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Potential of Crocus sativus (saffron) and its Constituent, Crocin, as Hypolipidemic and Antioxidant in Rats

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Abstract

The aim of the present study was to evaluate the hypolipidemic and antioxidant potential of saffron and its active constituent, crocin, in hyperlipidemic rats. The animals fed either with normal fat diet or high fat diet were administered orally saffron (25, 50, and 100 mg/kg) or crocin (4.84, 9.69, and 19.38 mg/kg) in their respective groups for five consecutive days. Biochemical estimations of triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), alkaline phosphatase (ALP), aspartate transaminase (AST), alanine aminotransferase (ALT), malondialdehyde (MDA), glutathione peroxidase enzyme activity (GSHPx), total glutathione (GSH), and oxidized glutathione (GSSG) in serum and superoxide dismutase (SOD), catalase (CAT), thiobarbituric acid reactive species (TBARS), ferric reducing/antioxidant power (FRAP), and total sulfhydryl (SH) groups in liver tissue homogenate were carried out. Both saffron and crocin were effective in decreasing the elevated levels of TG, TC, ALP, AST, ALT, MDA, GSHPx, GSH, and GSSG in serum and increasing SOD, CAT, FRAP, and SH values in liver tissue with reduction in TBARS. The saffron was found to be superior to crocin indicating the involvement of other potential constituents of saffron apart from crocin for its synergistic behavior of quenching the free radicals and ameliorating the damages of hyperlipidemia.

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Authors and Affiliations

  1. Department of Pharmacology, Krupanidhi College of Pharmacy, # 5, Sarjapur road, Koramangala, Bangalore, 560 034, India

    Syed Mohammed Basheeruddin Asdaq

  2. Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, 560 027, India

    Mohammed Naseeruddin Inamdar

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  1. Syed Mohammed Basheeruddin Asdaq
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  2. Mohammed Naseeruddin Inamdar
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Correspondence to Syed Mohammed Basheeruddin Asdaq.

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Asdaq, S.M.B., Inamdar, M.N. Potential of Crocus sativus (saffron) and its Constituent, Crocin, as Hypolipidemic and Antioxidant in Rats. Appl Biochem Biotechnol 162, 358–372 (2010). https://doi.org/10.1007/s12010-009-8740-7

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  • DOI: https://doi.org/10.1007/s12010-009-8740-7

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