co(II), Ni(II) and Cu(II) chlorides, and Fe(III)and Zn(II)nitrates in 2 M/1 L molar ratio, the five new neutral complexes were prepared. The characterization of the newly formed compounds was done by 1H NMR, UV–Vis, and IR spectroscopy and elemental analysis. The in vitro antibacterial activity of the metal complexes was studied and compared with that of free ligand.

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Acknowledgment

We are grateful to the technical staff of the Microbiology Laboratory, Fermentation Biotechnology and Applied Microbiology Centre at Al-Azhar University for help in undertaking the antibacterial studies.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science (boys), Al-Azhar University, Nasr City, Cairo, Egypt

    A. M. Hassan, A. M. Nassar, Y. Z. Hussien & A. N. Elkmash

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  1. A. M. Hassan
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  2. A. M. Nassar
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  3. Y. Z. Hussien
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  4. A. N. Elkmash
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Correspondence to A. M. Nassar.

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Hassan, A.M., Nassar, A.M., Hussien, Y.Z. et al. Synthesis, Characterization and Biological Evaluation of Fe (III), Co (II), Ni(II), Cu(II), and Zn(II) Complexes with Tetradentate Schiff Base Ligand Derived from Protocatechualdehyde with 2-Aminophenol. Appl Biochem Biotechnol 167, 581–594 (2012). https://doi.org/10.1007/s12010-012-9709-5

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